A5023656796- Neurobiology of Language and Bilingualism
- Text Readability and Simplification
- Cardiac and Coronary Surgery Techniques
- Cardiac, Anesthesia and Surgical Outcomes
- Intracranial Aneurysms: Treatment and Complications
- Parkinson's Disease Mechanisms and Treatments
- Aortic Disease and Treatment Approaches
- Advanced Neuroimaging Techniques and Applications
- Intracerebral and Subarachnoid Hemorrhage Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Hemodynamic Monitoring and Therapy
- Neurological disorders and treatments
- Cerebrovascular and Carotid Artery Diseases
- Neurosurgical Procedures and Complications
- Non-Invasive Vital Sign Monitoring
- Bone fractures and treatments
- Intensive Care Unit Cognitive Disorders
- Cardiac Arrest and Resuscitation
- Cardiovascular Health and Disease Prevention
- Reconstructive Surgery and Microvascular Techniques
- Tuberous Sclerosis Complex Research
- Interpreting and Communication in Healthcare
- Obesity, Physical Activity, Diet
- Protease and Inhibitor Mechanisms
- Linguistics and Cultural Studies
St George's, University of London
2018-2024
University Hospitals of Leicester NHS Trust
2015-2023
University of London
2019-2021
Universidad de Londres
2021
University of Leicester
2015-2020
Glenfield Hospital
2015-2020
St George's Hospital
2019
NIHR Leicester Biomedical Research Centre
2018
Leicester Royal Infirmary
2017
NIHR Leicester Cardiovascular Biomedical Research Unit
2015-2016
Background Thousands of air bubbles enter the cerebral circulation during cardiac surgery, but whether high numbers explain post-operative cognitive decline is currently controversial. This study estimates size distribution and volume entering arteries intra-operatively based on analysis transcranial Doppler ultrasound data. Methods Transcranial recordings from ten patients undergoing heart surgery were analysed for presence embolic signals. The backscattered intensity each signal was...
To evaluate a series of patients treated electively with carotid endarterectomy (CEA), transfemoral artery stenting distal filter protection (CASdp), and transcervical dynamic flow reversal (CASfr) monitored continuously transcranial Doppler (TCD) during the procedure to detect intraoperative embolization rates.Thirty-four (mean age 67.6 years; 24 men) significant stenosis underwent successful TCD monitoring revascularization (10 CEA, 8 CASdp, 16 CASfr). Ipsilateral microembolic signals were...
Normative values of physiological parameters hold significance in modern day clinical decision-making. Lack such normative has been a major hurdle the translation research into practice. A large database containing uniform recordings was constructed to allow more robust estimates ranges and also assess influence age sex.
Background and Purpose— Cerebral microbleeds (CMBs) have been observed using magnetic resonance imaging in patients with cardiovascular risk factors, cognitive deterioration, small vessel disease, dementia. They are a well-known consequence of cerebral amyloid angiopathy, chronic hypertension, diffuse axonal injury, among other causes. However, the frequency location new CMBs postadult cardiac surgery, association cognition perioperative yet to be studied. Methods— Pre- postsurgery...
There are few available methods for qualitatively evaluating patients with primary progressive aphasia. Commonly adopted approaches time-consuming, of limited accuracy or designed to assess different patient populations. This paper introduces a new clinical test-the Mini Linguistic State Examination-which was uniquely enable clinician and subclassify both classical mixed presentations The adoption novel assessment method (error classification) greatly amplifies the information that can be...
Off-pump coronary artery bypass (OPCAB) surgery is being increasingly reported to show better outcomes compared conventional on grafting. We examined the effect of OPCAB in-hospital mortality and morbidity, while adjusting for patient disease characteristics, in four institutions North West England.Between April 1997 March 2001, 10,941 consecutive patients underwent isolated at these institutions. Of these, 7.7% were performed off-pump. used logistic regression examine morbidity after...
Background and Purpose— Brain injury after cardiac surgery is a serious concern for patients their families. The purpose of this study was to use 3-T fluid attenuated inversion recovery MRI characterize new preexisting cerebral ischemic lesions in undergoing test whether the accumulation adversely affects cognition. Methods— Digital comparison before images performed 77 patients. burden versus quantified compared with results baseline postoperative neuropsychological testing. Results— After...
ObjectivesThis study draws on advances in Doppler ultrasound bubble sizing to investigate whether high volumes of macro-bubbles entering the brain during cardiac surgery increase risk new cerebral microbleeds (CMBs), ischemic MR lesions, or post-operative cognitive decline (POCD).MethodsTranscranial (TCD) recordings were analysed estimate numbers emboli and macrobubbles (>100 μm) surgery. Logistic regression was used explore hypothesis that characteristics affect incidence injuries...
Background: Progressive supranuclear palsy (PSP) and corticobasal syndrome (CBS) affect speech language as well motor functions. Clinical neuropathological data indicate a close relationship between these two disorders the non-fluent variant of primary progressive aphasia (nfvPPA). We use recently developed Mini Linguistic State Examination tool (MLSE) to study in patients with PSP, CBS, nfvPPA, combination structural magnetic resonance imaging (MRI). Methods: Fifty-one (PSP N = 13, CBS 19,...
Clinical variants of primary progressive aphasia (PPA) are diagnosed based on characteristic patterns language deficits, supported by corresponding neural changes brain imaging. However, there is (i) considerable phenotypic variability within and between each diagnostic category with partially overlapping profiles performance (ii) accompanying non-linguistic cognitive impairments that may be independent magnitude disease severity. The neurobiological basis this cognitive-linguistic...
The detection of new subtle brain pathology on MR imaging is a time-consuming and error-prone task for the radiologist. This article introduces evaluates an image-registration subtraction method highlighting small changes in with view to minimizing risk missed reducing fatigue.We present fully automated algorithm between multiple serially acquired images novel approach registration bias field correction. was evaluated lesions 77 patients undergoing cardiac surgery, by using pairs...
Background: Primary progressive aphasia (PPA) is a neurodegenerative syndrome with three main clinical variants: non-fluent, semantic, and logopenic. Clinical diagnosis accurate classification are challenging often time-consuming. The Mini-Linguistic State Examination (MLSE) has been recently developed as short language test to specifically assess in disorders. Objective: Our aim was adapt validate the Spanish version of MLSE for PPA diagnosis. Methods: Cross-sectional study involving 70...
Abstract Background This paper introduces a new clinical test, the Mini Linguistic State Examination (MLSE), as short assessment for screening and classification of different manifestations primary progressive aphasia (PPA). Differentiation monitoring PPA variants are vital management, planning development treatments. The MLSE is designed to improve uniformity testing, recruitment trials, consistency research results. It brief but effective test which can be adapted world’s major languages....
Connected speech samples elicited by a picture description task are widely used in the assessment of aphasias, but it is not clear what their interpretation should focus on. Although such easy to collect, analyses them tend be time-consuming, inconsistently conducted and impractical for non-specialist settings. Here, we analysed connected from patients with three variants primary progressive aphasia (semantic, svPPA
Abstract Background Language assessment is critical in the diagnosis of patients with neurodegenerative diseases, particular those presenting progressive speech and language impairment such as primary aphasias (PPA). Current diagnostic criteria identify three main variants PPA based on clinical neuroimaging features: semantic variant ‐ characterised by dramatically reduced ability to understand meaning words objects; nonfluent – featuring problems grammatical phonetic aspects production;...
Background: There are few available methods for qualitatively evaluating patients with primary progressive aphasia (PPA). Commonly adopted approaches time-consuming, of limited accuracy, or designed to assess different patient populations. This paper introduces a new clinical test - the Mini Linguistic State Examination (MLSE) which was uniquely enable clinician and subclassify both classical mixed presentations PPA. The adoption novel assessment method (error classification) greatly...
Language assessment is critical in the diagnosis of patients with neurodegenerative diseases, particular those presenting progressive speech and language impairment such as primary aphasias (PPA). Current diagnostic criteria identify three main variants PPA based on clinical neuroimaging features: semantic variant - characterised by dramatically reduced ability to understand meaning words objects; nonfluent – featuring problems grammatical prosodic aspects production; logopenic a striking...
Abstract Background Primary progressive aphasia (PPA) is a clinical syndrome of neurodegenerative origin with three main variants (nonfluent, semantic, and logopenic). Clinical diagnosis accurate classification into the challenging often time‐consuming. The Mini‐Linguistic State Examination (MLSE) has been recently developed as short language test specifically designed for assessment in disorders. Our aim was to adapt validate Spanish version MLSE PPA diagnosis. Method Cross‐sectional study...