A5054623144- ZnO doping and properties
- Quantum and electron transport phenomena
- Magnetic and transport properties of perovskites and related materials
- Magnetic properties of thin films
- Physics of Superconductivity and Magnetism
- Semiconductor Quantum Structures and Devices
- Natural Language Processing Techniques
- Chalcogenide Semiconductor Thin Films
- Heusler alloys: electronic and magnetic properties
- Advancements in Semiconductor Devices and Circuit Design
- Semantic Web and Ontologies
- Advanced Chemical Physics Studies
- Pediatric Hepatobiliary Diseases and Treatments
- Electronic and Structural Properties of Oxides
- Semiconductor materials and interfaces
- Advanced Semiconductor Detectors and Materials
- Liver physiology and pathology
- Molecular Junctions and Nanostructures
- Wnt/β-catenin signaling in development and cancer
- Surface and Thin Film Phenomena
- Phase-change materials and chalcogenides
- Congenital heart defects research
- Rare-earth and actinide compounds
- Ga2O3 and related materials
- Semiconductor materials and devices
Charles University
1975-2024
Karolinska Institutet
2017-2024
Czech Academy of Sciences, Institute of Biophysics
2023
Masaryk University
2010-2023
VUKV (Czechia)
2023
Ocní klinika
2022
University of Hradec Králové
2022
Czech Academy of Sciences
1994-2018
Czech Academy of Sciences, Institute of Molecular Genetics
2013-2018
Czech Academy of Sciences, Institute of Physics
2005-2017
The body of research on (III,Mn)V diluted magnetic semiconductors initiated during the 1990's has concentrated three major fronts: i) microscopic origins and fundamental physics ferromagnetism that occurs in these systems, ii) materials science growth defects iii) development spintronic devices with new functionalities. This article reviews current status field, concentrating first two, more mature directions. From point view, (Ga,Mn)As several other DMSs are now regarded as textbook...
We predict that a lateral electrical current in antiferromagnets can induce non-equilibrium N\'eel order fields, i.e. fields whose sign alternates between the spin sublattices, which trigger ultra-fast spin-axis reorientation. Based on microscopic transport theory calculations we identify staggered current-induced analogous to intra-band and intrinsic inter-band spin-orbit previously reported ferromagnets with broken inversion-symmetry crystal. To illustrate their rich physics utility,...
We report on a comprehensive combined experimental and theoretical study of Curie temperature trends in (Ga,Mn)As ferromagnetic semiconductors. Broad agreement between expectations measured data allows us to conclude that ${T}_{c}$ high-quality metallic samples increases linearly with the number uncompensated local moments ${\mathrm{Mn}}_{\mathrm{Ga}}$ acceptors, no sign saturation. Room ferromagnetism is expected for 10% concentration these moments. Our magnetotransport magnetization are...
Abstract Reconstruction of heterogeneity through single cell transcriptional profiling has greatly advanced our understanding the spatial liver transcriptome in recent years. However, global differences across lobular units remain elusive physical space. Here, we apply Spatial Transcriptomics to perform transcriptomic analysis sectioned tissue. We confirm that this complex tissue is predominantly determined by zonation. By introducing novel computational approaches, enable gradient...
Receptor tyrosine kinase signaling cooperates with WNT/β-catenin in regulating many biological processes, but the mechanisms of their interaction remain poorly defined. We describe a potent activation by FGFR2, FGFR3, EGFR and TRKA kinases, which is independent PI3K/AKT pathway. Instead, this phenotype depends on ERK MAP kinase-mediated phosphorylation WNT co-receptor LRP6 at Ser1490 Thr1572 during its Golgi network-based maturation process. This dramatically increases cellular response to...
We discuss the character of states near Fermi level in Mn-doped GaAs, as revealed by a survey dc transport and optical studies over wide range Mn concentrations. A thermally activated valence-band contribution to transport, midinfrared peak at energy $\ensuremath{\hbar}\ensuremath{\omega}\ensuremath{\approx}200\phantom{\rule{0.3em}{0ex}}\mathrm{meV}$ ac conductivity, hot photoluminescence spectra indicate presence an impurity band low-doped ($⪡1%$ Mn) insulating GaAs:Mn materials. Consistent...
One of the main obstacles that prevents practical applications antiferromagnets is difficulty manipulating magnetic order parameter. Recently, following theoretical prediction [J. \ifmmode \check{Z}\else \v{Z}\fi{}elezn\'y et al., Phys. Rev. Lett. 113, 157201 (2014)], electrical switching moments in an antiferromagnet was demonstrated [P. Wadley Science 351, 587 (2016)]. The due to so-called spin-orbit torque, which has been extensively studied ferromagnets. In this phenomena a...
TALE-class homeodomain transcription factors Meis and Pbx play important roles in formation of the embryonic brain, eye, heart, cartilage or hematopoiesis. Loss-of-function studies Pbx1, 2 3 Meis1 documented specific functions embryogenesis, however, functional Meis2 mouse are still missing. We have generated a conditional allele mice shown that systemic inactivation gene results lethality by day 14 is accompanied with hemorrhaging. show neural crest cells express Meis2-defficient embryos...
Alagille syndrome is a genetic disorder characterized by cholestasis, ocular abnormalities, characteristic facial features, heart defects, and vertebral malformations. Most cases are associated with mutations in JAGGED1 (JAG1), which encodes Notch ligand, although it not clear how these contribute to disease development. We aimed develop mouse model of elucidate mechanisms.Mice missense mutation (H268Q) Jag1 (Jag1+/Ndr mice) were outbred C3H/C57bl6 background generate for (Jag1Ndr/Ndr mice)....
Notch signaling controls multiple aspects of embryonic development and adult homeostasis. Alagille syndrome is usually caused by a single mutation in the jagged canonical ligand 1 (JAG1), manifests with liver disease cardiovascular symptoms that are direct consequence JAG1 haploinsufficiency. Recent insights into Jag1/Notch-controlled developmental homeostatic processes explain how pathology develops hepatic systems and, together recent elucidation mechanisms modulating regeneration, provide...
LDL-related protein 6 (LRP6) is a coreceptor of WNTs and key regulator the WNT/-catenin pathway.Upon activation, LRP6 phosphorylated within its intracellular PPPS/TP motifs.These motifs are required to recruit axin inhibit glycogen synthase kinase 3 (GSK3), two basic components -catenin destruction complex.On basis kinome-wide small interfering RNA (siRNA) screen confirmative biochemical analysis, we show that several proline-directed mitogen-activated kinases (MAPKs), such as p38, ERK1/2,...
Our x-ray photoemission, magnetization, and transport studies on surface-etched annealed (Ga,Mn)As epilayers elucidate the key role of surface oxide in controlling outdiffusion self-compensating interstitial Mn impurities. We achieved a dramatic reduction annealing times necessary to optimize after growth synthesized films with Curie temperature reaching 180 K. A $p\text{\ensuremath{-}}n$ junction transistor is introduced, allowing for large hole depletion thin at few volts. The etching...
By using spin-polarized full potential linearized augmented plane wave method we obtained the electronic structure of (Ga,Mn)As crystals with Mn in substitutional, interstitial, and both positions. It is shown that interstitial acts as a double donor compensates holes created by two atoms substitutional This explains why number ${\mathrm{Ga}}_{1\ensuremath{-}x}{\mathrm{Mn}}_{x}\mathrm{As}$ usually much smaller than x. The effective doping efficiency simply related to proportion does not...
We propose to replace Ga in (Ga,Mn)As with Li and Zn as a route high Curie temperature, carrier mediated ferromagnetism dilute moment n-type semiconductor. Superior material characteristics, rendering Li(Zn,Mn)As realistic candidate for such system, include solubility of the isovalent substitutional Mn impurity concentration controlled independently doping by adjusting Li-(Zn,Mn) stoichiometry. Our predictions are anchored ab initio calculations comparisons familiar directly related...
Dishevelled (Dvl) is a multifunctional effector of different Wnt cascades. Both canonical Wnt3a and noncanonical Wnt5a stimulate casein-kinase-1 (CK1) -mediated phosphorylation Dvl, visualized as electrophoretic mobility shift [phosphorylated shifted Dvl (ps-Dvl)]. However, the role this remains obscure. Here we report functional interaction ps-Dvl with receptor tyrosine kinase Ror2, which an alternative able to inhibit signaling. We demonstrate between Ror2 at cell membrane after or...
Our ab initio theory calculations predict a semiconducting band structure of I-Mn-V compounds. We demonstrate on LiMnAs that high-quality materials with group-I alkali metals in the crystal can be grown by molecular beam epitaxy. Optical measurements epilayers are consistent theoretical electronic structure. also reproduce earlier reports high antiferromagnetic ordering temperature and large, spin-orbit-coupling-induced magnetic anisotropy effects. propose strategy for employing...
Generation of neurons in the embryonic neocortex is a balanced process proliferation and differentiation neuronal progenitor cells. Canonical Wnt signalling crucial for expansion radial glial cells ventricular zone intermediate progenitors subventricular zone. We detected abundant expression two transcrtiption factors mediating canonical signalling, Tcf7L1 Tcf7L2, neocortex. Conditional knock-out analysis showed that but not Tcf7L1, principal mediator important maintenance cell identity In...
We use the density-functional calculations to investigate compositional dependence of lattice constant (Ga,Mn)As containing various native defects. The perfect mixed crystals does not depend much on concentration Mn. parameter increases if some Mn atoms occupy interstitial positions. same happens As antisite defects are present. A quantitative agreement with observed is obtained for materials close a complete compensation due these two donors. increase correlated degree compensation: low...
We report on a systematic study of optical properties (Ga,Mn)As epilayers spanning the wide range accessible Mn(Ga) dopings. The material synthesis was optimized for each nominal Mn doping in order to obtain films which are as close possible uniform uncompensated mixed crystals. observe broad maximum mid-infrared absorption spectra whose position exhibits prevailing blueshift increasing doping. In visible range, peak magnetic circular dichroism also shifts with results consistent description...