Irene Mwangi
A5069120568- Hepatitis B Virus Studies
- Vaccine Coverage and Hesitancy
- Hepatitis Viruses Studies and Epidemiology
- Hematopoietic Stem Cell Transplantation
- Viral Infections and Vectors
- Global Health and Epidemiology
- HIV/AIDS Research and Interventions
- Viral Infections and Outbreaks Research
- HIV Research and Treatment
- Hepatitis C virus research
- Parasite Biology and Host Interactions
- Herpesvirus Infections and Treatments
- Vector-Borne Animal Diseases
- vaccines and immunoinformatics approaches
- Mosquito-borne diseases and control
- Monoclonal and Polyclonal Antibodies Research
- Virology and Viral Diseases
- Immunodeficiency and Autoimmune Disorders
- Parasites and Host Interactions
- Animal Virus Infections Studies
University of Nairobi
2021-2025
Jomo Kenyatta University of Agriculture and Technology
2023
Kenya AIDS Vaccine Initiative
2014-2021
University of Manitoba
2018
Even within the context of antiretroviral treatment and prevention, an HIV-1 vaccine remains best strategy for ending HIV/AIDS epidemic. A is particularly needed in sub-Saharan Africa, where greatly affects people's lives economy. Here, we aimed to assess safety immunogenicity candidate T-cell vaccines African populations. HIV-CORE 006 was a double-blind, randomised, placebo-controlled phase 1 trial conducted across four clinical research centres Uganda, Kenya, Zambia. Eligible participants...
Crimean Congo Hemorrhagic Fever (CCHF) is an emerging tick-borne zoonotic viral disease with the potential of causing public health emergencies. However, less known about role wildlife and livestock in spreading virus. Therefore, we aimed to assess how interactions between African buffalo (Syncerus caffer) cattle may influence seroprevalence CCHF across livestock-wildlife management systems Kenya. The study included archived sera samples from only habitats (Lake Nakuru National Park Solio...
Background: The world needs an effective HIV-1/AIDS vaccine. Even in the broader context of antiretroviral treatment and prevention, a vaccine remains best solution likely key component any package truly ending AIDS epidemic. Vaccine is particularly needed most affected regions like sub-Saharan Africa, where HIV-1 significantly impacts people's lives economy.Methods: CD8+ killer T cells impose selective pressure on their protective potential should be utilized for vaccination. Our program...
Healthcare workers (HCWs) have a significant occupational risk of hepatitis B virus (HBV) infection. Vaccination remains the most effective measure recommended to avert risk. However, there’s limited information on vaccine uptake rates and seroprotection status HCWs, especially in sub-Saharan Africa. This study aimed assess vaccination also HCWs three selected public hospitals Kenya. was cross-sectional carried out among at Kenyatta National Hospital (KNH), Naivasha Mbagathi County...
People living with HIV constitute an important part of the population in regions at risk Ebola virus disease outbreaks. The two-dose Ad26.ZEBOV, MVA-BN-Filo vaccine regimen induces strong immune responses HIV-positive (HIV+) adults but durability this response is unknown. It also unclear whether can establish memory to enable anamnestic upon re-exposure antigen.
Attenuated varicella zoster virus (VZV) is a promising vector for recombinant vaccines. Because human immunodeficiencyvirus (HIV) vaccines are believed to require mucosal immunogenicity, we characterized VZV-specific humoral immunity following VZVOka vaccination.Adult Kenyan VZV-seropositive women (n = 44) received single dose of the live vaccine. The anamnestic responses were followed longitudinally in both plasma and secretions using an in-house glycoprotein enzyme-linked immunosorbent...
Urinary cytokines are gaining traction as tools for assessing morbidity in infectious and non-infectious inflammatory diseases of the urogenital tract. However, little is known about potential these due to S. haematobium infections. Factors that may influence urinary cytokine levels markers also remain unknown. Therefore objective present study was assess how interleukins (IL-) 6 10 associated with gender, age, infections, haematuria tract pathology and; 2) effects urine storage temperatures...