A5073069003- Probiotics and Fermented Foods
- Cardiovascular Function and Risk Factors
- Gut microbiota and health
- Heart Failure Treatment and Management
- Cardiac pacing and defibrillation studies
- Anaerobic Digestion and Biogas Production
- Transplantation: Methods and Outcomes
- HIV-related health complications and treatments
- Cardiac Imaging and Diagnostics
- Congenital Heart Disease Studies
- Biofuel production and bioconversion
- Cardiac electrophysiology and arrhythmias
- Genomics and Phylogenetic Studies
- HIV/AIDS drug development and treatment
- Pulmonary Hypertension Research and Treatments
- Meat and Animal Product Quality
- Cardiac Arrhythmias and Treatments
- HIV/AIDS Research and Interventions
- Peripheral Neuropathies and Disorders
- Mechanical Circulatory Support Devices
- Infectious Encephalopathies and Encephalitis
- Microbial Metabolites in Food Biotechnology
- Protein Hydrolysis and Bioactive Peptides
- Cytomegalovirus and herpesvirus research
- Cellular transport and secretion
Università Cattolica del Sacro Cuore
2016-2025
Istituto Mediterraneo per i Trapianti e Terapie ad Alta Specializzazione
2024
Istituti di Ricovero e Cura a Carattere Scientifico
2003-2024
Instituto Chico Mendes de Conservação da Biodiversidade
2022
Zero to Three
2022
University of Catania
2020-2021
Ospedale Papa Giovanni XXIII
2013-2020
Institut Supérieur d'Électronique de Paris
2020
University of Cagliari
2020
Technical University of Denmark
2018
The study aimed at evaluating the prevalence of interventricular and intraventricular contractile dyssynchrony in heart failure patients with either normal or prolonged QRS duration.Echocardiography tissue Doppler imaging (TDI) were performed 158 consecutive advanced left ventricular dysfunction (LVEF<35%); 61 had a duration (Group 1), 21 bundle branch block between 120 150 ms 2) 76 #10878;150 3). Interventricular (defined by presence an mechanical delay greater than 40 ms) was found 12.5%,...
To compare the use of co-medication, potential drug–drug interactions (PDDIs) and effect on antiretroviral therapy (ART) tolerability efficacy in HIV-infected individuals according to age, ≥50 years or <50 years. All ART-treated participants were prospectively included once during a follow-up visit Swiss HIV Cohort Study. Information any current medication was obtained by participant self-report medical prescription history. The complete treatment subsequently screened for PDDIs using...
Background Blood lipid abnormalities in patients on highly active antiretroviral therapy (HAART) have been associated with exposure to protease inhibitors (PIs), particularly ritonavir. First a non-nucleoside reverse transcriptase inhibitor (NNRTI) leads relatively favourable profiles. We report medium-term profiles (up 5 years) for antiretroviral-naive starting NNRTI- and PI-based HAART the Swiss HIV Cohort Study. Methods Since April 2000, blood samples taken at visits scheduled every 6...
Lactobacillus helveticus belongs to the large group of lactic acid bacteria (LAB), which are major players in fermentation a wide range foods. LAB also present human gut, has often been exploited as reservoir potential novel probiotic strains, but several parameters need be assessed before establishing their safety and use for consumption. In study, six L. strains isolated from natural whey cultures were analyzed phenotype genotype exopolysaccharide (EPS) production, low pH bile salt...
The present research is the first comprehensive study regarding thermophilic anaerobic degradation of cheese wastewater, which combines evaluation different reactor configurations (i.e. single and two-stage continuous stirred tank reactors) on process efficiency in-depth characterization microbial community structure using genome-centric metagenomics. Both showed acidification problems under tested organic loading rates (OLRs) 3.6 2.4 g COD/L-reactor day hydraulic retention time (HRT) 15...
The expansion of renewable energy produced by windmills and photovoltaic panels has generated a considerable electricity surplus, which can be utilized in water electrolysis systems for hydrogen production. resulting then funneled to anaerobic digesters biogas upgrading (biomethanation) purposes (power-to-methane) or produce high value-added compounds such as short-chain fatty acids (power-to-chemicals). Genome-centric metagenomics metatranscriptomic analyses were performed better understand...
Sourdough fermentation of bakery products is a well-established and widespread technique to confer an added value the resulting food. In recent decades, gluten-free raw materials have gained more attention due diffusion food disorders such as coeliac disease, but, at same time, they present difficult manipulation scarce technological properties because absence gluten. For this reason, work was aimed selecting starter cultures for sourdough application that are isolated from sorghum flour....
Wasted bread (WB) has been studied as an alternative ingredient for increasing the sustainable footprint in beer production chain. There are gaps literature on impact of WB manufacturing. Thus, objective was to evaluate addition a replacement wheat flakes craft beer. Three formulations with different concentrations were produced and monitored glucose maltose mash; analyzed ethanol, glycerol, acetic acid, lactic pH, acidity, turbidity, color, volatile compounds. Sensory analysis performed by...
The objective of this study was to investigate the effect different animal feedings operated in two distinct PDO (protected designation origin) cheese production areas (Parmigiano Reggiano and Grana Padano) on microbiome six full-scale biogas plants, by means Illumina sequencing qPCR techniques. effects feedstock (cattle slurry manure, energy crops, agro-industrial by-products), temperature (mesophilic/thermophilic), operating time were also examined, as relationships between predominant...
Heart transplantation (HTx) in patients with complex congenital heart disease (CHD) is a challenge because of structural anomalies and multiple previous procedures. We analysed our results adult paediatric to evaluate outcome assess risk factors affecting mortality.Between 1985 2011, among 839 who underwent HTx, 85 received for end-stage CHD. Patients were divided into four age subgroups: <1 year (8 patients, Group I), 1-10 years (20 II), 11-18 (24 III) >18 (33 IV) two time periods:...
Beneficial effects of probiotics on gut microbiota homeostasis and inflammatory immune responses suggested the investigation their potential clinical efficacy in experimental models autoimmune diseases. Indeed, administration two bifidobacteria lactobacilli probiotic strains prevented disease manifestations Lewis rat model Myasthenia Gravis (EAMG). Here, we demonstrate therapeutic vital (i.e. from EAMG onset). The mechanisms involved immunomodulation were investigated with ex vivo vitro...
Lactobacillus casei/paracasei group of species contains strains adapted to a wide range environments, from dairy products intestinal tract animals and fermented vegetables. Understanding the gene acquisitions losses that induced such different adaptations, implies comparison between complete genomes, since evolutionary differences spread on whole sequence. This study compared 12 genomes L. dairy-niche isolates 7 isolated other habitats (i.e. corn silage, human intestine, sauerkraut, beef,...
In addition to energy recovery, the anaerobic digestion of agro-industrial byproducts can also produce different high-value-added compounds. Two-stage and single-stage reactors were compared for microbial communities’ selection long-chain fatty acid (LCFA) accumulation investigate which genera are most linked production these The communities present in two reactors’ configuration steady state characterised by 16S rRNA amplicon sequencing, while LCFAs extracted quantified from digestate...
Abstract Aims The identification of subjects at higher risk for incident heart failure (HF) with preserved ejection fraction (EF) suitable more intensive preventive programmes remains challenging. We applied phenomapping to the DAVID‐Berg population, comprising preclinical HF, aiming refine HF stratification. Methods study prospectively enrolled 596 asymptomatic outpatients EF > 40% hypertension, diabetes mellitus or known cardiovascular disease. In this cohort, we performed an...
Cyclin-dependent kinase (CDK)4/6-inhibitors with endocrine therapy represent the standard of treatment hormone receptor-positive(HR+)/human epidermal growth factor receptor 2 (HER2)-negative metastatic breast cancer (MBC). Gut microbiota seems to predict response in several tumour types, being directly implied chemotherapy resistance and development adverse effects. No evidence is available on gut impact efficacy HR+ treatment.We assessed potential association among faecal therapeutic...
Abstract Background Natriuretic peptides and diastolic dysfunction have prognostic value in asymptomatic subjects at risk for heart failure. Their integration might further refine the stratification process this setting. Aim of paper was to explore possibility predict failure death combining natriuretic an population Methods Among 4047 aged ≥55/≤80 years followed by 10 general practitioners Italy, DAVID-Berg study prospectively enrolled 623 outpatients increased Baseline evaluation included...
A novel Gram-stain-positive, strictly aerobic, short rod-shaped bacterium, designated 2C T , was isolated from freshly packaged microfiltered milk. This strain able to grow within the NaCl concentration range of 0–5 % (w/v), temperature 8–37 °C (optimally at 30 °C) and pH 6.0–10.0. Phylogenetic analysis based on 16S rRNA gene sequences revealed that closely related species genus Microbacterium with highest sequence similarity (99.2 %) lacticum DSM 20427 as well flavum 18909 (=YM18-098 ). The...