A5100720415- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Virus-based gene therapy research
- Radiomics and Machine Learning in Medical Imaging
- Ferroptosis and cancer prognosis
- Cancer-related Molecular Pathways
- Cancer-related cognitive impairment studies
- Bioinformatics and Genomic Networks
- Histone Deacetylase Inhibitors Research
- Cancer-related gene regulation
- Viral gastroenteritis research and epidemiology
- Fibroblast Growth Factor Research
- Brain Metastases and Treatment
- Viral Infectious Diseases and Gene Expression in Insects
- Heme Oxygenase-1 and Carbon Monoxide
- Glioma Diagnosis and Treatment
- Cancer survivorship and care
- PI3K/AKT/mTOR signaling in cancer
- Medical Imaging Techniques and Applications
- CAR-T cell therapy research
- MRI in cancer diagnosis
- Cytomegalovirus and herpesvirus research
- Animal Virus Infections Studies
- Kruppel-like factors research
- Cancer Genomics and Diagnostics
Sichuan University
2011-2022
West China Hospital of Sichuan University
2022
Wuxi Fourth People's Hospital
2018-2021
Jiangnan University
2018-2021
Binzhou University
2020
Binzhou Medical University
2020
The Fourth People's Hospital
2019
Wuxi No.2 People's Hospital
2019
Breast Center
2010
Background Aberrant DNA methylation patterns might be used as a biomarker for diagnosis and management of cancer patients. Methods Findings To achieve gene panel developing breast blood-based test we quantitatively assessed the proportion 248 CpG sites per sample (total 31,248 in all analyzed samples) on 10 candidate genes (APC, BIN1, BMP6, BRCA1, CST6, ESR-b, GSTP1, P16, P21 TIMP3). The number 126 samples consisting two different cohorts was (first cohort: plasma from patients normal...
BACKGROUND:Chemotherapy can cause adverse effects such as chemotherapy-related cognitive impairment (CRCI). In this prospective study, the efficacy of traditional Chinese medicine acupuncture therapy in relieving CRCI and its impact on serum brain-derived neurotrophic factor (BDNF) are evaluated. MATERIAL AND METHODS:Eighty patients were randomly divided into a treatment group control with 40 each group. The was treated at following points: Baihui (DU20), Sishencong (EX-HN1), Shenting...
Background: Ovarian carcinoma is a common malignant tumor of the female reproductive organs with an incidence rate second only to cervical and endometrial cancers. In past 10 years, anticancer therapy has focused on Niclosamide, anthelmintic teniacide that commonly used against tapeworms been approved for use in humans nearly 50 years. Importantly, Niclosamide confirmed target Wnt/β-catenin, mTOR, STAT3, NF-κB, Notch pathways widely investigated multiple cancer types. However, potential...
The present study investigated promoter hypermethylation of TP53 regulatory pathways providing a potential link between epigenetic changes and mitochondrial DNA (mtDNA) alterations in breast cancer patients lacking mutation. possibility using the cancer-specific serum samples as blood-based test was also explored. Triple-matched (cancerous tissues, matched adjacent normal tissues samples) from were screened for mutations, methylation profile P14ARF , MDM2 PTEN genes analyzed well mtDNA...
Long non‑coding RNAs (lncRNAs) serve key roles in tumorigenesis and are differentially expressed cancer. Using bioinformatics statistical methods, the present study aimed to identify an lncRNA signature predict breast cancer survival. The gene expression data of 768 patients with were downloaded from Cancer Genome Atlas database, Cox regression, Kaplan‑Meier receiver operating characteristic (ROC) analyses performed construct validate a predictive model. Gene Ontology term enrichment Kyoto...
Introduction Adenylyl cyclase isoform 6 (ADCY6) is a member of membrane-bound adenylate family that converts adenosine triphosphate (ATP) into cAMP and pyrophosphate. An increasing number researchers have studied the role ADCY6 in cancer. However, its specific breast cancer remains unknown. Methods Bioinformatics clinical data were used to analyse expression DNA methylation was analysed using methylation-specific PCR Bisulfite Sanger sequencing. Using lentiviral stable miRNA transfection...
Enhancing virus multiplication could assist in the rapid production of vaccines against viral diseases. Cold atmospheric plasma (CAP), a physical approach relying on reactive oxygen species to achieve desirable cellular outcome, was shown be effective enhancing propagation, where bovine rhinotrachieitis and Madin-Darby Bovine Kidney cells were used as modeling cell line, respectively. CAP create synergies with infection arresting host at G2/M stage, decreasing membrane potential, increasing...
Background: Inflammatory breast cancer (IBC) is a rare type of with poor prognoses, moreover its pathogenesis not entirely clear. The aim this study was to identify key genes IBC, which might serve as diagnostic biomarkers and/or therapeutic targets. Methods: Two microarray datasets, GSE23720 and GSE45581, were obtained from the Gene Expression Omnibus database, differential expression analysis performed. ontology (GO) Kyoto Encyclopedia Genes Genomes (KEGG) enrichment analyses conducted...
Fibroblast growth factor receptor 1 (FGFR1) is widely recognized as a key player in mammary carcinogenesis and associated with the prognosis therapeutic response of breast cancers. With aim investigating correlation between FGFR1 expression estrogen (ER) exploring effect on endocrine therapy ER+ cancer prognosis, we examined protein among 184 ER-positive cancers by immunohistochemistry (IHC) method, analyzed association disease characters using Pearson’s chi-square test, assessed prognostic...
Inflammatory breast cancer (IBC) is a rare type of with poor prognosis, and the pathogenesis this life-threatening disease yet to be fully elucidated. This study aims identify key genes IBC, which could potential diagnostic or therapeutic targets.Four datasets GSE5847, GSE22597, GSE23720, GSE45581 were downloaded from Gene Expression Omnibus (GEO) differential expression analysis was performed. Ontology (GO) Kyoto Encyclopedia Genes Genomes (KEGG) enrichment analyses conducted understand...
To investigate the function of histone-lysine N-methyltransferase 2D (KMT2D) on methylation H3 lysine 4 (H3K4) in progression Ovarian cancer (OV). KMT2D, ESR1 and H3K4me expressions surgical resected tumors tumor adjacent tissues OV from 198 patients were determined using immunohistochemistry (IHC). Human cell lines including SKOV3, HO-8910 cells normal ovarian epithelial line IOSE80 employed for vitro experiment, BALB/C female nude mice used vivo study. qRT-PCR Western blotting implemented...
Cell-based vaccine manufacturing is an important strategy for viral disease prevention. Cultivating cells in suspension could maximize the utility of large bioreactors cost-effective and scaled up production, where adapting adherent to culture bottleneck key. Through whole transcriptome sequencing strains BHK-21 CHO-K1 followed by identification differentially expressed genes, mutational analysis, gene ontology, pathway enrichment we identified four candidate PABPC1, LARS, GLUL, PFN1,...
PURPOSE:To investigate associations between the clinicopathologic features and CT perfusion parameters of triple-negative breast cancer (TNBC) non-TNBC using low-dose computed tomography imaging (LDCTPI), to find potential clinical applications in prognosis assessment TNBC. MATERIALS AND METHODS:A total 60 patients with confirmed by pathological examination were studied prospectively LDCTPI on a 64-slice spiral scanner. The acquired volume data used for calculations, mapping, analysis tumor...
Objective To summarize the characteristics of BI-RADS 4a breast diseases under ultrasonic examination referring to patients’ clinical data and pathological reports. Methods 82 patients who were firstly-diagnosed treated in Affiliated Hospital Jiangnan University included. The ultrasonograms retrospectively reviewed along with correlated findings. Results 48 (58.5%) cases benign, among which fibroadenoma was most common. 34 (41.4%) malignant, invasive ductal carcinoma 68 82...