A5062768518- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Transplantation: Methods and Outcomes
- Neonatal Respiratory Health Research
- Asthma and respiratory diseases
- MicroRNA in disease regulation
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Inhalation and Respiratory Drug Delivery
- Fatty Acid Research and Health
- IL-33, ST2, and ILC Pathways
- Mechanical Circulatory Support Devices
- Respiratory viral infections research
- Pediatric health and respiratory diseases
- Respiratory Support and Mechanisms
- Cancer-related molecular mechanisms research
- Cardiac Structural Anomalies and Repair
- RNA modifications and cancer
- Extracellular vesicles in disease
- Congenital Diaphragmatic Hernia Studies
- Eicosanoids and Hypertension Pharmacology
- Colorectal Cancer Screening and Detection
- Neurogenetic and Muscular Disorders Research
- Viral Infections and Immunology Research
- Hematopoietic Stem Cell Transplantation
- Genetic factors in colorectal cancer
- Immune Cell Function and Interaction
Goethe University Frankfurt
2019-2024
University Hospital Frankfurt
2021-2023
Great Ormond Street Hospital
2012
University College London
2012
University of Göttingen
2005
University of Freiburg
2000-2004
University Medical Center Freiburg
2004
Uniwersytecki Szpital Dziecięcy
2004
Children's Clinical University Hospital
2004
Institut für Medizinische Biometrie, Informatik und Epidemiologie
2004
Lipid mediators derived from omega (n)-3 and n-6 long-chain polyunsaturated fatty acids (LCPUFA) play key roles in bronchoconstriction, airway inflammation, resolution processes asthma. This study compared the effects of dietary supplementation with either a combination LCPUFAs or eicosapentaenoic acid (EPA) alone to investigate whether has superior beneficial on outcome asthmatic mice. Mice were sensitized house dust mite (HDM) extract, subsequently supplemented EPA recall asthma model....
Abstract Rationale Bronchiolitis obliterans syndrome (BOS) is a severe, chronic inflammation of the airways leading to an obstruction bronchioles. So far, there are only few studies looking at long‐term development pulmonary impairment in children with BOS. Objective The objective this study was investigate incidence and outcome BOS who underwent allogeneic hematopoietic stem cell transplantation (HSCT). Methods Medical charts 526 undergoing HSCT Frankfurt/Main, Germany between 2000 2017...
Summary Several studies have investigated the association of a promoter polymorphism in CD14 with atopic phenotypes. We screened this and another 182 asthmatic children found no asthma. Furthermore, there was substantial linkage disequilibrium polymorphisms. Thus C D14 does not play major role development asthma our population Caucasian children.
Post-infectious bronchiolitis obliterans (PiBO) is a rare, chronic disease initiated by severe infection and followed perpetuating inflammation obliteration of the small airways. MicroRNAs (miRNAs) have been proposed to play central role as epigenetic regulators, which control resolution prevent uncontrolled progress inflammation. The aim this study was define biomarkers on level post-transcriptional gene regulation in order characterise PiBO.A total 39 patients with well-defined PiBO 31...
LCPUFAs are suggestive of having beneficial effects on inflammatory diseases such as asthma. However, little is known about the modulative capacity omega-(n)-3 and n-6 within epigenetic regulation processes. The aim this study was to investigate whether a specific combined LCPUFA supplementation restores disease-dysregulated miRNA-profiles in asthmatic mice. In addition, we determined effect interaction most regulated miRNA expression oxygenase activity vitro. Sequencing performed by NGS...
Bronchiolitis obliterans (BO) is a chronic disease in which persistent inflammation leads to obstruction and obliteration of the small airways. The aim this study was evaluate value calprotectin as an inflammatory marker induced sputum.Twenty-eight patients suffering from BO 18 healthy controls were examined. Lung function measured by spirometry, body plethysmography, lung clearance index (LCI). sputum obtained, cell counts performed, cytokines using cytometric bead array (CBA). Calprotectin...
microRNA (miR)-146a emerges as a promising post-transcriptional regulator in various inflammatory diseases with different roles for the two isoforms miR-146a-5p and miR-146a-3p. The present study aimed to examine dual role of miR-146a 3p modulation inflammation human pulmonary epithelial immune cells vitro well their expression patients lung diseases. Experimental A549, HL60, THP1 via NF-kB pathway resulted major upregulation miR-146a-3p expression, which was partly cell-specific. Modulation...
Introduction Acute exacerbations (AEs) increase morbidity and mortality of patients with chronic pulmonary diseases. Little is known about the characteristics impact AEs on children's interstitial lung disease (chILD). Methods The Kids Lung Register collected data AEs, clinical course quality life (patient-reported outcomes - PRO) rare paediatric Characteristics were obtained. Results Data 2822 2887 register visits 719 chILD recorded. characterised by increased levels dyspnoea (74.1%),...
Postinfectious bronchiolitis obliterans (PIBO) is a rare, chronic respiratory condition, which follows an acute insult due to severe infection of the lower airways.The objective this study was investigate long-term course bronchial inflammation and pulmonary function testing in children with PIBO.Medical charts 21 PIBO were analyzed retrospectively at Children's University Hospital Frankfurt/Main Germany. Pulmonary tests (PFTs) interval least 1 month studied between 2002 2019. A total 382...
Background Several studies have shown linkage of bronchial asthma, allergic rhinitis and total serum IgE concentration to the chromosomal region 12q13–24 in ethnical diverse populations. This harbours a number candidate genes for asthma atopy, including stem cell factor (SCF), leukotriene A4 hydrolase (LTA4H), thyroid receptor 2 (TR2), signal transducer activator transcription 6 (STAT6). However, same was as well be linked other diseases with inflammatory character. So far no variants any...
Introduction. Bronchiolitis obliterans (BO) is a chronic lung disease, which occurs after an insult to the lower airways, in particular airway infections or stem cell transplantation, and results persistent inflammation. N–3 n–6 polyunsaturated fatty acids (PUFA) have been shown influence inflammatory processes conditions. Since BO maintained by pulmonary inflammation, disbalanced n–6/n–3 acid profile could support process patients with therefore, become approach new therapeutic options....
Hypersensitivity pneumonitis (HP) in children is a severe interstitial lung disease and potentially, chronic condition, if not treated appropriately. No evidence-based guidelines are available; particular, the role of systemic glucocorticoid therapy unclear.The aim this randomized, double-blind, placebo-controlled, parallel-group, multi-center, phase II trial pediatric HP was to assess outcome after 6 months treatment compare 3 with oral prednisolone or placebo.After 1.5 years inclusion only...
Bronchiolitis obliterans (BO) is a rare and severe pulmonary disease which can occur due to airway infection or as result of stem cell lung transplantation. Our goal was study the function inflammation among BO patients. Furthermore, we examined potential clearance index (LCI) for diagnostics that group. 16 patients (age: 16.7; 9.6 - 25.3 years) 17 healthy controls 16.6; 7.6 25.0 participated in study. Lung parameters (FVC, FEV1, MEF25, RV und RV/TLC) well reversibility after administration...
<b>Background-Aim:</b> Data on malnutrition in childhood interstitial lung diseases (chILD) are scarce. We aimed to evaluate chILD and investigate factors leading poor nutritional status. <b>Methods:</b> source Kids Lung Register. From baseline follow-up data we analyzed parameters, severity scores, treatment modalities, PFT (ppFEV1 ppFVC) disease (using Fan score). <b>Results:</b> of 3,334 register visits from 759 children were included. At baseline, 94/759 (12%) had PEG/fundoplication. For...
<b>Background:</b> Calprotectin is found extensively in the cytoplasm of neutrophils and it released predominately inflammatory processes. locally which suggests that a sensitive indicator inflammation. Bronchiolitis Obliterans (BO) describes pathologic alteration small airways begins with an initial injury followed by distinctive response. <b>Aims:</b> The aim this study to investigate for first time what extent calprotectin increased sputum BO patients whether can be used as marker....
Zusammenfassung Einleitung Die Bronchiolitis obliterans (BO) ist eine sehr seltene, chronische Lungenerkrankung, die vereinzelt nach schweren Atemwegsinfektionen oder als Folge von Stammzell- und Lungentransplantation auftritt. Ziel der Arbeit war es, Lungenfunktion bronchiale Entzündung bei BO-Patienten im Jugend- Kindesalter zu untersuchen. Zudem sollte das Potenzial des LCI in Diagnostik dieser Patienten untersucht werden. Methoden Es wurden 16 (Alter:Median 16,7; 9,6–25,3 Jahre) 17...