A5072269526- Asthma and respiratory diseases
- Respiratory and Cough-Related Research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Allergic Rhinitis and Sensitization
- Pediatric health and respiratory diseases
- Neonatal Respiratory Health Research
- Fatty Acid Research and Health
- Inhalation and Respiratory Drug Delivery
- Cholesterol and Lipid Metabolism
- Eicosanoids and Hypertension Pharmacology
- Immune Cell Function and Interaction
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- DNA Repair Mechanisms
- Advanced Glycation End Products research
- Respiratory viral infections research
- Pharmaceutical studies and practices
- Adipose Tissue and Metabolism
- Respiratory Support and Mechanisms
- MicroRNA in disease regulation
- Carcinogens and Genotoxicity Assessment
- Food Allergy and Anaphylaxis Research
- Child and Adolescent Health
- Alcohol Consumption and Health Effects
- Transplantation: Methods and Outcomes
- Circular RNAs in diseases
University Hospital Frankfurt
2015-2025
Goethe University Frankfurt
2015-2025
Klinik und Poliklinik für Kinder- und Jugendmedizin
2022-2024
Center for Children
2021
Columbia University
2012-2019
Columbia University Irving Medical Center
2018
Martin Luther University Halle-Wittenberg
2012-2013
Columbia College
2012
Royal College of Physicians
2012
Johannes Gutenberg University Mainz
2007
Abstract Asthma is a chronic inflammatory disease mediated by allergen-specific CD4 T cells that promote lung inflammation through recruitment of cellular effectors into the lung. A subset can persist as tissue-resident memory (TRMs) following infection and allergen induction, although generation role TRM in asthma persistence pathogenesis remain unclear. In this study, we used mouse model exposure to intranasal house dust mite (HDM) extract dissect how TRMs are generated function allergic...
ABSTRACT Macrophage infiltration is common to both emphysema and atherosclerosis, cigarette smoke down‐regulates the macrophage cholesterol efflux transporter ATP binding cassette (ABC)A1. This decreased results in lipid‐laden macrophages. We hypothesize that adversely affects transport via an ABCA1‐dependent mechanism macrophages, enhancing TLR4/myeloid differentiation primary response gene 88 (Myd88) signaling resulting matrix metalloproteinase (MMP) up‐regulation exacerbation of pulmonary...
Abstract Objective Ligelizumab is a humanised IgG1 anti‐IgE antibody that binds IgE with higher affinity than omalizumab. had greater efficacy omalizumab on inhaled and skin allergen provocation responses in mild allergic asthma. This multi‐centre, randomised, double‐blind study was designed to test ligelizumab severe asthma patients not adequately controlled high‐dose corticoids plus long‐acting β2‐agonist. Methods Patients received 16 weeks (240 mg q2w), or placebo subcutaneously, ACQ‐7...
House dust mites (HDM) are the world's most important cause of allergic asthma. It is unclear why some patients with HDM allergy develop an early asthmatic reaction (EAR) only, whereas others react a dual reaction-EAR plus late (LAR). In LAR, symptoms and bronchial inflammation more severe, current knowledge suggests that EAR always precedes LAR. The aim present study was to investigate whether LAR can occur separately even without significant EAR. pilot 20 asthma allergy, allergen challenge...
Children with preschool asthma suffer disproportionally more often from severe exacerbations emergency visits and hospital admissions than school children. However, there are only a few reports on characteristics, hospitalization, phenotypes symptoms in this age cohort. This analysis of an ongoing prospective trial Tiotropium bromide preventing (the TIPP study) assessed baseline hospitalizations 100 children asthma. aged 1-5 years were analyzed at study enrollment daily recorded by...
Smokers with airflow obstruction have an increased risk of atherosclerosis, but the relationship between pathogenesis these diseases is not well understood. To determine whether hypercholesterolemia alters lung inflammation and emphysema formation, we examined phenotype two hypercholesterolemic murine models atherosclerosis at baseline on a high-fat diet. Airspace enlargement developed in lungs apolipoprotein E-deficient (Apoe(-/-)) mice exposed to Western-type diet for 10 wk. An elevated...
Lipid mediators derived from omega (n)-3 and n-6 long-chain polyunsaturated fatty acids (LCPUFA) play key roles in bronchoconstriction, airway inflammation, resolution processes asthma. This study compared the effects of dietary supplementation with either a combination LCPUFAs or eicosapentaenoic acid (EPA) alone to investigate whether has superior beneficial on outcome asthmatic mice. Mice were sensitized house dust mite (HDM) extract, subsequently supplemented EPA recall asthma model....
Abstract Background In preschoolers, performing an acceptable spirometry and measuring bronchodilator response (BDR) is challenging; in this context, impulse oscillometry (IOS) represents a valid alternative. However, more studies on the standardization of BDR for IOS young children are required. Objective The objective study was to identify optimal thresholds define positive test with preschoolers suspected asthma. Methods Children aged 3–6 years asthma their lung function investigated both...
Large conductance voltage- and calcium-activated potassium (BK) channels are highly expressed in airway smooth muscle (ASM). Utilizing the ovalbumin (OVA) house dust mite (HDM) models of asthma C57BL/6 mice, we demonstrate that systemic administration BK channel agonist rottlerin (5 μg/g) during challenge period reduced methacholine-induced hyperreactivity (AHR) OVA- HDM-sensitized mice (47% decrease peak resistance OVA-asthma animals, P<0.01; 54% HDM-asthma P<0.01) with a 35–40% reduction...
Asthma is a chronic inflammatory disease, which characterized by activation of CD4(+) T helper 2 cells orchestrating an allergic airway response. Whereas the role Wnt family members in regulating cell maintenance and maturation established, their contribution to asthma not known. We hypothesized that Wnt10b plays modulation response affects polarization. Using vivo house dust mite model, Wnt10b-deficient (Wnt10b(-/-)) mice were allergen-sensitized inflammation, as well activation, was...
The immune-modulating potential of long-chain polyunsaturated fatty acids (LCPUFAs) based on their conversion into lipid mediators in inflammatory situations has been proven by several studies. Respecting the immune-modulative role bronchoconstriction, airway inflammation and resolution processes, LCPUFAs play an important asthma. To design a disease-specific most beneficial LCPUFA supplementation strategy, it is essential to understand how asthma alters profiles. Therefore, this study...
A high proportion of house dust mite (HDM)-allergic asthmatics suffer from both an early asthmatic reaction (EAR) and a late (LAR) which follows it. In these patients, allergic inflammation is more relevant. MiRNAs have been shown to play important role in the regulation asthma's pathology. The aim this study was analyze miRNA profile patients with mild asthma HDM allergy after bronchial allergen provocation (BAP). Seventeen EAR/no LAR 17 EAR plus LAR, determined by significant fall FEV1...
Abstract Objective Exercise induced laryngeal obstruction (EILO) is an important differential diagnosis to exercise bronchoconstriction (EIB) and diagnosed via continuous laryngoscopy while exercising (CLE). However, availability of CLE limited specialized centres. And without EILO often misdiagnosed as EIB. Therefore it essential carefully preselect potential candidates. Aim this study was investigate whether two short questionnaires -Asthma Control Test (ACT) Dyspnea Index (DI) evaluating...
microRNA (miR)-146a emerges as a promising post-transcriptional regulator in various inflammatory diseases with different roles for the two isoforms miR-146a-5p and miR-146a-3p. The present study aimed to examine dual role of miR-146a 3p modulation inflammation human pulmonary epithelial immune cells vitro well their expression patients lung diseases. Experimental A549, HL60, THP1 via NF-kB pathway resulted major upregulation miR-146a-3p expression, which was partly cell-specific. Modulation...
Abstract Background Asthma is a chronic inflammatory disease of the airways but recent studies have shown that alveoli are also subject to pathophysiological changes. This study was undertaken compare hydrogen peroxide (H 2 O ) concentrations in different parts lung using new technique fractioned breath condensate sampling. Methods In 52 children (9-17 years, 32 asthmatic patients, 20 controls) measurements exhaled nitric oxide (FE NO ), function, H (EBC) and asthma control test (ACT) were...
Significant risk factors for persistence of asthma later in life are family history allergies, early allergic sensitization and bronchial hyperresponsiveness (BHR). The evolution BHR young children without with house dust mite allergy (HDM) was investigated.In this retrospective analysis, electronic charts 4850 wheezy bronchitis between 2005 2018 were reviewed order to study all patients ≤6 years assessed by methacholine provocation tests (MCT) at least once (n = 1175). Patients more than...
Children with pre-school asthma suffer disproportionally more often from severe exacerbations emergency visits and hospital admissions compared to school children. Despite this high disease burden, there are only a few reports looking at particular cohort. Similarly, is little real-life research on the distribution of phenotypes personalized treatment discharge in age group.
The present study tested the hypothesis that maternal smoke exposure results in fetal lung growth retardation due to dysregulation various signaling pathways, including Wnt (wingless-related integration site)/β-catenin pathway. Pregnant female C57BL/6J mice were exposed cigarette (100–150 mg/m3) or room air, and offspring humanely killed on 12.5, 14.5, 16.5, 18.5 d post coitum (dpc). We assessed stereology with Cavalieri estimation; apoptosis proliferating cell nuclear antigen, TUNEL,...
Omalizumab is licensed for therapy in severe allergic asthma with an effect demonstrated after 8 weeks or longer treatment. As new applications omalizumab demand precise knowledge of the onset effects, objective this study was to determine time course early (EAR) and late reaction (LAR).Ten patients (IgE>300 IU/mL <700 IU/mL) a significant response allergen challenge were treated according approved dosing table. Bronchial provocations (BAP) repeated at 1, 2, 4, 8.EAR significantly reduced 4...