A5001399930- Congenital Heart Disease Studies
- Mechanical Circulatory Support Devices
- Cardiac Structural Anomalies and Repair
- Transplantation: Methods and Outcomes
- Cardiac pacing and defibrillation studies
- Heart Failure Treatment and Management
- Renal Transplantation Outcomes and Treatments
- Cardiovascular Issues in Pregnancy
- Polyomavirus and related diseases
- Viral-associated cancers and disorders
- Congenital heart defects research
- Neonatal and fetal brain pathology
- Cardiac Arrhythmias and Treatments
- Cardiovascular Effects of Exercise
- T-cell and B-cell Immunology
- Long-Term Effects of COVID-19
- Kawasaki Disease and Coronary Complications
- Cardiovascular Function and Risk Factors
- Pulmonary Hypertension Research and Treatments
- Vascular anomalies and interventions
- COVID-19 Clinical Research Studies
- Organ Transplantation Techniques and Outcomes
- SARS-CoV-2 and COVID-19 Research
- Cardiac electrophysiology and arrhythmias
- Cardiac, Anesthesia and Surgical Outcomes
University of Southern California
2022-2024
Children's Hospital of Los Angeles
2018-2024
Southern California University for Professional Studies
2024
Background Children hospitalized with acute decompensated heart failure (ADHF) frequently require intravenous vasoactive (IVV) support drugs and are at risk for adverse cardiovascular (ACV) outcomes. We wished to assess whether serial changes in B‐type natriuretic peptide (BNP) levels associated successful weaning off IVV and/or prespecified ACV outcomes children ADHF. Methods Results ADHF from 2005 2021 our institution were assessed BNP, of support, Changes BNP level evaluated using linear...
Introduction In solid-organ transplantation, human leukocyte antigen (HLA) donor-specific antibodies (DSA) are strongly associated with graft rejection, loss, and patient death. The predominant tests used for detecting HLA DSA before after transplantation single bead (SAB) assays. However, SAB assays may not detect directed against epitopes that represented in the SAB. prevalence potential impact of unrepresented expected to vary by ethnicity, but have been thoroughly investigated. To...
The US Pediatric Heart Allocation Policy (PHAP) was revised in March 2016, with the goal of reducing waitlist mortality. We evaluated hypothesis that these changes, which increased status exceptions, have worsened racial disparities outcomes.Children Transplant Study database listed for first heart transplant from January 2012 - June 2020 were included and stratified by listing before (Era 1) or after 2) PHAP revision.A total 4,089 children during study period. Compared white (n = 2648),...
Abstract Post‐transplant lymphoproliferative disorders (PTLD) are the main malignancy seen after pediatric heart transplant and a significant cause of morbidity mortality. Prior to development detailed guidelines, we sought identify trends in screening, diagnosis, treatment PTLD. All Pediatric Heart Transplant Society (PHTS) institutions were surveyed. No identifiable patient information was shared. From 56 PHTS centers, 22 responses received (39.3%). 100% agree PTLD cannot be diagnosed...
Abstract Background Brain magnetic resonance imaging (MRI) of infants with congenital heart disease (CHD) shows brain immaturity assessed via a cortical-based semi-quantitative score. Our primary aim was to develop an infant paralimbic-related subcortical-based dysmaturation score, dysplasia score (BDS), detect abnormalities in CHD and predict clinical outcomes. secondary validate our BDS preclinical mouse model hypoplastic left syndrome. Methods A subcortical BDS, derived from structural...
Background: Brain magnetic resonance imaging (MRI) of infants with congenital heart disease (CHD) shows brain immaturity assessed via a cortical-based semi-quantitative score. Our primary aim was to develop an infant paralimbic-related subcortical-based dysmaturation score, termed dysplasia score (BDS), detect abnormalities in CHD compared healthy controls and secondarily predict clinical outcomes. We also validated our BDS preclinical mouse model hypoplastic left syndrome. Methods: A...
<title>Abstract</title> Background Right ventricular systolic dysfunction (RVD) is not well-understood in pediatric heart failure. Objectives To describe clinical and imaging features of children with isolated RVD biventricular (BVD). Methods This a retrospective single-center study evaluating patients (< 21 years) anatomy on cardiac magnetic resonance (CMR) between 2015–2022. Echocardiographic, CMR, data were collected. We defined as right ejection fraction (RVEF) < 45% RVEF 35% was...
Background: The physiology of the Fontan circulation is consistent with chronic heart failure, characterized by elevated central venous pressure and reduced cardiac output. In adults conventional iron deficiency common associated increased morbidity mortality. However, data lacking on prevalence its relationship cardiovascular outcomes in pediatric patients circulation. Aim: To characterize between profiles measures health Hypothesis: Iron worse health. Methods: Cross-sectional study...
We report a case of 15-year-old girl who presented with atrial flutter and acute decompensated heart failure ultimately requiring cardiac support extracorporeal membrane oxygenation (ECMO).While the patient's dysfunction are believed to be related, spontaneous development is exceedingly rare in teenagers.While both arrhythmia can seen fulminant myocarditis, patient did not have clinical history or testing consistent myocarditis systemic inflammation.Upon her admission intensive care unit,...
Introduction: Modern tests for HLA antibodies usually involve single antigen reagents, but clinically significant may not be detected if their epitopes are included in the reagents. Reagents from two vendors were examined to determine coverage eight ethnic populations: Hispanic (HIS), Native American (NAM), African (AFA), Asian and Pacific Islander (API), Middle Eastern North Coast of Africa (MENA), European (EUR), mixed or unknown ethnicity (UNK). Methods: HLA-A, -B, -C, -DRB1 allele...
Introduction: The US Pediatric Heart Allocation Policy was recently revised with the goal of lowering waitlist mortality. Effective March 2016, these rules significantly changed requirements for priority status. We evaluated hypothesis that this change, which has led to an increase in status exceptions, worsened known racial disparities outcomes. Methods: Children Transplant Study database listed at a center from January 2012 - June 2020 were included and stratified by listing before (Era 1)...