A5102000451- RNA and protein synthesis mechanisms
- RNA modifications and cancer
- TGF-β signaling in diseases
- RNA Research and Splicing
- Bacteriophages and microbial interactions
- Viral Infections and Immunology Research
- Ubiquitin and proteasome pathways
- Dendrimers and Hyperbranched Polymers
- Bone fractures and treatments
- Advanced biosensing and bioanalysis techniques
- Animal Disease Management and Epidemiology
- Animal Virus Infections Studies
- Pluripotent Stem Cells Research
- Developmental Biology and Gene Regulation
- Advanced Chemical Sensor Technologies
- Protein Tyrosine Phosphatases
- Geoscience and Mining Technology
- RNA Interference and Gene Delivery
- Cell Adhesion Molecules Research
- Geomechanics and Mining Engineering
- DNA Repair Mechanisms
- Kruppel-like factors research
- Nerve injury and regeneration
- Mechanisms of cancer metastasis
- Video Analysis and Summarization
Zhejiang University
2012-2025
Jining Medical University
2024
Shandong University
2024
Zhejiang Cancer Hospital
2023
Shaoxing University
2023
Center for Life Sciences
2023
University of Rochester Medical Center
2008-2016
Shanghai Normal University
2007-2014
Cappadocia University
2008-2010
Shaanxi Research Association for Women and Family
2009
An enzyme safeguards antiviral recognition machinery to avoid leaking and excessive danger response.
Smad7 is a negative feedback product of TGF-β superfamily signaling and fine tunes plethora pleiotropic responses induced by ligands. However, its noncanonical functions independent remain to be elucidated. Here, we show that activates signal transducers activators transcription 3 (STAT3) in maintaining mouse embryonic stem cell pluripotency manner the receptors, yet dependent on leukemia inhibitory factor (LIF) coreceptor glycoprotein 130 (gp130). directly binds intracellular domain gp130...
Crosslinking immunoprecipitation sequencing (CLIP-seq) technologies have enabled researchers to characterize transcriptome-wide binding sites of RNA-binding protein (RBP) with high resolution. We apply a soft-clustering method, RBPgroup, various CLIP-seq datasets group together RBPs that specifically bind the same RNA sites. Such combinatorial clustering helps interpret data and suggests functional regulatory elements. Furthermore, we validate two RBP–RBP interactions in cell lines. Our...
<title>Abstract</title> The rise of food delivery culture has resulted in millions tons food-contact plastic containers being used each year, yet the risks micro(nano)plastics (MNPs) released during storage oil-rich foods are still not well understood. Here, we investigated MNP release from polypropylene (PP) and polyethylene (PE)-coated under simulated takeout scenarios. When exposed to cooking oil microwave heating, up 125-fold more MNPs 471-fold heavy metals compared water exposure, with...
Abstract The cotton aphid, Aphis gossypii Glover (Homoptera: Aphididae), is an important pest in northern China, especially the seedling stage of cotton. After large scale commercial use transgenic Bt cotton, aphids became one most pests. A 2‐year study was conducted to evaluate role four winter wheat varieties that were resistant or susceptible Sitobion avenae Fabricius conserving arthropod natural enemies and suppressing a wheat–cotton relay intercropping system China. results indicated...
Bone morphogenetic proteins (BMPs) play vital roles in regulating stem cell maintenance and differentiation. BMPs can induce osteogenesis inhibit myogenesis of mesenchymal cells. Canonical BMP signaling is stringently controlled through reversible phosphorylation nucleocytoplasmic shuttling Smad1, Smad5, Smad8 (Smad1/5/8). However, how the nuclear export Smad1/5/8 regulated remains unclear. Here we report that Ran-binding protein RanBP3L acts as a factor for Smad1/5/8. directly recognizes...
The bone morphogenetic protein (BMP) signaling pathway regulates a wide range of cellular responses in metazoans. A key step the canonical BMP is phosphorylation and activation transcription factors Smad1, Smad5, Smad8 (collectively Smad1/5/8) by type I receptors. We previously identified PPM1A as phosphatase toward dephosphorylation all receptor-regulated Smads (R-Smads), including Smad1/5/8. Here we report another nuclear named SCP4/CTDSPL2, belonging to FCP/SCP family, novel Smad nucleus....
Mutually exclusive splicing is an important means of increasing the protein repertoire, by which Down's syndrome cell adhesion molecule ( Dscam ) gene potentially generates 38,016 different isoforms in Drosophila melanogaster . However, regulatory mechanisms remain obscure due to complexity exon cluster. Here, we reveal a molecular model for regulation mutually serpent pre-mRNA based on competition between upstream and downstream RNA pairings. Such dual pairings confer fine tuning inclusion...
SNIP1 (Smad nuclear interacting protein 1) is a transcription repressor for the TGF-β and NF-κB signaling pathways through disrupting recruitment of co-activator p300. However, it unclear how functions in pathway are controlled. Our present studies show that covalently modified by small ubiquitin-like modifier (SUMO) vitro vivo at three lysine sites: Lys5, Lys30, Lys108, with Lys30 being major SUMO modification site. SUMOylation enhanced E3 ligase PIAS proteins inhibited proteases SENP1/2....
A large number of box H/ACA RNAs have been identified in human cells, and predicted to account for nearly all pseudouridylation sites rRNAs. However, the function these mammalian directing has verified experimentally only two cases. In this study, we used three vitro reconstitution systems, including yeast test seven guiding16 sites. Our results 12 sites; four predictions were incorrect. Further analyses indicated that components, stability hairpin structure harboring pocket, guide...
Pseudouridine (Ψ) has been identified in various types of RNAs, including mRNA, rRNA, tRNA, snRNA, and many other noncoding RNAs. We have previously shown that RNA pseudouridylation, like DNA protein modifications, can be induced by stress. For instance, growing yeast cells to saturation induces the formation Ψ93 U2 snRNA. Here, we further investigate this inducible modification. show switching from nutrient-rich medium different nutrient-deprived media (including water) results Using gene...
Abstract A rapid spectroscopic approach for whole‐organism fingerprinting of Fourier transform infrared (FT‐IR) spectroscopy was used to analyse 16 isolates from five closely related species Fusarium : F. graminearum , moniliforme nivale semitectum and oxysporum . Principal components analysis hierarchical cluster were study the clusters in data. On visual inspection both methods, spectra not differentiated into separate corresponding these unsupervised methods failed identify fungal...
Folding of the major population Tetrahymena intron RNA into catalytically active structure is trapped in a slow pathway. In this report, folding Candida albicans was investigated using trans-acting Ca.L-11 ribozyme as model. We demonstrated that both catalytic activity (k(obs)) and compact equilibrium are strongly dependent on Mg(2+) at physiological concentrations, with showing an Hill coefficient 3. Formation shown to occur very rapidly, subsecond time scale similar RNase T1 cleavage. Most...
Formation of the P3-P7 pseudoknot structure, core group I ribozymes, requires long-range base pairing. Study Tetrahymena ribozyme appreciates hierarchical folding large, multidomain RNA, in which folds significantly slower than do other domains. Here we explored formation Candida that has been reported to concertedly fold catalytically active structure with a rate constant 2 min −1 . We demonstrate occurs during rapid compaction, coincident many tertiary interactions ribozyme. A low...
Tri(ethylene glycol) derived, low molecular-weight dendrons with various amine end groups were synthesized and characterized for their properties of binding self-assembling RNA using the Candida ribozyme as a model molecule. These dendritic compounds form stable complexes well-defined nanoscale particles molecules via electrostatic interactions self-assembly process, while leaving other terminal tri(ethylene chain accessible targeting. This suggests that dendrimers this type hold great...