A5065204179- Phytochemistry and Biological Activities
- Natural product bioactivities and synthesis
- Phytochemicals and Antioxidant Activities
- Genomics, phytochemicals, and oxidative stress
- Cancer-related Molecular Pathways
- Cell death mechanisms and regulation
- Drug-Induced Hepatotoxicity and Protection
- Biological Activity of Diterpenoids and Biflavonoids
- Poxvirus research and outbreaks
- Cancer Cells and Metastasis
- Seaweed-derived Bioactive Compounds
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Inflammasome and immune disorders
- Helicobacter pylori-related gastroenterology studies
- Ubiquitin and proteasome pathways
- Effects of Radiation Exposure
- Pharmacological Effects of Natural Compounds
- Gastrointestinal motility and disorders
- Phenothiazines and Benzothiazines Synthesis and Activities
- Allelopathy and phytotoxic interactions
- Glutathione Transferases and Polymorphisms
- Liver Disease Diagnosis and Treatment
- Telomeres, Telomerase, and Senescence
- Phytochemical and Pharmacological Studies
- Advanced Chemical Sensor Technologies
Henan Agricultural University
2025
Jinan University
2018-2024
Southern University of Science and Technology
2020-2024
ShenZhen People’s Hospital
2018-2023
Shenzhen University
2020
Jinan University
2018
Xiamen University
2014-2015
Taichung Veterans General Hospital
1996
Inflammasome is an intracellular signaling complex of the innate immune system. Activation inflammasomes promotes secretion interleukin 1β (IL-1β) and IL-18 triggers pyroptosis. Caspase-1 -11 (or -4/5 in human) canonical non-canonical inflammasome pathways, respectively, are crucial for inflammasome-mediated inflammatory responses. Here we report that gasdermin D (GSDMD) another component inflammasomes. We discovered presence GSDMD protein nigericin-induced NLRP3 by a quantitative mass...
<italic>Lonicera japonica</italic> Thunb., possesses antiviral and hepatoprotective activities, is widely used as a health food in cosmetics.
Mounting evidence suggests that a number of host nuclear-resident proteins are indispensable for the replication picornaviruses, typical class cytoplasmic RNA viruses. Host nucleocytoplasmic transport is often hijacked by viruses to promote their in cytoplasm infected cells, and suppress innate immune response. However, little known about mechanisms which Senecavirus A (SVA) manipulates trafficking events infection. In this study, we combined subcellular fractionation with quantitative...
Low-dose radiation (LDR) can potentiate cellular metabolic activities or immune functions in vivo (hormesis), and render cells resistant to DNA chromosome damage caused by subsequent high-dose (adaptive response). Protein synthesis was required for these responses LDR. In the present study, early expression of proteins thymocytes response low-dose whole-body irradiation (LD-WBI) investigated. The novel previously existing found nucleus, cytoplasm, extracellular fluid at 4 hours after WBI...
Liver cancer, also known as primary liver is cancer that starts in the liver. JNU-144, a new meroterpenoid purified from Lithospermum erythrorhizon, has exhibited promising anticancer activity; however, molecular mechanisms of action JNU-144 on malignant cells remain unclear. Our studies revealed suppressed cell viability and proliferation hepatoma by downregulating mTOR activation. Meanwhile, activated intrinsic apoptosis pathway subsequently triggered apoptotic death SMMC-7721 cells. We...
Si-Wei-Qing-Gan-Tang (SWQGT) is a Chinese medicine formula that widely used as folk remedy of herbal tea for the treatment chronic hepatitis, like non-alcoholic steatohepatitis (NASH), around Ganzhou City (Jiangxi province, China). However, underlying mechanisms this against NASH are still unknown. This study aimed to explore effect and SWQGT NASH. A network pharmacology approach was predict potential Then rat model established by feeding methionine choline deficient (MCD) diet verify on in...
IntroductionJichuan decoction (JCD) is a well-known traditional Chinese medicinal formula that moistens the intestines and widely used for treatment of constipation in China. However, its effects mechanisms alleviating slow transit (STC) vivo remain unclear. We attempted to demonstrate effect JCD, with without essential oil (VO), on intestinal underlying molecular rats loperamide-induced STC.Materials methodsWater consumption, body weight, fecal water content, time first melena excretion,...
It is an effective strategy to treat tuberculosis by enhancing reactive oxygen species- (ROS-) mediated killing of Mycobacterium in macrophages, but there are no current therapeutic agents targeting this pathway. Honeysuckle has been used as the traditional medicine for treatment 1500 years. Japoflavone D (JFD) a novel biflavonoid isolated from promoting ROS accumulation Nrf2 pathway hepatocarcinoma cells. However, its activity kill M. macrophages and molecular mechanism not reported. Our...
Abstract Tuberculosis (TB), an infectious bacterial disease caused by Mycobacterium tuberculosis (Mtb), is a major cause of death worldwide. Multidrug-resistant TB remains public health crisis and thus novel effective treatments, such as host-directed therapies (HDTs), are urgently required to overcome the challenges infection. In this study, we evaluated 4 calcium modulators for their effects on Mtb growth in macrophages. Only flunarizine enhanced bactericidal ability macrophages against...
The data presented in this article are associated with the research entitled "Novel flavonoids from Lonicera japonica flower buds and validation of their anti-hepatoma hepatoprotective activity vitro studies" (Ge et al., 2018) [1]. aim was to provide NMR spectrum novel buds. Samples were isolated EtOAc fraction extracts, then dissolved DMSO-d6 before testing.
Hepatitis B virus X protein (HBx) is highly expressed in HBV-infected hepatocellular carcinoma (HCC) and upregulates transcriptional activation of telomerase reverse transcriptase (TERT). NHP2 a component the complex also increased HCC. However, whether could accelerate HCC caused by HBx overexpression remains unknown. This study intended to investigate effects knockdown on HBx-overexpressed uncover potential mechanism. Results showed that after overexpression, expression TERT was increased....
SummaryThe effect of acute thermal injury on subcutaneous oxidative stress, in anesthetized rats, was evaluated. A microdialysis probe implanted the tissue for continuous sampling interstitial fluids, and microdialysates were injected onto either an on-line or off-line high performance liquid chromatography system. Hydroxyl radicals, glutathione, ascorbic acid concentrations analyzed. Acute induced by skin contact a hot (90°C) iron bar 30 15 s. Subcutaneous hydroxyl radical production,...
Background: Alpinia officinarum Hance is valued as an edible medicinal plant. The rhizome widely reported to have anticancer activity whereas little information available on the aerial part. This study investigates chemical composition, proapoptotic and anti-osteoporosis activities of essential oil from parts A. (APEO). Methods: In this study, APEO was extracted by hydrodistillation analyzed using GC-MS. inhibitive 0 - 2.5 μL/mL. investigated MTT assay, while in vivo effect evaluated nude...