A5054415263- Dementia and Cognitive Impairment Research
- Nutrition and Health in Aging
- Frailty in Older Adults
- Mitochondrial Function and Pathology
- Health disparities and outcomes
- Nutritional Studies and Diet
- Health Systems, Economic Evaluations, Quality of Life
- Genetic Associations and Epidemiology
- Health, Environment, Cognitive Aging
- Dental Health and Care Utilization
- Vitamin D Research Studies
- Alzheimer's disease research and treatments
- Cancer, Hypoxia, and Metabolism
- Chronic Disease Management Strategies
- Neuroscience and Neuropharmacology Research
- Geriatric Care and Nursing Homes
- Schizophrenia research and treatment
- Bipolar Disorder and Treatment
- Olfactory and Sensory Function Studies
- Cancer survivorship and care
- Glioma Diagnosis and Treatment
- LGBTQ Health, Identity, and Policy
- Memory Processes and Influences
- Tissue Engineering and Regenerative Medicine
- Signaling Pathways in Disease
Norwegian University of Science and Technology
2019-2024
Levanger Hospital
2020-2024
University of Bergen
2024
University of Stavanger
2024
Norwegian Medical Association
2024
Nasjonalforeningen for Folkehelsen
2024
Stavanger Akuttmedisinfond for utdanning og forskning
2024
University of Oslo
2006-2024
Trondheim Kommune
2022
Norwegian Institute of Public Health
2022
Background: Having accurate, up-to-date information on the epidemiology of mild cognitive impairment (MCI) and dementia is imperative. Objective: To determine prevalence MCI in Norway using data from a large population-based study. Methods: All people 70 + years age, n = 19,403, fourth wave Trøndelag Health Study (HUNT4) were invited to participate study HUNT4 . Trained health personnel assessed participants tests at field station, homes, or their nursing home. Interviewers also completed...
Cardiorespiratory fitness is associated with risk of dementia, but whether temporal changes in cardiorespiratory influence the dementia incidence and mortality still unknown. We aimed to study change estimated over time incident dementia-related mortality, onset longevity after diagnosis healthy men women at baseline. linked data from prospective Nord-Trøndelag Health Study (HUNT) done Nord-Trøndelag, Norway Memory cause death registries (n=30 375). Included participants were apparently...
Abstract In the HUNT Study, all residents aged ≥20 years in Nord-Trøndelag region, Norway have been invited to repeated surveys since 1984-86. The study data may be linked local and national health registries. HUNT4 survey 2017-19 included 56 042 participants 107 711 neighboring Sør-Trøndelag region. enable more long-term follow-up, studies of life-course trajectories, within-family studies. New measures include body composition analysis using bioelectrical impedance; a one-week...
Literature on physical performance in older adults across the cognitive spectrum remains inconclusive, and knowledge differences between dementia subtypes is lacking. We aim to identify distinct physical-performance deficits subtypes. 11,466 persons were included from 70-year-and-older cohort fourth wave of Trøndelag Health Study (HUNT4 70+). Physical was assessed with Short Performance Battery (SPPB), 4-meter gait speed, five-times-sit-to-stand (FTSS), grip strength one-leg-standing (OLS)....
To study the relationships of serum 25-hydroxyvitamin D [25(OH)D] with dental caries and periodontitis in a general Norwegian adult population. We analysed subsample 1605 participants from Trøndelag Health Study (HUNT) Norway that had 25(OH)D) levels measured HUNT3 (2006-08) oral health assessed HUNT4 Oral (2017-19). Negative binomial Poisson regression models were used to estimate ratios means (RMs; for count outcomes) prevalence (PRs; dichotomous outcomes). Serum 25(OH)D was inversely...
Background: A timely diagnosis of dementia can be beneficial for providing good support, treatment, and care, but the diagnostic rate remains unknown is probably low. Objective: To determine to describe factors associated with diagnosed dementia. Methods: This registry linkage study linked information on research-based diagnoses all-cause subtypes dementias, Alzheimer’s disease, related in 1,525 participants from a cross-sectional population-based (HUNT4 70+) both primary-care hospital...
The discovery of stem cells in the adult human brain has revealed new possible scenarios for treatment sick or injured brain. Both clinical use and preclinical research on neural have, however, been seriously hampered by fact that it impossible to passage these more than a very few times with little expansion cell numbers. Having explored number alternative culturing conditions we here present an efficient method establishment propagation from whatever tissue samples have tried. We describe...
Abstract Background Population-based studies on physical performance provide important information older people’s health but rarely include the oldest and least-healthy segment of population. The aim this study was to representative estimates by age, sex, educational level based recent data from a population-based in Norway that includes people with wide range age function. Methods In fourth wave Trøndelag Health Study (2017–2019), all participants aged 70 + were invited an additional...
Background: Studies exploring the possible protective effect of coffee and tea consumption on dementia have shown inconsistent results so far. We aimed to investigate whether different types at midlife are associated with later in life sex or ApoE4 influence such association. Methods: included 7381 participants from Norwegian HUNT Study. Self-reported questionnaires assessed daily baseline. After 22 years, individuals 70 years older were screened for cognitive impairment. Results: General...
Glioblastoma (GBM) is the most common primary brain malignancy and confers a dismal prognosis. GBMs harbor glioblastoma-initiating cells (GICs) that drive tumorigenesis contribute to therapeutic resistance tumor recurrence. Consequently, there strong rationale target this cell population in order develop new molecular therapies against GBM. Accumulating evidence indicates Nα-terminal acetyltransferases (NATs), are dysregulated numerous human cancers, can serve as targets. Microarrays were...
The Mini-Mental State Examination (MMSE), a simple test for measuring global cognitive function, is frequently used to evaluate cognition in older adults. To decide whether score on the indicates significant deviation from mean score, normative scores should be defined. Moreover, because may vary depending its translation and cultural differences, established national versions of MMSE.We aimed examine third Norwegian version data two sources: Registry Persons Assessed Cognitive Symptoms...
The biology of glioblastoma invasion and its mechanisms are poorly understood. We demonstrate using time-lapse microscopy that grafting (GBM) tumorspheres into rodent brain slices results in experimental ex vivo tumors with invasive properties recapitulate the observed after orthotopic transplantation brain. migratory movements mitotic patterns were clearly modified by signals extrinsic to invading cells. cells migrated away from tumorspheres, removal spheres reduced directed movement. cell...
BackgroundThe Personal Activity Intelligence (PAI) translates heart rate during daily activity into a weekly score. Obtaining PAI score ≥100 is associated with reduced risk of premature morbidity and mortality from cardiovascular diseases. Here, we determined whether changes in are incident dementia dementia-related mortality.MethodsWe conducted prospective cohort study 29,826 healthy individuals. Using data the Trøndelag Health-Study (HUNT), was estimated 10 years apart (HUNT1 1984–86 HUNT2...
Background Malnutrition is common in older adults and associated with increased morbidity mortality rates. Aim The aim of the study to describe prevalence malnutrition based on low BMI, involuntary weight loss, reduced food intake, a Norwegian population community-dwelling living nursing homes. Methods This population-based part fourth wave Trøndelag Health Study (HUNT4) includes participants ≥70 years from HUNT4 70+ cohort. cohort consist 9 930 (response rate 51.2 %) participants. In...
Background: Studies exploring the possible protective effect of coffee and tea consumption on dementia showed inconsistent results so far. We aimed to investigate whether different types at midlife are associated with later in life and, sex or ApoE4 influence such association.
 Methods: included 7381 participants from Norwegian HUNT Study. Self-reported questionnaires assessed daily baseline. After 22 years, individuals 70 years older were screened cognitive impairment. 
 Results:...
We aimed to investigate the associations between age at radical prostate cancer treatment and long-term global quality of life (QoL), physical function (PF), treatment-related side effects. This single-center, cross-sectional study included men treated for localized with robotic-assisted prostatectomy (RARP) or external beam radiotherapy (EBRT) in 2014-2018. Global QoL PF were assessed by European Organisation Research Treatment Cancer Quality Questionnaire-C30 (QLQ-C30), effects Expanded...
Abstract INTRODUCTION Individuals with Alzheimer's disease (AD) commonly experience neuropsychiatric symptoms of psychosis (AD+P) and/or affective disturbance (depression, anxiety, irritability, AD+A). This study's goal was to identify the genetic architecture AD+P and AD+A, as well their genetically correlated phenotypes. METHODS Genome‐wide association meta‐analysis 9988 AD participants from six source studies characterized for a joint phenotype (AD+A+P). RESULTS AD+A were correlated....
High blood pressure is a well-established risk factor of dementia. However, the timing remains controversial. The aim present study was to compare trajectories systolic (SBP) over 35-year follow-up period in Health Survey Trøndelag (HUNT) from wave 1 4 people with and without dementia diagnosis at (HUNT4). This retrospective cohort participants aged ≥ 70 years HUNT4, where 9,720 were assessed for In HUNT all residents 20 have been invited four surveys: HUNT1 1984-86, HUNT2 1995-97, HUNT3...
There is conflicting evidence regarding the association between vitamin D status and cognitive function in population studies. The use of one-time measurement health studies may not reflect long-term body.