Luke Gamble

ORCID: 0000-0003-3095-5935
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About
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Research Areas
  • Rabies epidemiology and control
  • Virology and Viral Diseases
  • Viral Infections and Outbreaks Research
  • Microbial infections and disease research
  • Human-Animal Interaction Studies
  • Poxvirus research and outbreaks
  • Helminth infection and control
  • Zoonotic diseases and public health
  • Yersinia bacterium, plague, ectoparasites research
  • Animal Behavior and Welfare Studies
  • Veterinary Equine Medical Research
  • Genetic and phenotypic traits in livestock
  • Streptococcal Infections and Treatments
  • Veterinary Practice and Education Studies
  • Veterinary Orthopedics and Neurology
  • Parasites and Host Interactions
  • Agricultural Engineering and Mechanization
  • Viral Infections and Vectors
  • Data-Driven Disease Surveillance
  • Sustainable Agricultural Systems Analysis
  • Innovations in Medical Education
  • Tendon Structure and Treatment
  • Effects of Environmental Stressors on Livestock
  • Advanced Malware Detection Techniques
  • Gothic Literature and Media Analysis

Worldwide Veterinary Service
2014-2025

Voluntary Health Association of Goa
2024

Universiti Putra Malaysia
2023

National Center for Emerging and Zoonotic Infectious Diseases
2023

Centers for Disease Control and Prevention
2023

Roslin Institute
2019-2023

University of Edinburgh
2023

Christian Aid
2023

Swiss Tropical and Public Health Institute
2023

Universitas Muhammadiyah Kupang
2023

Abstract Dog-mediated rabies kills tens of thousands people each year in India, representing one third the estimated global burden. Whilst World Health Organization (WHO), for Animal (OIE) and Food Agriculture United Nations (FAO) have set a target dog-mediated human elimination by 2030, examples large-scale dog vaccination programs demonstrating remain limited Africa Asia. We describe development data-driven program from 2013 to 2019 Goa State, culminating 92% reduction monthly canine...

10.1038/s41467-022-30371-y article EN cc-by Nature Communications 2022-05-19

Canine transmitted rabies kills an estimated 59,000 people annually, despite proven methods for elimination through mass dog vaccination. Challenges in directing and monitoring numerous remote vaccination teams across large geographic areas remain a significant barrier to the up-scaling of focal programmes sub-national national level. Smartphone technology (mHealth) is increasingly being used enhance coordination efficiency public health initiatives developing countries, however examples...

10.1371/journal.pone.0200942 article EN public-domain PLoS ONE 2018-07-26

Over 20 000 people die from rabies each year in India. At least 95 % of contract an infected dog. Annual vaccination over 70 the dog population has eliminated both canine and human many countries. Despite having highest burden world, there have been very few studies which reported successful, large scale dogs Furthermore, Indian programmes not achieved high vaccine coverage. In this study, we utilised a catch-vaccinate-release approach programme 18 wards Ranchi, Following vaccination,...

10.1186/s12879-015-1320-2 article EN cc-by BMC Infectious Diseases 2015-12-01

An estimated 60,000 people die of rabies annually. The vast majority cases human develop following a bite from an infected dog. Rabies can be controlled in both and canine populations through widespread vaccination dogs. is particularly problematic Malawi, costing the country 13 million USD 484 deaths annually, with increasing paediatric incidence Blantyre City. Consequently, aim this study was to vaccinate minimum 75% all dogs within city during one month period. Blantyre’s 25...

10.1371/journal.pntd.0004824 article EN cc-by PLoS neglected tropical diseases 2016-07-14

Rabies has profound public health, social and economic impacts on developing countries, with an estimated 59,000 annual human rabies deaths globally. Mass dog vaccination is effective at eliminating the disease but remains challenging to achieve in India due high proportion of roaming dogs that cannot be readily handled for parenteral vaccination. Two methods could not injection were compared Goa, India; oral bait handout (OBH) method, where teams two travelled by scooter offering empty...

10.1016/j.jvacx.2019.100015 article EN cc-by-nc-nd Vaccine X 2019-03-01

Introduction Dog vaccination against rabies is considered one of the most effective strategies at preventing human deaths from and a key strategy for eliminating dog-mediated deaths. Traditional approaches in Zambia rarely collect operational data to assess coverage inform subsequent campaigns. Methods Following mass campaigns rural (Itezhi tezhi) urban (Lusaka) communities, we evaluated achieved during characterized estimated dog population these communities. Results Herd immunity (i.e.,...

10.3389/fvets.2024.1492418 article EN cc-by Frontiers in Veterinary Science 2025-01-20

Abstract Veterinarians are custodians of animal welfare, ensuring practices remain current and effective in the face ever-changing demands profession. Continuing Professional Development (CPD) is essential for protecting however access to quality CPD a challenge many countries. India has one fastest growing veterinary industries globally, emphasising importance accessible opportunities that relevant this setting. This study used focus groups explore how Indian veterinarians identify CPD,...

10.1017/awf.2025.3 article EN cc-by-nc-nd Animal Welfare 2025-01-01

Rabies is a devastating yet preventable disease that causes around 59,000 human deaths annually. Almost all rabies cases are caused by bites from rabies-infected dogs. A large proportion of these occur in Sub Saharan Africa (SSA). Annual vaccination at least 70% the dog population recommended World Health Organisation order to eliminate rabies. However, achieving such high coverage has proven challenging, especially low resource settings. Despite being logistically and economically more...

10.1371/journal.pntd.0006159 article EN cc-by PLoS neglected tropical diseases 2018-01-11

Rabies is an important neglected disease, which kills around 59,000 people a year. Over third of these deaths are in children less than 15 years age. Almost all human rabies Africa and Asia due to bites from infected dogs. Despite the high efficacy current vaccines, awareness about preventive healthcare often low endemic areas. It therefore common for educational initiatives be conducted conjunction with other control activities such as mass dog vaccination, however there few examples where...

10.1371/journal.pntd.0006293 article EN cc-by PLoS neglected tropical diseases 2018-03-09

Dogs harbor numerous zoonotic pathogens, many of which are controlled through vaccination programs. The delivery these programs can be difficult where resources limited. We developed a dynamic model to estimate coverage and cost-per-dog vaccinated. considers the main factors that affect programs: dog demographics, effectiveness strategies, efficacy interventions cost. was evaluated on data from 18 representing eight countries. Sensitivity analysis performed for confinement strategies....

10.1017/s0950268819001158 article EN cc-by-nc-sa Epidemiology and Infection 2019-01-01

Free-roaming dogs (FRD) represent a large proportion of the canine population in India and are often implicated as source conflict with humans. However, objective data on attitudes perceptions local communities toward FRD lacking. This study collected baseline from 1141 households Goa, India, feeding practices assessed people's urban rural communities. Additionally, respondents identified problems caused by proposed potential solutions.The reported that 37% fed dog owners Hindus being most...

10.1080/10888705.2021.2014839 article EN Journal of Applied Animal Welfare Science 2022-01-17

Abstract Background Rabies is a fatal but preventable viral disease, which causes an estimated 59 000 human deaths globally every year. The vast majority of rabies cases are attributable to bites from infected domestic dogs and consequently control in the dog population through mass vaccination campaigns considered most effective method eliminating disease. Achieving WHO target 70% coverage has proven challenging low-resource settings such as Sub Saharan Africa, lack public awareness about...

10.1186/s40249-020-00677-4 article EN cc-by Infectious Diseases of Poverty 2020-06-05

Like other neglected diseases, surveillance data for rabies is insufficient and incompatible with the need to accurately describe burden of disease. Multiple modeling studies central estimating global human deaths have been conducted in last two decades, results ranging from 14,000 74,000 annually. Yet, uncertainty model parameters, inconsistency approaches, discrepancies quality per country included led recent skepticism about magnitude mortality. Lack not only limits efficiency monitoring...

10.3389/fitd.2024.1303359 article EN cc-by Frontiers in Tropical Diseases 2024-03-26

Significance Rabies is arguably the exemplar of One Health Agenda in which preventative health care one species can improve other species. Interrogation large epidemiology datasets offers potential to deliver initiatives a more efficient and cost-effective manner. However, real-life examples demonstrating this are limited. Here, we report real-time, data-driven approach cost effectiveness dog vaccination campaigns urban sub-Saharan African settings, eliminates need expensive door-to-door by...

10.1073/pnas.2003722118 article EN cc-by Proceedings of the National Academy of Sciences 2021-01-18

Introduction: To achieve the global goal of canine-mediated human rabies elimination by 2030 there is an urgent need to scale-up mass dog vaccination activities in regions with large populations that are difficult access; a common situation much India. Oral may enable free-roaming dogs inaccessible parenteral vaccination, and considered promising complementary measure campaigns. WHO OIE have published detailed minimum requirements for vaccines baits be used this purpose, requiring must not...

10.3390/tropicalmed4030118 article EN cc-by Tropical Medicine and Infectious Disease 2019-09-04

Rabies is a devastating zoonotic disease causing nearly 60,000 deaths globally each year. The causes Malawi an economic loss of 13 million USD and kills almost 500 people annually. Domestic dogs are the main reservoir for rabies vaccinating over 70% dog population most efficient method to reduce its incidence in both humans canines. However, achieving such coverages often difficult depend on many geospatial factors. Rural pastoral regions considered vaccinate efficiently due low densities,...

10.1371/journal.pntd.0008004 article EN cc-by PLoS neglected tropical diseases 2020-01-23

Rabies is estimated to cause 59,000 deaths and economic losses of US$8.6 billion every year. Despite several years rabies surveillance awareness programmes, increased availability post-exposure prophylaxis vaccinations dog population control, the disease still remains prevalent in Sri Lanka. This study reports roll-out a high number, coverage canine vaccination campaign Lanka, providing estimates for achieved, analysing local demographics, identifying barriers attendance static clinics.A...

10.1186/s12879-019-4585-z article EN cc-by BMC Infectious Diseases 2019-11-20

The effective management of stray dogs is critically important in any rabies vaccination programme. In many rabies-endemic countries, represent a significant proportion both the free-roaming and total dog populations, to ensure that elimination programmes are successful, it essential this portion population (stray dogs) vaccinated at high coverage. However, there number challenges managing delivering vaccinations dogs. This paper will review most pertinent issues relating problem...

10.20506/rst.37.2.2822 article FR Revue Scientifique et Technique de l OIE 2018-08-01
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