A5010411056- Nanoplatforms for cancer theranostics
- Cancer, Hypoxia, and Metabolism
- Cancer-related gene regulation
- Chromatin Remodeling and Cancer
- Heme Oxygenase-1 and Carbon Monoxide
- Epigenetics and DNA Methylation
- Cancer-related molecular mechanisms research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- FOXO transcription factor regulation
- Cancer Mechanisms and Therapy
- Proteoglycans and glycosaminoglycans research
- Photodynamic Therapy Research Studies
Kaohsiung Medical University
2017-2022
Kaohsiung Medical University Chung-Ho Memorial Hospital
2017-2021
Abstract MRE11, the nuclease component of RAD50/MRE11/NBS1 DNA repair complex which is essential for double-strand-breaks in normal cells, has recently garnered attention as a critical factor solid tumor development. Herein we report crucial role MRE11 oral cancer progression nuclease-independent manner and delineate its key downstream effectors including CXCR4. expression samples was positively associated with size, stage lymph node metastasis, predictive poorer patient survival...
Oral cancer is a common with high mortality rate. While surgery the most effective treatment for oral cancer, it frequently causes deformity and dysfunction in orofacial region. In this study, methyl aminolevulinate photodynamic therapy (MAL-PDT) as prevention tool against progression of precancerous lesion to was explored.For vitro studies, we evaluated effects MAL-PDT on viability DOK cells by XTT, cell morphology TEM, intracellular signaling pathways flow cytometry, Western blotting,...
Oral cancer is one of the highest-incidence malignancies worldwide, with occurrence oral squamous cell carcinoma (OSCC) being most frequently diagnosed form. A barrier for management may arise from tumor cells that possess properties stemness, which has been recognized as a crucial factor in recurrence and metastasis. As such, understanding molecular mechanisms underlying these provide insights improving treatment. MRE11 core protein RAD50/MRE11/NBS1 complex primary role DNA damage repair,...