A5100387224- Hepatitis B Virus Studies
- Ferroptosis and cancer prognosis
- Cancer Immunotherapy and Biomarkers
- Hepatitis C virus research
- Liver Disease Diagnosis and Treatment
- RNA Interference and Gene Delivery
- Atherosclerosis and Cardiovascular Diseases
- RNA modifications and cancer
- Advanced biosensing and bioanalysis techniques
- Epigenetics and DNA Methylation
- SARS-CoV-2 and COVID-19 Research
- Renal Diseases and Glomerulopathies
- Viral gastroenteritis research and epidemiology
- Cancer-related molecular mechanisms research
- Microbial metabolism and enzyme function
- Cancer-related gene regulation
- COVID-19 Clinical Research Studies
- Chronic Kidney Disease and Diabetes
- Systemic Lupus Erythematosus Research
- Pancreatic and Hepatic Oncology Research
- MicroRNA in disease regulation
- Acute Kidney Injury Research
- Kruppel-like factors research
- Genetic factors in colorectal cancer
- Nanopore and Nanochannel Transport Studies
Tianjin Medical University
2021-2024
Tianjin Fire Research Institute
2023-2024
Tianjin International Joint Academy of Biomedicine
2023-2024
Tianjin Third Central Hospital
2021-2024
Wenzhou Medical University
2021-2024
First Affiliated Hospital of Wenzhou Medical University
2022-2024
Henan Provincial People's Hospital
2023-2024
Zhengzhou University
2023-2024
The First Hospital of Changsha
2023
University of Science and Technology of China
2022-2023
Shc SH2-domain binding protein 1 (SHCBP1), a specific to SH2 domain of Src homolog and collagen (Shc), takes part in the regulation various signal transduction pathways, which has been reported be associated with tumorigenesis progression. However, pathological mechanisms are not completely investigated. Thus, this study aimed comprehensively elucidate potential functions SHCBP1 multiple cancer types. The comprehensive analyses for tumors, including gene expression, diagnosis, prognosis,...
Background Lupus nephritis (LN) is the most common and severe clinical manifestation of systemic lupus erythematosus (SLE) with considerable morbidity/mortality limited treatment options. Since kidney biopsy a relative hysteretic indicator, it indispensable to investigate potential biomarkers for early diagnosis predicting outcomes LN patients. Extracellular proteins may become promising by secretion into body fluid. Our study linked extracellular identify emerging biomarkers. Methods The...
Abstract Background As the most common subtype in lung cancer, precise and efficient treatment for non-small cell cancer (NSCLC) remains an outstanding challenge owing to early metastasis poor prognosis. Chemotherapy, commonly used modality, is a difficult choice many patients due insufficient drug accumulation tumor sites severe systemic side-effects. In this study, we constructed cell-specific aptamer-modified DNA nanostructure (Apt-NS) as targeting delivery system achieving precision...
Background Polyamines metabolism is closely related to tumor development and progression, as well microenvironment (TME). In this study, we focused on exploring whether polyamines metabolism-associated genes would provide prognosis immunotherapy response prediction in lung adenocarcinoma (LUAD). Methods The expression profile data of were acquired from the Cancer Genome Atlas (TCGA) database. Utilizing least absolute shrinkage selection operator (LASSO) algorithm, created a risk score model...
To test the hypothesis that chronic hypoxic pulmonary hypertension (CH-PH) is associated with increased survivin and decreased voltage-gated potassium (KV) channels expression in arteries, rats were randomized as: normoxia (N); + YM155, suppressor (NY); hypoxia (H); YM155 (HY). HY group had significantly reduced arterial pressure, right ventricular weight hypertrophy compared H group. Survivin mRNA protein detected arteries of CH-PH, but not without CH-PH. downregulated mRNA. KV channel...
IgA nephropathy (IgAN), the most common type of glomerulonephritis worldwide, can only be diagnosed mainly by renal biopsy owing to lack effective biomarkers. It is urgent explore and identify potential diagnostic biomarkers through assessing gene expression profiles patients with IgAN.Two datasets were obtained from Gene Expression Omnibus (GEO) database, including GSE115857 (55 IgAN, 7 living healthy donors) GSE35487 (25 6 donors), then underwent differentially expressed genes (DEGs)...
ADP-ribosylation factor (Arf)-GTPase-activating protein (GAP) with coiled-coil, ankyrin repeat and PH domains 1 (ACAP1) has been reported to serve as an adaptor for clathrin coat complex playing a role in endocytic recycling cellular migration. The potential of ACAP1 lung adenocarcinoma (LUAD) not yet completely defined. We performed the comprehensive analyses, including gene expression, survival analysis, genetic alteration, function enrichment, immune characteristics. was remarkably...
Abstract Background The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is identified as the cause of disease 2019 (COVID-19) pandemic. Acute kidney injury (AKI), one serious complications COVID-19 infection, leading contributor to renal failure, associating with high mortality patients. This study aimed identify shared gene signatures and construct regulatory network between AKI, contributing exploring potential pathogenesis. Methods Utilizing machine learning...
Disulfidptosis, a novel form of regulated cell death, occurs due to the aberrant accumulation intracellular cystine and other disulfides. Moreover, targeting disulfidptosis could identify promising approaches for cancer treatment. Long non-coding RNAs (lncRNAs) are known be critically implicated in clear renal carcinoma (ccRCC) development. Currently, involvement disulfidptosis-related lncRNAs ccRCC is yet elucidated. This study primarily dealt with identifying validating lncRNAs-based...
AIM:To design and establish a method of multiplex PCR normalization for simultaneously detecting HBV HCV. METHODS:Two pairs primers with 20 bp joint sequence were used to amplify the target genes HCV by two rounds amplification.After amplification all products had sequence.Then was as finish last amplification.Finally normalized single system eliminate factor interference.Four kinds nucleic acid extraction methods compared screened.A established optimized orthogonal 6 key factors.Then twenty...
With the deepening research on tumor microenvironment (TME), immunotherapy has been deemed to be one of major breakthroughs for cancer therapy. Nevertheless, only some patients respond well this treatment. It is vital explore predictive biomarkers clinical benefit immunotherapy. Grb2-associated binding protein 3 (GAB3) exerts essential biological functions in ovarian and colorectal cancer. The potential role GAB3 lung adenocarcinoma (LUAD) not fully elucidated. RNA-sequencing data, genetic...