A5100425748- Hypothalamic control of reproductive hormones
- Atherosclerosis and Cardiovascular Diseases
- Neuroinflammation and Neurodegeneration Mechanisms
- Mercury impact and mitigation studies
- Adipokines, Inflammation, and Metabolic Diseases
- Melamine detection and toxicity
- Cardiovascular Syncope and Autonomic Disorders
- Sports injuries and prevention
- Plant Reproductive Biology
- Neurological and metabolic disorders
- Biomedical Research and Pathophysiology
- Bone Metabolism and Diseases
- MicroRNA in disease regulation
- Phytoestrogen effects and research
- Connective tissue disorders research
- Iron Metabolism and Disorders
- Ovarian cancer diagnosis and treatment
- Foot and Ankle Surgery
- Autophagy in Disease and Therapy
- Neuropeptides and Animal Physiology
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Lower Extremity Biomechanics and Pathologies
- Electrolyte and hormonal disorders
- Ubiquitin and proteasome pathways
- Ovarian function and disorders
Children's Hospital of Zhejiang University
2009-2024
LinkedIn (United States)
2021
Zhejiang University
2013-2021
Academy of Military Medical Sciences
2016
Sun Yat-sen University
2009
Key Laboratory of Guangdong Province
2009
Abstract Context Although gonadotropin-releasing hormone stimulation test (GnRHST) is the gold standard in diagnosing central precocious puberty (CPP), it invasive, expensive, and time-consuming, requiring multiple blood samples to measure gonadotropin levels. Objective We evaluated whether urinary hormones could be potential biomarkers for prepuberty or postpuberty, aiming simplify current diagnosis prognosis procedure. Methods performed a cross-sectional study of total 355 girls with CPP...
Abstract Objective To analyze the MRI manifestations of and factors related to ankle injuries in asymptomatic amateur marathon runners. Materials methods A total 113 runners without any joint symptoms were recruited. Each participant was asked complete a questionnaire at beginning study underwent ankle. The summarized, binary logistic regression analysis applied injuries. Results main features bone marrow edema-like signal intensity, peritendinous effusion, partial lateral collateral...
Introduction This study was performed to investigate the role of iron overload in early stage hyperglycemia-induced vascular functional impairment. Research design and methods A total 196 obese children were enrolled, data regarding ferritin levels, blood glucose intima-media thickness carotid arteries, liver function fibrosis index, hemoglobin, pressure, lipids, inflammation indicators collected. Ferritin levels compared with a control group, which consisted 148 healthy non-obese who...
Objective: To investigate the role of mannose-binding lectin (MBL) in modulating autophagy and protecting endothelial cells (ECs) from oxidized low-density lipoprotein (ox-LDL)-induced injury. Methods: Serum MBL concentration carotid intima-media thickness (cIMT) were measured 94 obese 105 healthy children. ECs transfected with over-expression plasmid, LOX1 was knocked-down to explore protective ox-LDL induced Dendritic (DCs) co-cultured ECs, inflammatory factors, DC maturation, assessed. WT...
Objective. Our purpose is to describe the characteristics and outcome of melamine-induced renal urinary tract injury in young children who consumed melamine-contaminated infant formula. Methods. This a descriptive longitudinal study over 2 years 240 with urolithiasis screened our hospital from September 15 October 31, 2008. Ultrasonography serum creatinine (SCr), urea, β2-microglobulin (MG), cystatin C (Cys C), Cr (UCr), microalbumin (mALB), α1-MG, β2-MG, n-acetyl-β-d-glucosaminidase (NAG)...
Abstract Rationale: X-linked spondyloepiphyseal dysplasia tarda (X-linked SEDT) is a rare hereditary cause in childhood short stature due to mutations trafficking protein particle complex subunit 2 (TRAPPC2) gene located on chromosome Xp22. Several pathogenic variants TRAPPC2 have been reported, but missense are rare. Patient concerns: A 13-year, 8-month-old Chinese Han boy presenting with for the past 7 years. Diagnosis: SEDT was established by combination of clinical and radiographic...
Abstract Objective To investigate the role of mannose-binding lectin (MBL) in modulating autophagy and protecting endothelial cells (ECs) from oxidized low-density lipoprotein (ox-LDL) induced injury. Materials Methods Rapamycin chloroquine were used to confirm ox-LDL ECs Dendritic (DCs) co-cultured with ECs, after which inflammatory factors DCs maturation rate detected. Autophagy was detected by LC3 Lamp2a or autophagosomes. Cell viability analyzed Counting Kit-8 (CCK-8) assay. Flow...