A5026193578- Nanoparticles: synthesis and applications
- Bacterial biofilms and quorum sensing
- Advanced Nanomaterials in Catalysis
- Antimicrobial agents and applications
- Wound Healing and Treatments
- Nanoplatforms for cancer theranostics
- Lignin and Wood Chemistry
- Hydrogels: synthesis, properties, applications
- Biosensors and Analytical Detection
- Oral microbiology and periodontitis research
- Biofuel production and bioconversion
- Fermentation and Sensory Analysis
- Corneal Surgery and Treatments
- Enzyme Production and Characterization
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Bone Tissue Engineering Materials
- Nanoparticle-Based Drug Delivery
- Advanced Chemical Sensor Technologies
- Microplastics and Plastic Pollution
- Hops Chemistry and Applications
- Electrospun Nanofibers in Biomedical Applications
- Studies on Chitinases and Chitosanases
- Polymer composites and self-healing
- SARS-CoV-2 detection and testing
- Ocular Surface and Contact Lens
Universitat Politècnica de Catalunya
2018-2024
Universitat de Barcelona
2017
Pseudomonas aeruginosa bacteria originate severe infections in hospitalized patients and those with chronic debilitating diseases leading to increased morbidity mortality, longer hospitalization huge financial burden the healthcare system. The clinical relevance of P. is by capability this bacterium grow biofilms develop multidrug resistant mechanisms that preclude conventional antibiotic treatments. Herein, we engineered novel multimodal nanocomposites integrate same entity antimicrobial...
To palliate the appearance of antimicrobial resistance (AMR), use bactericidal agents acting differently than conventional antibiotics and elimination bacterial biofilm, are two most promising strategies. Here, we integrated these complementary strategies into new metal–enzyme nanoaggregates (NAs) α-amylase silver (αAgNAs) that able to eliminate bacteria their biofilm. The nanoparticle (NP) synthesis approach applied protein desolvation laccase-mediated NP stabilization innovatively produce...
Chronic wounds are persistent non-healing lesions whose complex management is due to the interplay of multiple factors promoting chronicity, such as oxidative stress, overexpressed enzyme activities impeding tissue repair and bacterial contamination. Currently marketed chronic wound dressings designed mainly absorb exudate, at most release antimicrobial agents, usually ionic silver. However, an effective requires addressing multifactorial nature in a holistic approach. This study explores...
As the most abundant renewable aromatic polymer on planet, lignin is gaining growing interest in replacing petroleum-based chemicals and products. However, only <5 % of industrial waste revalorized its macromolecular form as additives, stabilizing agents or dispersant surfactants. Herein, revalorization this biomass was achieved by implementing an environmentally-friendly continuous sonochemical nanotransformation to obtain highly concentrated nanoparticles (LigNPs) dispersions for...
Purpose: Lignin is the most abundant source of aromatic biopolymers and has gained interest in industrial biomedical applications due to reported biocompatibility defense provided against bacterial fungal pathogens, besides antioxidant UV-blocking properties. Especially form nanoparticles (NPs), lignin may display also anti-inflammatory activities. Methods: To evaluate these characteristics, sonochemically nano-formulated pristine (LigNPs) enzymatically-phenolated one (PheLigNPs) were used...
Silver nanoparticles (Ag NPs) appeared as promising antimicrobial candidates to face the development of antibiotic resistance. Although reported toxic towards mammalian cells, their combination with biomolecules have shown reduced toxicity, while maintaining function. Herein, hyaluronic acid (HA) low (40 kDa), medium (200 and 600 kDa) high (2 MDa) molecular weight (Mw) was modified adipic dihydrazide (ADH) used reducing capping agents synthesise hybrid Ag NPs. The Mw polymer played a crucial...
Current procedures for the assessment of chronic wound infection are time-consuming and require complex instruments trained personnel. The incidence wounds worldwide, associated economic burden, urge simple cheap point-of-care testing (PoCT) devices fast on-site diagnosis to enable appropriate early treatment. enzyme myeloperoxidase (MPO), whose activity in infected is about ten times higher than non-infected wounds, appears be a suitable biomarker diagnosis. Herein, we develop...
The wearing of contact lenses (CLs) may cause bacterial infections, leading in turn to more serious complications and ultimately vision impairment. In this scenario, the first step is adhesion tear proteins, which provide anchoring points for colonization. A possible solution functionalization with an antimicrobial coating, though latter also lead sight obstruction user discomfort. study, adipic acid dihydrazide-modified hyaluronic acid-cobalt (II) (HA-ADH-Co) nanogels (NGs) were synthesized...
Biomass fillers offer the possibility to modify mechanical properties of foams, increasing their cost-effectiveness and reducing carbon footprint. In this study, bio-based PU (soft, open cells for automotive sector) epoxy (EP, hard, closed construction applications) composite foams were prepared by adding pristine laccase-mediated lauryl gallate-hydrophobized hemp protein particles as filler (HP HHP, respectively). The able density, morphology EP foams. addition HP increases density up 100%...