A5011248500- Bacterial biofilms and quorum sensing
- Antimicrobial agents and applications
- Biosensors and Analytical Detection
- Nanoparticles: synthesis and applications
- Urinary Tract Infections Management
- Antimicrobial Peptides and Activities
- Wound Healing and Treatments
- Inhalation and Respiratory Drug Delivery
- Antibiotic Resistance in Bacteria
- Bacteriophages and microbial interactions
- Analytical Chemistry and Sensors
- Central Venous Catheters and Hemodialysis
- Electrochemical sensors and biosensors
- Plant tissue culture and regeneration
- Microplastics and Plastic Pollution
- Advanced Chemical Sensor Technologies
- Innovative Microfluidic and Catalytic Techniques Innovation
- Microbial Metabolic Engineering and Bioproduction
- Advancements in Transdermal Drug Delivery
- Dental Research and COVID-19
- Nanoplatforms for cancer theranostics
- Skin Protection and Aging
- Essential Oils and Antimicrobial Activity
- Polymer Surface Interaction Studies
- Electrospun Nanofibers in Biomedical Applications
Universitat Politècnica de Catalunya
2016-2025
Tula State University
2024
Food Research and Development Institute
2021
The emergence of bacteria resistant to antibiotics and the resulting infections are increasingly becoming a public health issue. Multidrug-resistant (MDR) responsible for leading increased morbidity mortality in hospitals, prolonged time hospitalization, additional burden financial costs. Therefore, there is an urgent need novel antibacterial agents that will both treat MDR outsmart bacterial evolutionary mechanisms, preventing further resistance development. In this study, green synthesis...
Bacteria often colonize in-dwelling medical devices and grow as complex biofilm communities of cells embedded in a self-produced extracellular polymeric matrix, which increases their resistance to antibiotics the host immune system. During growth, bacterial cooperate through specific quorum-sensing (QS) signals. Taking advantage this mechanism formation, we hypothesized that interrupting communication among bacteria simultaneously degrading matrix would inhibit growth. To end, coatings...
Abstract The emergence of antibiotic‐resistant bacteria and the failure existing antibacterial therapeutics call for development novel treatment strategies. Furthermore, formation bacterial biofilms restricts drug penetration efficiency, causing life‐threatening infections. Bacterial attachment biofilm are regulated by cell‐to‐cell communication phenomenon called quorum sensing (QS). In this work, antimicrobial silver nanoparticles (AgNPs) decorated in a layer‐by‐layer fashion with...
Pseudomonas aeruginosa bacteria originate severe infections in hospitalized patients and those with chronic debilitating diseases leading to increased morbidity mortality, longer hospitalization huge financial burden the healthcare system. The clinical relevance of P. is by capability this bacterium grow biofilms develop multidrug resistant mechanisms that preclude conventional antibiotic treatments. Herein, we engineered novel multimodal nanocomposites integrate same entity antimicrobial...
Bacteria-mediated diseases are a global healthcare concern due to the development and spread of antibiotic-resistant strains. Cationic compounds considered membrane active biocidal agents having great potential control bacterial infections, while limiting emergence drug resistance. Herein, versatile simple layer-by-layer (LbL) technique is used coat alternating multilayers an antibacterial aminocellulose conjugate biocompatible hyaluronic acid on polymer nanoparticles (NPs), taking advantage...
Lignin-capped silver nanoparticles were incorporated in situ into polyurethane foams during their polymerization to obtain multifunctional materials suitable for chronic wound dressing. Lignin with increased phenolic content, achieved through the enzymatic grafting of natural compounds, played dual role a reducing agent synthesis lignin-capped and as nanoformulated polyol additive composition able react isocyanate. The nanoparticles-embedded showed over 4 5 logs bacterial growth reduction...
The increased emergence of antibiotic-resistant bacteria is a growing public health concern, and although new drugs are constantly being sought, the pace development slow compared with evolution spread multidrug-resistant species. In this study, we developed novel broad-spectrum antimicrobial agent by simply transforming vancomycin into nanoform using sonochemistry. Vancomycin glycopeptide antibiotic largely used for treatment infections caused Gram-positive but inefficient against...
Contact lenses (CL) provide visual correction but their use may also induce several adverse effects causative of discomfort and conditions that lead to stop or discontinue use. Discomfort is mainly caused by insufficient wetting, impairment the antioxidant defence system eye infections. The current work reports on a single step sonochemical coating CL with ZnO nanoparticles (NPs), chitosan (CS) gallic acid (GA). GA CS are expected improve comfort imparting respectively properties enhanced...
Catheter-associated urinary tract infections (CAUTIs), caused by biofilms, are the most frequent health-care associated infections. Novel antibiofilm coatings needed to increase catheters' life-span, decrease prevalence of CAUTIs and reduce development antimicrobial resistance. Herein, antibacterial zinc oxide nanoparticles (ZnO NPs) were decorated with a biofilm matrix-degrading enzyme amylase (AM) simultaneously deposited onto silicone catheters in one-step sonochemical process. The...
Abstract Urinary catheters expose patients to a high risk of acquiring nosocomial infections. To prevent this infection, cellobiose dehydrogenase (CDH), an antimicrobial enzyme able use various oligosaccharides as electron donors produce hydrogen peroxide using oxygen acceptor, was covalently grafted onto plasma‐activated urinary polydimethylsiloxane (PDMS) catheter surfaces. Successful immobilization CDH on PDMS confirmed by Fourier transformed‐infrared spectrometry and production H 2 O ....
Targeted bactericide nanosystems hold significant promise to improve the efficacy of existing antimicrobials for treatment severe bacterial infections, minimizing side effects and lowering risk development antibiotic resistance. In this work, we developed antibody-functionalized nanocapsules (NCs) containing antibacterial essential oil (EO) selective effective eradication Staphylococcus aureus. Antibacterial EO NCs were produced via self-assembly nanoencapsulation in plant-derived protein...
In healthcare facilities, environmental microbes are responsible for numerous infections leading to patient's health complications and even death. The detection of the pathogens present on contaminated surfaces is crucial, although not always possible with current microbial technologies requiring sample collection transfer laboratory. Based a simple sonochemical coating process, smart hospital fabrics capacity detect live bacteria by change colour presented here. Prussian Blue nanoparticles...
The potential of ionic liquids (ILs) to be used as antimicrobial agents for biomedical applications has been hindered by the fact that most them are cytotoxic toward mammalian cells. Understanding mechanism bacterial and cellular damage ILs is key their safety design. In this work, we evaluate activity mode action several with varying anions cations clinically relevant Gram-negative Escherichia coli. Langmuir monolayer technique was if IL's related cell membrane interaction an effective E....
Multidrug antimicrobial resistance is a constantly growing health care issue associated with increased mortality and morbidity, huge financial burden. Bacteria frequently form biofilm communities responsible for numerous persistent infections resistant to conventional antibiotics. Herein, novel nanoparticles (NPs) loaded the natural bactericide farnesol (FSL NPs) are generated using high-intensity ultrasound. The nanoformulation of improved its antibacterial properties demonstrated complete...
Abstract Recurrent catheter‐associated urinary tract infections (CAUTIs) in catheterized patients, increase their morbidity and hospital stay at substantial costs for healthcare systems. Hence, novel efficient strategies mitigating CAUTIs are needed. In this work, a bio‐based nanocomposite coating is engineered with bactericidal, antibiofilm, antioxidant properties on commercial silicone catheters using combined ultrasound/nanoparticles (NPs) driven approach. This approach integrates...
Hospital fabrics and wound dressings with antibacterial properties are essential to minimize infection risks associated bacterial colonization of textiles. A key challenge these materials lies in the difficulty assessing their functional lifespan. Integrating bacterial-sensing elements into smart textiles enables real-time in-situ evaluation activity. However, this approach is often hindered by reactivity between bactericidal components, limited stability selectivity sensing probes, high...
In this study, freestanding nanobiocomposite films were obtained by the sequential deposition of biopolymer-capped silver nanoparticles (AgNPs) and hyaluronic acid (HA). At first, dispersions AgNPs decorated with chitosan (CS) or aminocellulose (AC) synthesized applying high intensity ultrasound. These polycationic nanoentities layer-by-layer assembled HA polyanion to generate stable 3D supramolecular constructs, where play dual role active agent structural element. SEM images assemblies...
The emergence of antibiotic resistant bacteria coupled with the shortage efficient antibacterials is one most serious unresolved problems for modern medicine. In this study, nano-hybridization clinically relevant antibiotic, gentamicin, bacterial pro-pathological cell-to-cell communication-quenching enzyme, acylase, innovatively employed to increase its antimicrobial efficiency against Pseudomonas aeruginosa planktonic cells and biofilms. sonochemically generated hybrid gentamicin/acylase...
Catheter-associated urinary tract infections (CAUTI) are among the most common bacterial associated with prolonged hospitalization and increased healthcare expenditures. Despite recent advances in prevention treatment of these infections, there still many challenges remaining, them creation a durable catheter coating, which prevents biofilm formation. The current work reports on method protecting medical tubing endowed antibiofilm properties. Silicone catheters coated sonochemically ZnO...