A5049656305- Air Quality and Health Impacts
- Nanoparticles: synthesis and applications
- Energy and Environment Impacts
- Inhalation and Respiratory Drug Delivery
- Vehicle emissions and performance
- Air Quality Monitoring and Forecasting
- Climate Change and Health Impacts
- COVID-19 impact on air quality
- Atmospheric chemistry and aerosols
- Healthcare and Environmental Waste Management
- TiO2 Photocatalysis and Solar Cells
- Advanced Nanomaterials in Catalysis
- Chemistry and Chemical Engineering
- Energy, Environment, and Transportation Policies
- Heavy Metal Exposure and Toxicity
- Recycling and Waste Management Techniques
- Advancements in Transdermal Drug Delivery
- Microplastics and Plastic Pollution
- Graphene and Nanomaterials Applications
- Thermochemical Biomass Conversion Processes
- Occupational and environmental lung diseases
- Heme Oxygenase-1 and Carbon Monoxide
- Polydiacetylene-based materials and applications
- Barrier Structure and Function Studies
- Advanced Glycation End Products research
University of Milano-Bicocca
2015-2024
The production and use of nanomaterials (NMs) has increased over the last decades posing relevant questions on their risk after release exposure population or sub-populations. In this context, safe sustainable by design (SSbD) approach framework requires to assess potential hazard connected with intrinsic properties material along whole life cycle NM and/or nano enabled products. Moreover, in years, new advanced methodologies (NAMs) increasingly gained attention for alternative methods...
In the context of nosocomial infections, there is an urgent need to develop efficient nanomaterials (NMs) with antibacterial properties for prevention infection diseases. Metal oxide nanoparticles (MeO-NPs) are promising candidates development new textiles. However, direct exposure MeO-NPs and MeO-coated NMs through skin contact could constitute a severe hazard human health. this work, toxicity copper zinc (CuO, ZnO) NPs antimicrobial-coated textiles was assessed on in vitro reconstructed 3D...
The green and safe polymer HEC confers bio-interactive properties to Ag-Nps that, together with the small size positive ζ potential, increase their biological reactivity towards zebrafish embryos.
This report demonstrates a case study within the ASINA project, aimed at instantiating roadmap with quantitative metrics for Safe(r) and (more) Sustainable by Design (SSbD) options. We begin description of ASINA's methodology across product lifecycle, outlining elements within: Physical-Chemical Features (PCFs), Key Decision Factors (KDFs), Performance Indicators (KPIs). Subsequently, we delve in proposed decision support tool implementing SSbD objectives various dimensions—functionality,...
The diffusion of e-cigarette (e-CIG) opens a great scientific and regulatory debate about its safety. huge number commercialized devices, e-liquids with almost infinite chemical formulations the growing market demand for rapid efficient toxicity screen system that is able to test all these references related aerosols. A consensus on best protocols e-CIG safety assessment still far be achieved, since variables characterizing products (e.g., flavoring type concentration, nicotine device,...
Emissions from diesel vehicles and biomass burning are the principal sources of primary ultrafine particles (UFP). The exposure to UFP has been associated cardiovascular pulmonary diseases, including lung cancer. Although many aspects toxicology ambient particulate matter (PM) have unraveled, molecular mechanisms activated in human cells by still poorly understood. Here, we present an RNA-seq time-course experiment (five time point after single dose exposure) used investigate differential...
Microplastics (MPs) represent a worldwide emerging relevant concern toward human and environmental health due to their intentional or unintentional release. Human exposure MPs by inhalation is predicted be among the most hazardous. include both engineered, primary MPs, secondary materials obtained fragmentation from any plastic good. The major part of constituted second ones that are irregular in size, shape composition. These features make study biological impact heterogenous extremely high...
<ns4:p>Background Reworking and use of nanocomposites (materials with incorporated or embedded nanomaterials) are shown to release relevant quantities particles that can cause risk for the workers product users. It is mandatory provide Conditions Use (CoU) in Exposure Scenarios REACH legislation. This requires information on emissions registrant required report. Regardless legislation, rarely studied reported. Here, we revised available emission/release studies considering mechanical...
Biomass burning (BB) represents a global concern due to its impact on air pollution, health and climate change, resulting in 2.3 million premature deaths yearly. BB the residential sector is one of main sources primary Particulate Matter emissions. emits significant amount black brown carbon, Polycyclic Aromatic Hydrocarbons, contributes secondary formation ozone by photochemical reaction volatile organic compounds nitrogen oxides. On other side, green renewable alternative source fossil...
<ns3:p>Background Reworking and use of nanocomposites (materials with incorporated or embedded nanomaterials) are shown to release relevant quantities particles that can cause risk for the workers product users. It is mandatory provide Conditions Use (CoU) in Exposure Scenarios REACH legislation. This requires information on emissions registrant required report. Regardless legislation, rarely studied reported. Here, we revised available emission/release studies considering mechanical...
Bio-based nanomaterials (B-NMs), such as silica oxide (SiO2)- and lignin (Lig)- based nanoparticles (NPs) derived from biomass waste, have gained attention in the last few years view of promoting sustainability principles several applications. However, scarce data are available about their safety. Thus, a hazard-testing strategy was designed considering reference safe-and-sustainable-by-design (SSbD) framework for chemicals materials, prioritizing use new approach methodologies (NAMs), vitro...
Silver nanoparticles (Ag NPs) are among the most widely used metal-based nanomaterials (NMs) and their applications in different products, also as antibacterial additives, increasing. In present manuscript, according to an adverse outcome pathway (AOP) approach, we tested two safe-by-design (SbD) newly developed Ag NPs coated with hydroxyethyl cellulose (HEC), namely AgHEC powder solution. These novel were compared reference (naked polyvinylpyrrolidone-PVP). Cell viability, inflammatory...
Particulate matter (PM) exposure is related to pulmonary and cardiovascular diseases, with increased inflammatory status. The release of the proinflammatory interleukin- (IL-) 1β, controlled by a dual pathway, formation inactive pro-IL-1β, through Toll-like receptors (TLRs) activation, its cleavage NLRP3 inflammasome. THP-1-derived macrophages were exposed for 6 h 2.5 μg/cm(2) Milan PM10, potential promote IL-1β binding TLRs activating has been examined. Summer induced marked response in...
Summary This study aims to critically evaluate the effect of photochemical smog on COPD patients in Nigeria. A cohort was recruited from two large hospitals Abuja Symptom questionnaires, daily diaries, dyspnoea scale and measurement lung function were used obtain health data. Real-time air pollution data obtained a monitoring site at airport. Measured concentrations, for precursors smog, are far higher than those recorded developed world where link between respiratory has been observed....
The enormous technological relevance of titanium dioxide (TiO2) nanoparticles (NPs) and the consequent concerns regarding potentially hazardous effects that exposure during production, use, disposal can generate, encourage material scientists to develop validate intrinsically safe design solution (safe-by-design). Under this perspective, encapsulation in a silica (SiO2) matrix could be an effective strategy improve TiO2 NPs safety, preserving photocatalytic antibacterial properties. In work,...
The current European (EU) policies, that is, the Green Deal, envisage safe and sustainable practices for chemicals, which include nanoforms (NFs), at earliest stages of innovation. A theoretically by design (SSbD) framework has been established from EU collaborative efforts toward definition quantitative criteria in each SSbD dimension, namely, human environmental safety dimension environmental, social, economic sustainability dimensions. In this study, we target demonstrate journey...
The widespread use of silver nanoparticles (Ag NPs) in food and consumer products suggests the relevance human oral exposure to these nanomaterials (NMs) raises possibility adverse effects gastrointestinal tract. aim this study was investigate toxicity Ag NPs a intestinal cell line, either uncoated or coated with polyvinylpyrrolidone PVP) hydroxyethylcellulose HEC) digested simulated fluids. Physicochemical transformations during different stages vitro digestion were identified prior...
Catheter-associated urinary tract infections (CAUTI) are among the most common bacterial associated with prolonged hospitalization and increased healthcare expenditures. Despite recent advances in prevention treatment of these infections, there still many challenges remaining, them creation a durable catheter coating, which prevents biofilm formation. The current work reports on method protecting medical tubing endowed antibiofilm properties. Silicone catheters coated sonochemically ZnO...
Exposure to engineered nanoparticles (NPs) and ambient particles (PM) has increased significantly. During the last decades application of nano-objects daily-life goods emissions produced in highly urbanized cities have considerably augmented. As a consequence, understanding possible effects NPs PM on human respiratory system particularly air-blood barrier (ABB) become primary interest. The crosstalk between lung epithelial cells underlying endothelial is indeed essential determining inhaled...