A5075310472- Environmental Toxicology and Ecotoxicology
- Nanoparticles: synthesis and applications
- Toxic Organic Pollutants Impact
- Carcinogens and Genotoxicity Assessment
- Air Quality and Health Impacts
- Reproductive Biology and Fertility
- Sperm and Testicular Function
- Effects and risks of endocrine disrupting chemicals
- Energy and Environment Impacts
- Graphene and Nanomaterials Applications
- Pesticide Exposure and Toxicity
- Animal Ecology and Behavior Studies
- Pesticide and Herbicide Environmental Studies
- Drug Transport and Resistance Mechanisms
- COVID-19 impact on air quality
- Microplastics and Plastic Pollution
- DNA and Nucleic Acid Chemistry
- Pharmaceutical and Antibiotic Environmental Impacts
- Cannabis and Cannabinoid Research
- TiO2 Photocatalysis and Solar Cells
- Anesthesia and Neurotoxicity Research
- Building materials and conservation
- Physiological and biochemical adaptations
- Invertebrate Immune Response Mechanisms
- Insect and Pesticide Research
University of Milano-Bicocca
2015-2025
Istituto Ortopedico Gaetano Pini
2024
Bar-Ilan University
2015
Mylan (Switzerland)
2015
Milano University Press
2015
Museum Conservation Institute
2014
University of Milan
1989-2009
University of Rome Tor Vergata
1996-1998
University of Perugia
1989
Microplastic pollution represents a global problem with negative impacts on aquatic environment and organisms' health. To date, most of the laboratory toxicological studies microplastics (MPs) have made use single commercial micro nano-polymers, which do not reflect heterogeneity environmental MPs. improve relevance hazard assessment, micrometer-sized plastic particles miscellaneous non-reusable waste plastics, size <100 µm <50 (waste microplastics, wMPs), were characterized by microscopic...
The green and safe polymer HEC confers bio-interactive properties to Ag-Nps that, together with the small size positive ζ potential, increase their biological reactivity towards zebrafish embryos.
We have previously shown that the endogenous lipid palmitoylethanolamide (PEA) induced relief of neuropathic pain through an action upon receptors located on nociceptive pathway. Recently, it has been proposed immune cells, in particular mast and microglia, by releasing algogen mediators interact with neurons to alter sensitivity thereby contributing development maintenance chronic states. The aim this work was explore whether anti-nociceptive properties PEA might be accompanied modulation...
COVID-19 pandemic had a significant impact on global public health. The spread of the disease was related to high transmissibility SARS-CoV-2 virus but incidence and mortality rate suggested possible relationship with environmental factors. Air pollution has been hypothesized play role in transmission resulting severity disease. Here we report plausible vitro toxicological mode action by which fine particulate matter (PM2.5) could promote higher infection PM2.5 promotes 1.5 fold...
Nanomaterials (NMs), including nanoparticles (NPs), offer promising potential in achieving the European Commission's Green Deal goals of climate-neutral, zero-pollution and circular economy. Metal oxide NPs display antimicrobial properties, with efficacy also towards antimicrobial-resistant bacteria. Nevertheless, increasing manufacture, use unintended release NMs particularly aquatic compartments, raises concerns about their environmental sustainability safety non-target organisms. Within...
A nanocomposite coating based on TiO<sub>2</sub>nanoparticles and poly(2-ethyl-2-oxazoline) is used as consolidant of matte paintings (such temperas), by exploiting bulk scattering phenomenon to mimic the surface diffusive properties painted surface.
The increased resistances to conventional antibiotics determine a strong need for new antibacterials, and specific syntheses at the nanoscale promise be helpful in this field. A novel Zinc-doped Copper oxide nanocomposite (nZn-CuO) has been recently sonochemically synthesized successfully tested also against multi-drug resistant bacteria. After synthesis characterization of physicochemical properties, nZn-CuO is here evaluated by Frog Embyo Teratogenesis Assay-Xenopus test its toxicological...
The growing global production of zinc oxide nanoparticles (ZnONPs) suggests a realistic increase in the environmental exposure to such nanomaterial, making knowledge its biological reactivity and safe-by-design synthesis mandatory. In this study, embryotoxicity ZnONPs (1–100 mg/L) specifically synthesized for industrial purposes with different sizes, shapes (round, rod) surface coatings (PEG, PVP) was tested using frog embryo teratogenesis assay-Xenopus (FETAX) identify potential target...
Greater Cairo (Egypt) is a megalopolis where the studies of air pollution events are extremely high relevance, for geographical-climatological aspects, anthropogenic emissions and health impact. While preliminary on particulate matter (PM) chemical composition in have been performed, no data yet available PM's toxicity. In this work, vitro toxicity fine PM (PM2.5) sampled an urban area during 2017-2018 was studied. The PM2.5 samples collected spring, summer, autumn winter were characterized...
The antibacterial activity of metal oxide (MeO) nanoparticles (NPs) has been extensively reported. Nevertheless, there is a general concern about MeO NPs toxicity, and much efforts are being devoted to improve safe employment these nanomaterials by surface functionalization. In this work, we propose investigate if the coating copper zinc oxides (CuO ZnO) with polymers poly(ethylene imine) (PEI) or glycol) (PEG) able protect non-target cells organisms from toxicity MeOs NPs. overall results...
Iron nanoparticles (NPs) have been proposed as a tool in very different fields such environmental remediation and biomedical applications, including food fortification against iron deficiency, even if there is still concern about their safety. Here, we propose Xenopus laevis embryos suitable model to investigate the toxicity bio-interactions at intestinal barrier of Fe3O4 zerovalent (ZVI) NPs compared Fe(II) (III) salts 5 100 mg Fe/L concentration range using Frog Embryo Teratogenesis Assay...
We previously demonstrated that the intraperitoneal administration of palmitoylethanolamide (PEA) in mice with chronic constriction injury sciatic nerve evoked a relief both thermal hyperalgesia and mechanical allodynia neuropathic mice. Since diabetic neuropathy is one most common long-term complications diabetes, we explored ability PEA to also this kind pain, employing well established streptozotocin-induced animal model type 1 diabetes. Our findings relieves allodynia, counteracts growth...
Silver nanoparticles (AgNPs) are among the most exploited antimicrobial agents and used in many consumer products. Size surface reactivity critical physico-chemical properties responsible for NPs toxicity, coatings, often to functionalize or stabilize AgNPs, can influence their toxic profile biocompatibility. In current study developmental toxicity of (1) negatively charged citrate-coated AgNPs (Cit-AgNPs), (2) positively branched polyethylenimine-coated (BPEI-AgNPs), (3) Ag+ (from 0.0625...