A5086104389- Microtubule and mitosis dynamics
- Monoclonal and Polyclonal Antibodies Research
- Genetics, Bioinformatics, and Biomedical Research
- Cancer-related gene regulation
- Signaling Pathways in Disease
- T-cell and B-cell Immunology
- Cellular transport and secretion
- Protease and Inhibitor Mechanisms
- Congenital heart defects research
- Multiple Myeloma Research and Treatments
- Innovative Teaching Methods
- Neurogenesis and neuroplasticity mechanisms
- Developmental Biology and Gene Regulation
- Cancer Cells and Metastasis
- Glycosylation and Glycoproteins Research
- Hearing Impairment and Communication
- CAR-T cell therapy research
- Biomedical and Engineering Education
- Moyamoya disease diagnosis and treatment
- TGF-β signaling in diseases
- Peptidase Inhibition and Analysis
- Chromatin Remodeling and Cancer
- Protein Structure and Dynamics
- Galectins and Cancer Biology
- Hand Gesture Recognition Systems
West Virginia University
2013-2022
Rensselaer Polytechnic Institute
2019-2021
The University of Texas at Austin
2008-2021
Troy University
2020
Abstract Helper and cytotoxic T cells accomplish focused secretion through the movement of vesicles toward microtubule organizing center (MTOC) translocation MTOC to target contact site. In this study, using Jurkat OT-I TCR transgenic primary murine CTLs, we show that dynein-binding proteins nuclear distribution E homolog 1 (NDE1) dynactin (as represented by p150Glued) form mutually exclusive complexes with dynein, exhibit nonoverlapping distributions in target-stimulated cells, mediate...
During vertebrate gastrulation, canonical Wnt signaling induces the formation of neural plate border (NPB). is also thought to be required for subsequent specification crest (NC) lineage at NPB, but direct evidence lacking. We found previously that disintegrin metalloproteinase ADAM13 activation and NC induction in Xenopus Here, we report knockdown or its close paralog ADAM19 severely downregulates activity inhibiting without affecting earlier NPB formation. Surprisingly, functions...
Abstract Malignant glioma is a formidable disease that commonly leads to death, mainly due the invasion of tumor cells into neighboring tissues. Therefore, inhibition cell may provide an effective therapy for malignant glioma. Here we report nicotinic acid (NA), essential vitamin, inhibits in vitro and vivo . Treatment U251 with NA results reduced invasion, which accompanied by loss mesenchymal phenotype increase cell-cell adhesion. At molecular level, transcription adherens junction protein...
Ephrin-B signaling has been implicated in many normal and pathological processes, including neural crest development tumor metastasis. We showed previously that proteolysis of ephrin-B ligands by the disintegrin metalloprotease ADAM13 is necessary for canonical Wnt signal activation induction Xenopus, but it was unclear if these mechanisms are conserved mammals. Here, we report mammalian ADAM9 cleaves ephrin-B1 ephrin-B2 can substitute Xenopus to induce crest. found expression elevated human...
Abstract Readily available, free, computational approaches, adaptable for topics accessible first to senior year classes and individual research projects, emphasizing contributions of noncovalent interactions structure, binding catalysis were used teach Course‐based Undergraduate Research Experiences that fulfil generally accepted main CURE components: Scientific Background, Hypothesis Development, Proposal, Experiments, Teamwork, Data Analysis quantitative data, Conclusions, Presentation.
Several diseases originate via dysregulation of the actin cytoskeleton. The ARID3A/Bright transcription factor has also been implicated in malignancies, primarily those derived from hematopoietic lineages. Previously, we demonstrated that ARID3A shuttles between nucleus and plasma membrane, where it localizes within lipid rafts. There interacts with components B-cell receptor (BCR) to reduce its ability transmit downstream signaling. We demonstrate here a direct component ARID3A-regulated...
Abstract Dramatic cytoskeletal activities and protein movements are seen when T cells engage cognate targets or antigen presenting cells. These include formation of a specialized contact site known as the immunological synapse (IS), clustering vesicles around microtubule organizing center (MTOC) translocation MTOC up to IS. Ultimately, this leads focused secretion towards target. In an effort understand how takes place, we have investigated roles dynein, p150Glued, Lis1,NDE1 NDEL1 using...
Extended abstract of a paper presented at Microscopy and Microanalysis 2010 in Portland, Oregon, USA, August 1 – 5, 2010.
Course‐based Undergraduate Research Experiences (CUREs) are an effective approach to integrating a research experience into the teaching laboratory enhance student learning gains. Expanding availability of CUREs provides greater access this high‐impact practice and can create community for mentored undergraduate research. We preparing resources support adoption as part Malate Dehydrogenase CURE Community (MCC), NSF‐funded project collaborative faculty at all higher education institution...
ABSTRACT Previously we demonstrated that the ARID3A transcription factor shuttles between nucleus and plasma membrane, where it localizes within lipid rafts. There interacts with components of B Cell Receptor (BCR) to reduce its ability transmit downstream signaling. We demonstrate in this report a direct component ARID3A-regulated BCR signal strength is cortical Actin. Actin exclusively rafts via binding protein EZRIN, which confines unstimulated BCRs ligation discharges ARID3A-EZRIN...