A5048446948- Cardiovascular Function and Risk Factors
- Cardiovascular Disease and Adiposity
- Blood Pressure and Hypertension Studies
- Cardiovascular Health and Disease Prevention
- Heart Failure Treatment and Management
- Genetic Associations and Epidemiology
- Cardiovascular Health and Risk Factors
- Coronary Interventions and Diagnostics
- Antiplatelet Therapy and Cardiovascular Diseases
- Nutritional Studies and Diet
- Hormonal Regulation and Hypertension
- Heart Rate Variability and Autonomic Control
- Atrial Fibrillation Management and Outcomes
- Health Promotion and Cardiovascular Prevention
- Cardiovascular and exercise physiology
- Cardiac Valve Diseases and Treatments
- Cardiac and Coronary Surgery Techniques
- Nutrition, Genetics, and Disease
- Eicosanoids and Hypertension Pharmacology
- Aortic Disease and Treatment Approaches
- Cardiac Imaging and Diagnostics
- Cardiac Fibrosis and Remodeling
- Cardiac electrophysiology and arrhythmias
- Healthcare Systems and Public Health
- Fatty Acid Research and Health
University of Lübeck
2005-2016
Universitätsmedizin Greifswald
2013-2015
German Centre for Cardiovascular Research
2013-2015
Kiel University
2002-2015
University of Regensburg
2015
Asklepios
2013-2015
University Hospital Schleswig-Holstein
2005-2013
University Medical Center
2008
University Hospital and Clinics
2008
More accurate coronary heart disease (CHD) prediction, specifically in middle-aged men, is needed to reduce the burden of more effectively. We hypothesised that a multilocus genetic risk score could refine CHD prediction beyond classic scores and obtain precise estimates using prospective cohort design.Using data from nine European cohorts, including 26,221 we selected case-cohort setting 4,818 healthy men at baseline, used Cox proportional hazards models examine associations between based...
Degenerative aortic valve disease (DAVD), a common finding in the elderly, is associated with an increased risk of death due to cardiovascular causes. Taking advantage its longitudinal design, this study evaluates prevalence DAVD and temporal associations long-term exposure factors general population. We studied 953 subjects (aged 25–74 years) from random sample German residents. Risk had been determined at baseline investigation 1994/95. At follow-up investigation, 10 years later,...
We aimed to analyze the association between hepatic steatosis and aortic valve sclerosis in general population.Cross-sectional data of 2212 men women, aged 45 81 years, from baseline examination population-based Study Health Pomerania (SHIP-0) were analyzed. Hepatic was primarily defined as presence a hyperechogenic ultrasound pattern liver. Aortic determined by echocardiography. In our sample, present 877 (39.7%) individuals. Among participants with steatosis, more common (n=323; 36.8%)...
Background. Even mild renal dysfunction is a predictor of cardiovascular morbidity. We investigated whether sub-threshold microalbuminuria or mildly decreased estimated glomerular filtration rate (eGFR) are related to left ventricular hypertrophy (LVH) in the general population.
It is unclear whether persistent prehypertension causes structural or functional alterations of the heart.We examined echocardiographic data 1005 adults from a population-based survey at baseline in 1994/1995 and follow-up 2004/2005. We compared individuals who had either persistently normal (<120 mmHg systolic <80 diastolic, n = 142) prehypertensive blood pressure (120-139 80-89 mmHg, 119) both examinations using multivariate regression modeling.Over 10 years, left ventricular end-diastolic...
Background Extreme alterations in blood count such as anaemia or polycythemia are known to cause circulatory changes and, if these persist, adaptations of cardiac geometry. Objectives To investigate further the association between haematocrit levels and left ventricular geometry a population-based sample. Methods We examined 687 women 648 men, aged 25–74 years, participating third MONICA Augsburg study. Anthropometry, pressure, laboratory measurements M-mode echocardiography were obtained...
In developed countries, sclerotic and calcific degeneration of the aortic valve is a common disorder showing pathophysiologic similarities with atherothrombotic coronary disease. Light to moderate alcohol consumption has been associated lower risk for disease mortality. Whether affects development sclerosis (AVS) not well known. present study, we aim analyze cross-sectional association between average daily AVS in general population.We analyzed data from 2022 men women, aged 45 81 years,...
Idiotype (Id) vaccination provides an interesting immunotherapeutic strategy against B-cell lymphomas. In multiple myeloma (MM), however, the therapeutic efficacy of Id has been disappointing. attempt to improve antitumoral potential, we added granulocyte-macrophage colony stimulating factor (GM-CSF) and interleukin 2 (IL-2) protocol. Balb/c mice were inoculated i.p. (d 2) with different doses (1-5 x 10(5)) HOPC cells secreting Ig(HOPC) protein. Two days later, animals injected 10,000 U...
BackgroundThere are considerable regional disparities in the prevalence of cardiovascular risk factors within Germany. We undertook this study to investigate differences left ventricular hypertrophy (LVH) between northeast and southwest
Abstract OBJECTIVES In this post hoc analysis of the Ticagrelor in coronary artery bypass grafting (CABG) trial, we aimed to analyse patients treated with CABG receiving either complete revascularization (CR) or incomplete (ICR) independent from random allocation ticagrelor aspirin. METHODS Of 1859 enrolled 1550 (83.4%) received CR and 309 (16.6%) ICR. Outcomes were evaluated regarding all-cause mortality, cardiovascular death, myocardial infarction (MI), repeat revascularization, stroke...
We evaluated the effect of ticagrelor monotherapy on outcomes after multiple arterial grafting (MAG) or single (SAG) in coronary artery bypass (CABG).In a post hoc, non-randomized analysis TiCAB (Ticagrelor CABG; ClinicalTrials.gov NCT01755520) trial, we compared event rates for versus aspirin patients undergoing MAG and SAG. Primary outcome was composite cardiovascular death, non-fatal myocardial infarction (MI), stroke repeat revascularization 1 year CABG. Secondary included individual...