A5036988007- Endodontics and Root Canal Treatments
- Periodontal Regeneration and Treatments
- Bone Tissue Engineering Materials
- Dental materials and restorations
- Mesenchymal stem cell research
- Dental Radiography and Imaging
- Electrospun Nanofibers in Biomedical Applications
- Tissue Engineering and Regenerative Medicine
- Dental Implant Techniques and Outcomes
- Dental Trauma and Treatments
- Laser Applications in Dentistry and Medicine
- Dental Anxiety and Anesthesia Techniques
- dental development and anomalies
- Cell Adhesion Molecules Research
- Oral microbiology and periodontitis research
- Orthopaedic implants and arthroplasty
- Proteoglycans and glycosaminoglycans research
- Reconstructive Surgery and Microvascular Techniques
- Drilling and Well Engineering
- Corneal Surgery and Treatments
- Graphene and Nanomaterials Applications
- Dental Research and COVID-19
- Dental Erosion and Treatment
- Surgical Sutures and Adhesives
- Peptidase Inhibition and Analysis
Alexandria University
2016-2025
Mansoura University
2023
University of Genoa
2011-2017
Ospedale Policlinico San Martino
2012-2017
Cairo University
2012
Alleanza Contro il Cancro
2010
Umbilical cord mesenchymal stem cells (UC-MSCs) show properties similar to bone marrow (BM-MSCs), although controversial data exist regarding their osteogenic potential. We prepared clinical-grade UC-MSCs from Wharton's Jelly and we investigated if could be used as substitutes for BM-MSCs in muscoloskeletal regeneration a more readily available functional source of MSCs. were loaded onto scaffolds implanted subcutaneously (ectopically) critical-sized calvarial defects (orthotopically) mice....
Abstract With the expanding knowledge of tooth regeneration and biological mechanisms functional dental tissue repair, current treatment strategies are beginning to give way evolving fields such as engineering biomimetics. Dental pulp stem cells were isolated from rabbit teeth seeded onto scaffolds prepared 50/50 poly(lactic‐co‐glycolic acid) polymers using two different porogen particle sizes. These cell/scaffold constructs then transplanted subcutaneously in rabbits. The expanded showed...
Platelet lysates (PL), which are derived from platelets, cocktails of growth factors and cytokines that can promote tissue regeneration. Until today, most studies have focused on factor content platelets rather than their potential as a reservoir mediators cytokines. Taking advantage an in vitro scratch assay performed under both normal inflammatory conditions, the present work, we report at physiologic concentrations, PL enhanced wound closure rates NCTC 2544 human keratinocytes. This...
The periosteum plays a pivotal role during bone development and repair contributing to vascularization osteoprogenitor cells source. We propose periosteal substitute engineered using platelet-rich plasma (PRP) membrane incorporating autologous marrow-derived mesenchymal stem (PRP/BMSC gel membrane) be wrapped around an osteoconductive scaffold for regeneration of compromised defects. PRP/BMSC was optimized different compositions optimal release vascular endothelial growth factor (VEGF)...
The purpose of this study was to compare the penetration methylene blue (MB) dye after laser irradiation using PIPS (photon-induced photoacoustic streaming) and SWEEPS (shockwave enhanced emission methods compared Passive ultrasonic irrigation (PUI) their effect on dentin microhardness. A total 44 single-rooted human teeth which were extracted for orthodontic or periodontal reasons used. decapitated standardize roots 12 mm in length. Canals prepared up size #30.6% divided randomly into four...
Abstract Introduction Eradication of residual biofilm from root canal dentine is critical for the success regenerative endodontic procedures (REPs). The aim study To evaluate influence ultrasonically activated irrigants in concentrations used REPs removal dual-species three-dimensionally printed tooth models with attached samples. Methodology Seventy-two teeth were fabricated a standardized slot apical third to ensure precise fit human specimen. Dual-species biofilms (comprising Enterococcus...
Tissue engineering in the head and neck area, presents numerous advantages. One of most remarkable advantages is that regeneration only a small amount tissue can be highly beneficial to patient, particularly field periodontal regeneration. For decades, successful osseointegration has provided thousands restorations maintain normal function. With increasing need utilize dental implants for growing patients enhance their function simulate tooth physiology proprioception, there appears an...
This study was designed as a split-mouth randomized controlled clinical trial to evaluate the effects of novel bioactive glass scaffold-tailored amorphous multiporous (TAMP)-for preservation alveolar bone following tooth extraction in class II orthodontic patients. TAMP scaffolds were prepared and sterilized. Patients screened for eligibility, 6 patients accounting 14 sockets included this stage. Sockets randomly allocated either control (left empty) or test (grafted with scaffold...
Bioactive glass (BG) occupies a significant position in the field of hard and soft tissue regeneration. Different processing techniques formulas have been introduced to expand their regenerative, angiogenic, antibacterial properties. In present study, new formula bborosilicate bioactive nanofibers was prepared tested for its wound-healing efficacy rabbit animal model. The ((1-2) mol% B2O3 (68-69) SiO2, (29-30) CaO) primarily by sol-gel technique followed electrospinning technique. material...
INTRODUCTION: Different irrigations solutions may cause alteration in the physicochemical properties of dentin structure thereby affecting microhardness root canal dentin. OBJECTIVES: to evaluate effect different irrigation protocols on human MATERIALS AND METHODS: Forty extracted single rooted lower premolars were used. All teeth instrumented using manual stainless steel files and irrigated by 2ml distilled water between each file, then sectioned longitudinal splitting tooth. The halves...
INTRODUCTION: Revascularization procedures have been limited to immature teeth but application mature should be clinically investigated as an alternative conventional root canal treatment. The translation of regenerative endodontic into treating is challenging and depends on efficient disinfection, proper size the apical foramen, availability delivery stem cells system. OBJECTIVES: Evaluation revascularization in after enlargement foramen 35 K-file. MATERIALS AND METHODS: Three necrotic...
Aim: To evaluate the antibacterial efficacy of double antibiotic paste (DAP), silver nanoparticle (AgNP) gel, and tailored amorphous multiporous bioactive glass (TAMP-BG) in concentrations suitable for regenerative endodontics (RE) against 3-week-old Enterococcus faecalis biofilms after 24 hours 7 days. Results: Radicular human dentin specimens were prepared inoculated with E. to form biofilms. DAP (1 mg/mL), AgNPs 0.02%, TAMP-BG 100 mg/mL, methylcellulose gel formulations, used as...
Abstract Background Regenerative endodontic procedures (REPs) offer the promise of restoring vitality and function to a previously necrotic infected tooth. However, nature regenerated tissues following REPs remains unpredictable uncontrollable. Decellularized extracellular matrix scaffolds have gained recent attention as for regenerative endodontics. Objectives Preparation characterization bovine dental pulp-derived (P-ECM) hydrogel applications. Biocompatibility capacity prepared scaffold...