A5031949418- Forensic and Genetic Research
- Gout, Hyperuricemia, Uric Acid
- Archaeology and ancient environmental studies
- Pacific and Southeast Asian Studies
- Forensic Anthropology and Bioarchaeology Studies
- Genetic diversity and population structure
- Inflammasome and immune disorders
- Diet and metabolism studies
- Alcohol Consumption and Health Effects
- Urological Disorders and Treatments
- Identification and Quantification in Food
- Rangeland Management and Livestock Ecology
- Archaeology and Historical Studies
- Pleistocene-Era Hominins and Archaeology
- Genetic and phenotypic traits in livestock
- Indigenous Studies and Ecology
- Archaeology and Rock Art Studies
- Wildlife Ecology and Conservation
- Case Reports on Hematomas
- Genomics and Phylogenetic Studies
- Animal Diversity and Health Studies
- Nutritional Studies and Diet
- Classical Antiquity Studies
- Travel-related health issues
- Cardiovascular Health and Risk Factors
University of Otago
2016-2025
University of Chicago
2017-2022
Allan Wilson Centre
2013-2016
Abstract Present-day Tibetans have adapted both genetically and culturally to the high altitude environment of Tibetan Plateau, but fundamental questions about their origins remain unanswered. Recent archaeological genetic research suggests presence an early population on Plateau within past 40 thousand years, followed by arrival subsequent groups 10 years. Here, we obtain new genome-wide data for 33 ancient individuals from elevation sites southern fringe in Nepal, who show are most closely...
Gout, the most common inflammatory arthritis disease, and hyperuricaemia onset are influenced by environmental genetic factors. We sought to investigate these factors in an Indigenous community Guam. In this feasibility study, University of Guam led qualitative inquiry with native community, training (pre-screening participants, data collection methods, biospecimen handling), study implementation (outreach recruitment, collection, DNA extraction quantification), epidemiologic analyses....
High serum urate is a prerequisite for gout and associated with metabolic disease. Genome-wide association studies (GWAS) have reported dozens of loci control; however, there has been little progress in understanding the molecular basis loci. Here, we employed trans-ancestral meta-analysis using data from European East Asian populations to identify 10 new levels. colocalization cis-expression quantitative trait (eQTL) identified further five candidate By cis- trans-eQTL analysis, 34 20...
The Phoenicians emerged in the Northern Levant around 1800 BCE and by 9th century had spread their culture across Mediterranean Basin, establishing trading posts, settlements various European North African locations. Despite widespread influence, what is known of comes from was written about them Greeks Egyptians. In this study, we investigate extent Phoenician integration with Sardinian communities they settled. We present 14 new ancient mitogenome sequences pre-Phoenician (~1800 BCE)...
Archaeological evidence suggests that dogs were introduced to the islands of Oceania via Island Southeast Asia around 3,300 years ago, and reached eastern Polynesia by fourteenth century AD. This dispersal is intimately tied human expansion, but involvement in Pacific migrations not well understood. Our analyses seven new complete ancient mitogenomes five partial mtDNA sequences from archaeological dog specimens Mainland at least three events into region, addition introduction dingoes...
Objective Mitochondria have an important role in the induction of NLRP3 inflammasome response central gout. The objective was to test whether mitochondrial genetic variation and copy number New Zealand Māori Pacific (Polynesian) people Aotearoa associate with susceptibility Methods 437 whole genomes from (predominantly men) (327 gout, 110 without gout) were sequenced. Mitochondrial DNA determined by assessing relative read depth using data produced genome sequencing (32 cases, 43 controls)...
Domesticated cattle were commonplace in northern Africa by about 7,000 years ago. Archaeological evidence, however, suggests they not established southern until much later, no earlier than 2,000 Genetic reconstructions have started to shed light on the movement of African cattle, but efforts been frustrated a lack data south Ethiopia and nature mitochondrial haplogroup T1 which is almost fixed across continent. We sequenced 35 complete genomes from South herd Nguni breed historically...
Abstract Ibiza was permanently settled around the 7 th century BCE by founders arriving from west Phoenicia. The founding population grew significantly and reached its height during 4 BCE. We obtained nine complete mitochondrial genomes skeletal remains two Punic necropoli in a Bronze Age site Formentara. also low coverage (0.47X average depth) of genome one individual, directly dated to 361–178 cal BCE, Cas Molí on Ibiza. analysed compared ancient DNA results with 18 new modern Ibizans...
While Phoenician culture and trade networks had a significant impact on Western civilizations, we know little about the Phoenicians themselves. In 1994, Punic burial crypt was discovered Byrsa Hill, near entry to National Museum of Carthage in Tunisia. Inside this were remains young man along with range goods, all dating late 6th century BCE. Here describe complete mitochondrial genome recovered from Young Man identify that he carried rare European haplogroup, likely linking his maternal...
Large numbers of domestic stock have been reported among the faunal remains recovered from archaeological sites with predominantly forager-associated material culture in highlands Lesotho. These remains, conjunction presence artefacts apparent agropastoralist origin, led to suggestion that either a process neolithisation saw adoption livestock-keeping by traditionally foraging peoples, or extensive contact and trade occurred between groups mountains distant communities. We present here...
The inverted triangle shape of South America places Argentina territory as a geographical crossroads between the two principal peopling streams that followed either Pacific or Atlantic coasts, which could have then merged in Central (CA). Although genetic diversity from this region is therefore crucial to decipher past population movements America, its characterization has been overlooked so far. We report 92 modern and 22 ancient mitogenomes spanning temporal range 5000 years, were compared...
Biological anthropological research, the study of both modern and past humans, is a burgeoning field in Indo-Pacific region. It becoming increasingly apparent that unique environments have resulted an archaeological record does not necessarily align with those northern hemisphere. New, regionally-specific models are being developed, biological research has important role to play establishing human experience within these models. In Indo-Pacific, using ancient tissues adding insight into...
We investigated the genetic diversity and historic relationships among southern African sheep as well between them outside continent by sourcing both archaeological modern samples. Archaeological samples derived from site Die Kelders 1, near Cape Town, date to approximately 1500 years ago. The were taken ear snips Damara, Namaqua Afrikaner, Ronderib Afrikaner on a farm in Prieska Northern Cape. Illumina sequencing libraries constructed for ancient specimens. Ancient specimens enriched...
Domestic pigs (Sus scrofa) were first transported to Polynesia through a series of long-distance voyages ultimately linked the Neolithic expansion Austronesian-speaking people out Asia. The descendants founding belong rare mtDNA group referred as "Pacific Clade" that may have originated in peninsular or island Southeast We report whole genome from domestic any remote islands Pacific. In this brief report, we describe close link discovered between ancient archaeological specimens across and...
Abstract Serum urate is the end-product of purine metabolism. Elevated serum causal gout and a predictor renal disease, cardiovascular disease other metabolic conditions. Genome-wide association studies (GWAS) have reported dozens loci associated with control, however there has been little progress in understanding molecular basis loci. Here we employed trans-ancestral meta-analysis using data from European East Asian populations to identify ten new for levels. colocalization cis -expression...
Establishing robust temporal control of the arrival domesticated stock and associated husbandry skills lifeways in Southern Africa remains frustrated by osteological similarities between domestic wild endemic fauna. We report results a systematic ancient DNA survey appropriately sized bovid from Later Stone Age deposits four South African archaeological sites. show that none tested originated cattle. The precise date cattle region awaits further study, although we also new radiocarbon...
Abstract Background Gout, the most common inflammatory arthritis disease, and hyperuricaemia onset are influenced by environmental genetic factors. We sought to investigate these factors in an Indigenous community Guam. Methods In this cross-sectional study, University of Guam led qualitative inquiry with native community, training (pre-screening participants, data collection methods, biospecimen handling), study implementation (outreach recruitment, collection, DNA extraction...
<h3>Background</h3> Mitochondria appear to play a central role in the induction of an NLRP3 inflammatory response, immune response critical for development gouty pathology. are part self-encoding, possessing 16.5 kB circular genome which encodes 36 genes. Therefore mitochondrial genetic variation may contribute susceptibility gout. <h3>Objectives</h3> The objective this study was test whether and copy number among New Zealand Polynesians be contributing Māori Pacific (Polynesian) populations...