A5032060235- Bone Tissue Engineering Materials
- Collagen: Extraction and Characterization
- Polymer Surface Interaction Studies
- Dental Implant Techniques and Outcomes
- Silk-based biomaterials and applications
- Electrospun Nanofibers in Biomedical Applications
- biodegradable polymer synthesis and properties
- Calcium Carbonate Crystallization and Inhibition
- Mesoporous Materials and Catalysis
- 3D Printing in Biomedical Research
- Dental materials and restorations
- Periodontal Regeneration and Treatments
- Hydrogels: synthesis, properties, applications
- Nanoparticle-Based Drug Delivery
- Orthopaedic implants and arthroplasty
- Additive Manufacturing and 3D Printing Technologies
- Chemical Synthesis and Characterization
- Osteoarthritis Treatment and Mechanisms
- Bone health and treatments
- Cancer Treatment and Pharmacology
- Microfluidic and Bio-sensing Technologies
- Proteoglycans and glycosaminoglycans research
- Bone and Dental Protein Studies
- Radioactive element chemistry and processing
- Luminescence Properties of Advanced Materials
Tokyo Institute of Technology
2016-2025
National Science and Technology Development Agency
2023
Tokai University
2013
National Institute for Materials Science
2002-2011
Kanazawa Institute of Technology
2009
TU Dresden
2009
Hokkaido University
2009
Japan Science and Technology Agency
2001-2005
Yokohama City University
2001
Waseda University
1998-1999
Rattle-type Fe(3)O(4)@SiO(2) hollow mesoporous spheres with different particle sizes, shell thicknesses, and levels of Fe(3)O(4) content are prepared by using carbon as templates. The effects size concentration on cell uptake their in vitro cytotoxicity to HeLa cells evaluated. exhibit relatively fast uptake. Concentrations up 150 microg mL(-1) show no cytotoxicity, whereas a 200 shows small amount after 48 h incubation. Doxorubicin hydrochloride (DOX), an anticancer drug, is loaded into the...
Rattle-type Fe3O4@SiO2 hollow mesoporous spheres with large cavities have been successfully prepared by using the colloidal carbon as templates. The are well monodisperse and nearly uniform in dimension particle size of ca. 900 nm. thickness silica shell is about 100 nm, only one Fe3O4 nm diameter encapsulated each sphere. magnetic measurement indicated that exhibited ferromagnetic behavior magnetization saturation 1.6 emu/g. Using aspirin a model drug, showed high drug loading capacity...
To date, collagen for biomedical uses has been obtained from mammalian sources. The purpose of this study was to evaluate the in vivo biological responses and bioresorption tilapia (Oreochromis niloticas) scales as compared those porcine dermis. Collagen sponges with micro-porous structures were fabricated reconstituted fibrils using freeze-drying cross-linked by dehydrothermal treatment (DHT treatment) or additional a water-soluble carbodiimide (WSC treatment). mechanical properties similar...
Abstract We studied the effect of fibril formation fish scale collagen on osteoblastic differentiation human mesenchymal stem cells (hMSCs). found that hMSCs adhered easily to tilapia collagen, which remarkably accelerated early stage in during vitro cell culture. Osteoblastic markers such as ALP activity, osteopontin, and bone morphogenetic protein 2 were markedly upregulated when cultured a surface, especially stage. hypothesized this phenomenon occurs due specific collagen. Thus, we...
Abstract This study investigated the effects of three‐dimensional (3‐D) pore structure a porous hydroxyapatite/collagen (HAp/Col) composite on their mechanical properties and in vivo tissue ingrowth. The unique 3‐D structure, comprising unidirectionally interconnected pores, was fabricated by unidirectional growth ice crystals using cooling stage subsequent freeze‐drying process. pores had spindle‐shaped cross section, size gradually increased from bottom to upper face. showed an elastic...
Because calcium phosphate (Ca-P) ceramics have been used as bone substitutes, it is necessary to investigate what effects the on osteoblast maturation. We prepared three types of Ca-P with different ratios, i.e. hydroxyapatite (HA), beta-tricalcium (β-TCP), and biphasic (BCP) dense-smooth porous structures. Comprehensive gene expression microarray analysis mouse osteoblast-like cells cultured these revealed that considerably affected profiles, having a higher potential for In in vivo study...
Europium(III) (Eu3+/Eu(III)) substitution in the hydroxyapatite (HAp) lattice imparts luminescence properties, enabling its application diagnostics and bioimaging. Despite numerous experimental studies, there has been a lack of comprehensive discussion on behavior local structural stability Eu3+ within HAp. In this study, first-principles investigations were integrated to explore understand Optimization various HAp models revealed dependency site charge compensation mechanism. prefers Ca(2)...
The structure of many native tissues consists aligned collagen (Col) fibrils, some which are further composited with dispersed hydroxyapatite (HAp) nanocrystals. Accurately mimicking this inherent is a promising approach to enhance scaffold biocompatibility in tissue engineering. In study, biomimetic sheets composed highly Col fibrils were fabricated using plastic compression and tension method, followed by the deposition HAp nanocrystals on surface via an alternate soaking method. exhibited...