A5100610443- Cancer-related molecular mechanisms research
- interferon and immune responses
- Electrospun Nanofibers in Biomedical Applications
- Circular RNAs in diseases
- MicroRNA in disease regulation
- NF-κB Signaling Pathways
- Silk-based biomaterials and applications
- Fatty Acid Research and Health
- Molecular Biology Techniques and Applications
- RNA Research and Splicing
- Advanced Glycation End Products research
- Kruppel-like factors research
- Cancer, Hypoxia, and Metabolism
- Blood Coagulation and Thrombosis Mechanisms
- Computational Drug Discovery Methods
- HER2/EGFR in Cancer Research
- Cell Adhesion Molecules Research
- Angiogenesis and VEGF in Cancer
- Tissue Engineering and Regenerative Medicine
- Retinal Diseases and Treatments
- 3D Printing in Biomedical Research
- Nerve injury and regeneration
- Biomedical Text Mining and Ontologies
- Natural Antidiabetic Agents Studies
- Iron Metabolism and Disorders
Wannan Medical College
2024
First Affiliated Hospital of Wannan Medical College
2020-2024
Second Affiliated Hospital of Soochow University
2010-2021
Soochow University
2010-2021
Nantong University
2021
Jiangsu Vocational College of Medicine
2021
Pudong Medical Center
2017
Fudan University
2017
Indiana University – Purdue University Indianapolis
2015
Indiana University School of Medicine
2015
Previous reports indicated that long noncoding RNA 662 (LINC00662) plays a crucial role in several human cancers. Here, we studied the expression pattern of LINC00662 and explored its function breast cancer. The level was determined cancer cell lines tissues by real-time quantitative polymerase chain reaction (RT-qPCR). Cytoplasmic nuclear from MDA-MB-157 cells were extracted to analyze subcellular location LINC00662. Moreover, MTT assay, wound-healing colony-forming assay transwell employed...
We propose to study a novel pharmacovigilance problem for mining directional effects of high‐order drug interactions on an adverse event (ADE). Our goal is estimate each individual risk adding new existing combination. In this proof‐of‐concept study, we analyzed large electronic medical records database and extracted myopathy‐relevant case control co‐occurrence data. applied frequent itemset discover combinations within the data, evaluated related these combinations, identified with effect...
Objective: Glioblastomas multiforme (GBM) is the most malignant brain cancer, which presented vast genomic variation with complicated pathologic mechanism.
Tumor necrosis factor (TNF) receptor-associated 4 (TRAF4) is an adapter molecule that overexpressed in certain cancers. TRAF4 osteosarcoma tissues and cells. Using the technique of RNA interference, expression human Saos-2 cell line was shown to be downregulated. The proliferation, cycle arrest apoptosis ability Saos‑2 cells were examined, as tumor development a xenograft mouse model. results showed knockdown exerts inhibitory effects on proliferation Simultaneously, it found led G1 phase...
Transplantation of olfactory ensheathing cells (OECs) has potential for treating spinal cord and brain injury. However, they are void an extracellular matrix to support cell growth migration. Engineering tissue mimic the is a solution neural repair. Tussah silk fibroin (TSF) good biocompatibility Arg‑Gly‑Asp tripeptide sequence. A small number studies have assessed effect diameter TSF nanofibers on adhesion, In present study, with 400 1,200 nm were prepared using electrospinning technology;...
Glioma is the most common primary tumour in central nervous system adults, and at present, there no effective treatment to cure this malignancy. Long noncoding RNAs (lncRNAs) are closely related progression have attracted increasing attention research. However, role of lncRNA FGF14-AS2 glioma tumorigenesis has not been determined. In present study, we found that expression was significantly elevated tissues associated with poor survival patients. Silencing inhibited proliferation, migration...
Lung cancer is a type of malignant tumor which threats human health and life. Its morbidity might increase dramatically in long period. the leading cause cancer-related death all over world. HMGB1 (high mobility group box B 1) non-histone chromosome binding protein cells. It takes part many biological processes including genes transcription DNA repair. overexpression can result cell apoptosis, differentiation, migration proliferation. The main purpose this study was to detect expression 4...
To bridge the gap between 2D cell culture and tissue, various 3D approaches have been developed for investigation of cardiac myocytes (CM) fibroblasts (CF), but limitations still exist. The goal this study was to develop a scaffold-free that could easily inexpensively create many uniform microtissues mimic cellular distribution functional behavior CM CF in tissue. Using micromolded non-adhesive agarose hydrogels containing 822 concave recesses (800 λm deep x 400 wide), we demonstrate...