A5009315161- Forensic Toxicology and Drug Analysis
- Antibiotics Pharmacokinetics and Efficacy
- Pharmaceutical and Antibiotic Environmental Impacts
- Analytical Methods in Pharmaceuticals
- SARS-CoV-2 detection and testing
- Biosimilars and Bioanalytical Methods
- Analytical Chemistry and Chromatography
- Analytical chemistry methods development
- Bacterial Identification and Susceptibility Testing
- Pesticide Residue Analysis and Safety
- Pesticide Exposure and Toxicity
- Pharmacological Effects and Toxicity Studies
- Alcohol Consumption and Health Effects
- Hormonal and reproductive studies
- Epilepsy research and treatment
- Pharmaceutical studies and practices
- Pharmacological Effects and Assays
- Biosensors and Analytical Detection
- Erythropoietin and Anemia Treatment
- Mass Spectrometry Techniques and Applications
- Indoor Air Quality and Microbial Exposure
- Pneumonia and Respiratory Infections
- Neonatal Health and Biochemistry
- Chronic Lymphocytic Leukemia Research
- Bipolar Disorder and Treatment
Universidade Feevale
2011-2024
The determination of cocaine (COC) and its metabolites ecgonine methyl ester (EME), benzoylecgonine (BZE), norcocaine (NCOC) cocaethylene (CE) in human plasma is relevant clinical forensic toxicology. An efficient extraction clean-up specimens for the simultaneous BZE along with COC basic challenging due to their widely different polarities ionization characteristics. Recently, biocompatible SPME LC tips C18 became commercially available. We applied COC, BZE, EME, NCOC, CE by direct...
Background: The measurement of meropenem plasma concentrations is employed for dosing regimen individualization. aim this study was to develop and validate a LC–MS/MS assay quantification in capillary microsamples. Methods: Samples were prepared by protein precipitation with acetonitrile, followed clean-up dichloromethane. method validated applied 12 paired samples venous plasma. Results: linear the range 0.5–50 μg/ml. Matrix effects minimal. Inter- intra-assay 3.8–7.9% 2.7–5.5%,...
Therapeutic drug monitoring (TDM) of gentamicin sulfate (GEN) is usually recommended, particularly in critical patients. Only a few reports had described the determination GEN plasma or using LC-MS/MS.
Background: Dried blood spot sampling has been reported for on-site collection of specimens, but measurements are affected by hematocrit, and special handling is required, especially forensic applications. The hemaPEN® device was developed to produce spots with constant volume. Results: Linearity between 1 500 ng/ml shown cocaine the metabolites benzoylecgonine cocaethylene. assay demonstrated acceptable precision accuracy, analytes were stable 7 days when kept inside hemaPEN devices....
Background: Workplace drug testing primarily relies on urine analysis, targeting multiple compounds with varying physicochemical characteristics. Biocompatible solid-phase microextraction (BioSPME) is a miniaturized extraction technique that enables the simultaneous and preconcentration of analytes directly from biological matrix. Methods: The BioSPME procedure consisted sequential 50-μl samples using LC Tips C18 in basic acidic pH, followed by desorption methanol n-hexane, respectively....
Benzene is an important environmental and occupational pollutant, recognized as human carcinogen.S-phenylmercapturic acid (SPMA) a highly specific biomarker of exposure to benzene, applied in toxicology assess low levels benzene exposure.The objective this study was develop validate one-step liquid extraction bioanalytical method for the quantification SPMA urine by chromatography-tandem mass spectrometry (LC-MS/MS).The evaluation setting.The assay linear from 0.5 500 ng mL -1...
Abstract The determination of psychotropic drugs and metabolites in blood is relevant the context both therapeutic drug monitoring clinical forensic toxicology. LC–MS/MS preferred method for these assays. However, particularly susceptible to matrix ionization effects appropriate sample preparation required minimize effects. In this study, a simple, single‐step, mini‐QuEchERS extraction procedure, coupled UPLC–MS/MS, was developed validated 15 toxicologically compounds whole blood, including...
Identifying drugs of abuse and their metabolites in plasma is vital both forensic clinical toxicology. While the QuEChERS (Quick, Easy, Cheap, Effective, Rugged Safe) method offers an efficient approach to sample preparation, its application complex due wide-ranging properties target analytes challenges posed by biological matrix interferences. This study aims develop a microQuEChERS for quantification 14 utilizing minimal solvent volumes.
The abuse of legal and illegal drugs is a global public health problem, also affecting the social economic well-being population. Thus, there significant interest in monitoring drug consumption. Relevant epidemiological information on lifestyle habits can be obtained from chemical analysis urban wastewater. In this work, passive sampling using polar organic integrative samplers (POCIS) was used to quantify biomarkers wastewater for application wastewater-based epidemiology (WBE). WBE study,...
INTRODUCTION: About 38 million people are exposed to carbamazepine per year for the treatment of epilepsy. The drug is on WHO essential list. epilepsy happens in a prophylactic way, provide patient with better life condition. Therefore, addition choice medication and dose required everyone, adherence therapy also great importance functioning treatment. Fingerprint widely used forensic area, this matrix also appearing toxicological clinical find out if individual has ingested substance....
Introduction: Individuals undergoing treatment for epilepsy may have difficulty adhering to treatment. Among the reasons, forgetfulness and adverse effects caused by medication can be highlighted. With this scenario, it is understood that there a need carry out therapeutic monitoring of patients epilepsy. The OneDraw device, which allows you obtain capillary blood sample from its fixation in upper part arm, eliminates some obstacles encountered collecting finger, such as pain, discomfort...