A5093941041- Antifungal resistance and susceptibility
- Fungal Infections and Studies
- Nail Diseases and Treatments
- Antimicrobial Peptides and Activities
- Biochemical and Structural Characterization
- Peptidase Inhibition and Analysis
- Mycotoxins in Agriculture and Food
Universidade de Ribeirão Preto
2024
Universidade de São Paulo
2024
ABSTRACT Cryptococcus neoformans causes cryptococcosis, one of the most prevalent fungal diseases, generally characterized by meningitis. There is a limited and not very effective number drugs available to combat this disease. In manuscript, we show host defense peptide mimetic brilacidin (BRI) as promising antifungal drug against C. . BRI can affect organization cell membrane, increasing permeability. We also investigated effects model system Saccharomyces cerevisiae analyzing libraries...
ABSTRACT Sporotrichosis, the cutaneous mycosis most commonly reported in Latin America, is caused by Sporothrix clinical clade species, including brasiliensis and schenckii sensu stricto . Due to its zoonotic transmission Brazil, S. represents a significant health threat humans domestic animals. Itraconazole, terbinafine, amphotericin B are used antifungals for treating sporotrichosis. However, many strains of have shown resistance these agents, highlighting importance finding new...
Sporotrichosis, the cutaneous mycosis most commonly reported in Latin America, is caused by
Abstract Aspergillus fumigatus is the primary etiological agent of aspergillosis. Here, we show that host defense peptide mimetic, brilacidin (BRI) can potentiate ibrexafungerp (IBX) against clinical isolates A. . CAS-resistant strains with mutations in fks1 encodes 1,3-β-D-glucan synthase are not IBX-resistant and BRI+IBX inhibit their growth. The combination plays a fungicidal role, increases fungal cell permeability decreases survival presence A549 epithelial cells.
Abstract Cryptococcus neoformans causes cryptococcosis, one of the most prevalent fungal diseases, generally characterized by meningitis. There is a limited and not very effective number drugs available to combat this disease. In manuscript, we show host defense peptide mimetic brilacidin (BRI) as promising antifungal drug against C. . BRI able affect organization cell membrane, increasing permeability. We also investigated effects model system Saccharomyces cerevisiae analyzing libraries...
ABSTRACT Aspergillus fumigatus is the primary etiological agent of aspergillosis. Here, we show that host defense peptide mimetic brilacidin (BRI) can potentiate ibrexafungerp (IBX) against clinical isolates A. . BRI + IBX inhibit growth voriconazole- and caspofungin-resistant isolates. a small molecule has previously exhibited broad-spectrum immunomodulatory/anti-inflammatory activity viruses, bacteria, fungi. In vitro , combination plays fungicidal role, increases fungal cell permeability,...