A5074599484- Tuberculosis Research and Epidemiology
- Environmental Justice and Health Disparities
- Regulation and Compliance Studies
- Species Distribution and Climate Change
- Conservation, Ecology, Wildlife Education
- Fungal and yeast genetics research
- Photosynthetic Processes and Mechanisms
- Wheat and Barley Genetics and Pathology
- Economic and Environmental Valuation
- Rangeland and Wildlife Management
- Immune Response and Inflammation
- Ecology and Vegetation Dynamics Studies
- Mycobacterium research and diagnosis
- Pain Management and Placebo Effect
- Legal and Constitutional Studies
- Plant Disease Resistance and Genetics
- Microbial infections and disease research
- Forest Management and Policy
- Plant pathogens and resistance mechanisms
- Immunodeficiency and Autoimmune Disorders
- Cytokine Signaling Pathways and Interactions
- Diagnosis and treatment of tuberculosis
- Plant-Microbe Interactions and Immunity
- Academic and Historical Perspectives in Psychology
- International Maritime Law Issues
Loewe Center for Synthetic Microbiology
2020-2025
Philipps University of Marburg
2023-2025
United States Department of Justice
2002
Indiana University Bloomington
1996-1999
University of Southern California
1999
Harvard University Press
1997
University of Bonn
1934-1948
Abstract The major pathogen Staphylococcus aureus has to cope with host‐derived oxidative stress cause infections in humans. Here, we report that S. tolerates high concentrations of hypothiocyanous acid (HOSCN), a key antimicrobial oxidant produced the respiratory tract. We discovered flavoprotein disulfide reductase (FDR) MerA protects from this by functioning as HOSCN reductase, its deletion sensitizing bacteria HOSCN. Crystal structures homodimeric (2.4 Å) Cys 43 –Cys 48 intramolecular...
The alarmones (p)ppGpp play a critical role in chloroplasts by acting as signalling molecules that regulate gene expression, protein synthesis and chloroplast ( cp ) development, particularly response to stress nutrient availability. However, the underlying molecular mechanisms are still poorly understood. Here, we show binds GTPase‐containing NG domains of signal recognition particle (SRP) its receptor, preventing their GTP‐dependent association through competitive mechanism. structure...
The biotrophic fungus Ustilago maydis, which causes smut disease in maize, secretes numerous proteins upon plant colonization. Some of them, termed effectors, help to evade defenses and manipulate cellular processes within the host. function many specifically secreted during infection remains elusive. In this study, we biochemically characterized one such protein, UMAG_00027, that is highly expressed infection. We show UMAG_00027 a protein with lectin-like fold therefore term it Llp1...
Abstract: Conservation biology has provided wildlife managers with a wealth of concepts and tools for use in conservation planning; among them is the surrogate species concept. Over past 20 years, growing body empirical literature demonstrated limited effectiveness surrogates as management tools, unless it first established that target will respond similarly to given set environmental conditions. Wildlife policy makers have adopted concept, reflecting information available on most at risk...
The Endangered Species Act's best available science mandate has been widely emulated and reflects a Congressional directive to ensure that decisions made under the Act are informed by reliable knowledge applied using structured approach. We build on standing literature describing role of in implementation practices can be employed realize directive. Next we describe recurring impediments realizing determinations federal wildlife agencies based science. then identify types data, analyses,...
Abstract Highly specific interactions between proteins are a fundamental prerequisite for life, but how they evolve remains an unsolved problem. In particular, initially unrelated require that matching surfaces. It is unclear whether such surface compatibilities can only be built by selection in small incremental steps, or also emerge fortuitously. Here, we used molecular phylogenetics, ancestral sequence reconstruction and biophysical characterization of resurrected to retrace the evolution...
Abstract Plant‐pathogenic fungi are causative agents of the majority plant diseases and can lead to severe crop loss in infected populations. Fungal colonization is achieved by combining different strategies, such as avoiding counteracting immune system manipulating host metabolome. Of major importance virulence factors secreted fungi, which fulfil diverse functions support infection process. Most these proteins highly specialized, with structural biochemical information often absent. Here,...
Scientists and policy makers have shown great industry in popularizing the concept of adaptive management for imperiled species, principally by promulgating slightly varying, multi-step adaptive-management cycles. Thirty years after appearance scientific literature, has gained acceptance as a readily recognized, conceptually simple conservation-planning vehicle, despite its lackluster track record. Successful must be implemented step-wise, structured approach to incorporating information...
This article examines current policy concerning the interstate transport of waste with particular reference to relative role different levels government in shaping and implementing management five key United States Supreme Court cases two recent Appeals cases. The intergovernmental tensions between federal courts state local governments are highlighted, clashes law discussed, implications for public analyzed.
Many plant-pathogenic bacteria and fungi deploy effector proteins that down-regulate plant defense responses reprogram metabolism for colonization survival in planta. Kiwellin (KWL) are a widespread family of plant-defense target these microbial effectors. The KWL1 protein from maize (corn, Zea mays) specifically inhibits the enzymatic activity secreted chorismate mutase Cmu1, virulence-promoting smut fungus Ustilago maydis. In addition to KWL1, 19 additional KWL paralogs have been...
The use of surrogates in conservation planning for at-risk species is both a necessary and fraught practice. Here we assess the position low-salinity zone California's Sacramento-San Joaquin Delta as surrogate extent quality habitat available to imperiled delta smelt. U.S. Fish Wildlife Service issued biological opinion incidental take statement under Endangered Species Act analyzing impacts ongoing operation two large water infrastructure projects on Service's analysis actions it imposed...
The US Fish and Wildlife Service National Marine Fisheries recently proposed to amend existing regulations that implement the Endangered Species Act’s interagency consultation process by codifying their pre-existing practice of using surrogates express amount or extent incidental take listed species. agencies contend amendments both are necessary as a practical matter defensible on ecological grounds. They propose use surrogates, either in form substitute species filling for is challenging...
The directive from Congress in the Endangered Species Act obliging US Fish and Wildlife Service National Marine Fisheries along with other federal agencies to use best available scientific information their determinations-and calls stakeholder communities show that they have done so-have led wildlife seek external, expert review of determinations increasing frequency over time. In present article, we survey agency may be subject independent science technical tasks embedded those can benefit...