A5063125852- Atrial Fibrillation Management and Outcomes
- Cardiac Arrhythmias and Treatments
- Cardiac electrophysiology and arrhythmias
- Cardiac Imaging and Diagnostics
- Cardiac pacing and defibrillation studies
- Cardiovascular Function and Risk Factors
- Health Systems, Economic Evaluations, Quality of Life
- Cardiovascular Disease and Adiposity
- ECG Monitoring and Analysis
- Venous Thromboembolism Diagnosis and Management
- Cardiovascular and Diving-Related Complications
- Vitamin K Research Studies
- Pharmaceutical Economics and Policy
- Cardiovascular Syncope and Autonomic Disorders
- Takotsubo Cardiomyopathy and Associated Phenomena
- Acute Ischemic Stroke Management
- Restraint-Related Deaths
- Inflammatory Biomarkers in Disease Prognosis
- Lipid metabolism and disorders
- Botulinum Toxin and Related Neurological Disorders
- Poisoning and overdose treatments
- Neuroscience and Neural Engineering
- Ion channel regulation and function
- Cardiovascular Effects of Exercise
- Heart Rate Variability and Autonomic Control
Maastricht University Medical Centre
2013-2025
Zuyderland Medisch Centrum
2025
Amsterdam University Medical Centers
2025
University of Amsterdam
2025
Maastricht University
2013-2023
Luisenhospital Aachen
2021-2023
Radboud University Nijmegen
2023
Radboud University Medical Center
2023
University Medical Center
2016
VieCuri Medisch Centrum
2016
AimsVitamin K antagonists (VKA) are currently the most frequently used drug to prevent ischaemic stroke in atrial fibrillation (AF) patients. However, VKA use has been associated with increased vascular calcification. The aim of this study was investigate contribution coronary artery calcification low-risk AF
<h3>Background:</h3> The total atrial conduction time (TACT) is an independent predictor of fibrillation (AF). A new transthoracic echocardiographic tool to determine TACT by tissue Doppler imaging (PA-TDI (the from the initiation P wave on ECG (lead II) A′ lateral left tracing)) has been developed recently. <h3>Objective:</h3> To test hypothesis that measurement PA-TDI enables prediction new-onset AF. <h3>Methods:</h3> 249 Patients without a history AF were studied. All patients underwent...
Abstract Aims Evaluation of (i) the effects a virtual reality (VR) preprocedural patient education video on information provision, procedure-related knowledge, satisfaction, and level worries in patients planned for atrial fibrillation (AF) ablation (ii) feasibility disposable cardboard VR viewer home use this setting. Methods results In prospective observational cohort study, were alternatively assigned 1:1 ratio to control or group. Controls received standard information. group (via...
Purpose of review The aim this is to examine recent advancements in RNA-targeted therapies for the management severe hypertriglyceridemia (sHTG) and prevention sHTG-associated acute pancreatitis. Recent findings developments therapies, aimed at inhibiting apolipoprotein C-III (apoC-III), have demonstrated substantial sustained reductions triglyceride levels. Novel including antisense oligonucleotides (ASOs) small interfering RNA (siRNA), such as volanesorsen, olezarsen, plozasiran, shown...
Progression of atrial fibrillation (AF) from paroxysmal to persistent forms is an active field research. The influence AF progression on health related quality life (HRQoL) currently unknown. We aimed assess the HRQoL, and whether this association mediated through symptoms, treatment, major adverse events.In Euro Heart Survey, 967 patients were included with who filled out EuroQoL-5D at baseline 1 year follow-up. Those progressed (n = 132, 13.6%) developed more problems during follow-up than...
Introduction Atrial fibrillation (AF) is associated with dementia. Anticoagulation may modify this relationship, but it unclear if due to stroke reduction alone. Methods Age- and sex-matched individuals from the U.K. Clinical Practice Research Datalink (2008–2016) without an incident diagnosis of AF were followed for a new dementia diagnosis. We estimated adjusted hazard ratios (aHRs) in cohort, overall stratified by anticoagulation status, using matched non-AF cohorts as reference....
Abstract Background Venous thromboembolism (VTE) is a major cause of death in cancer patients. Although patients with have numerous risk factors for VTE, the relative contribution treatments unclear. Objective The objective this study to evaluate association between therapies and VTE. Methods From UK Clinical Practice Research Datalink, data on first diagnosis 2008 2016 were extracted along information hospitalization, treatments, death. Primary outcome was active cancer-associated To...
AimsAn age of 60 years is often used as cut-off for the diagnosis idiopathic atrial fibrillation (AF). We investigated importance and size in patients with AF isolated hypertension.
AimsThe total atrial conduction time (TACT) is an important electrophysiological parameter. We developed a new transthoracic echocardiographic tool (PA-TDI). The PA-TDI interval reflection of the TACT. In present study, we evaluated clinical and correlates intra-atrial delay.
Idiopathic atrial fibrillation (AF) may be an expression of as yet undetected underlying heart disease. We found it useful for clinical practice to study the long-term development cardiovascular disease (CVD) in patients diagnosed with idiopathic AF. Forty-one consecutive AF (56 ± 10 years, 66% male) were compared 45 healthy control permanent sinus rhythm. Patients free hypertension, antihypertensive and antiarrhythmic drugs, diabetes, congestive failure, coronary artery or peripheral...
Left bundle branch area pacing (LBBAP) has recently been introduced as a physiological technique with synchronous left ventricular activation. It was our aim to evaluate the feasibility and learning curve of technique, well electrical characteristics LBBAP.LBBAP attempted in 80 consecutive patients electrocardiographic were evaluated during intrinsic rhythm, right septum (RVSP) LBBAP. Permanent lead implantation successful 77 (96%). LBBAP time fluoroscopy shortened significantly from 33 ± 16...
Background Vitamin K antagonists (VKAs) are associated with coronary artery calcification in low-risk populations, but their effect on of large arteries remains uncertain. The non-vitamin antagonist oral anticoagulants (NOACs) vascular is unknown. We investigated the influence use VKA and NOAC aorta aortic valve. Methods In patients atrial fibrillation without a history major adverse cardiac or cerebrovascular events who underwent computed tomographic angiography, presence ascending (AsAC),...
Atrial fibrillation (AF) reduces quality of life (QoL). We aim to evaluate effects targeted therapy underlying conditions on QoL in patients with AF and heart failure (HF).The Routine versus Aggressive risk factor driven upstream rhythm Control for prevention Early atrial (RACE 3) study randomized early persistent HF or conventional therapy. Both groups received guideline-driven treatment. The group four additional therapies: mineralocorticoid receptor antagonists; statins; angiotensin...
ABSTRACT Aim A recent European Heart Rhythm Association (EHRA) practical guide provides guidance on the use of novel digital devices for heart rhythm analysis using either electrocardiogram (ECG) or photoplethysmography (PPG) technology diagnosis atrial fibrillation (AF). This survey assesses physicians' preferences to in patients with possible AF and their impact clinical decision‐making. Methods Results Participants DAS‐CAM III initiated distributed an online assessing physician management...
Abstract Aims Maintaining sinus rhythm in patients with persistent atrial fibrillation (AF) is challenging. We explored the efficacy of class I and III antiarrhythmic drugs (AADs) AF mild to moderate heart failure (HF). Methods results In RACE 3 trial, early symptomatic short history HF preserved or reduced left ventricular ejection fraction (LVEF) were randomized targeted conventional therapy. Both groups received guideline-driven treatment. Additionally, targeted-group mineralocorticoid...
A standard coronary artery calcium scan includes part of the aorta. This additional information is often not included in routine analyses. We aimed to determine feasibility assessing Agatston score descending aorta calcification (DAC) on scans and association this with events a low-risk study population.Between January 2008 March 2011, 390 consecutive patients who were referred for cardiac CT as work-up pulmonary vein isolation (n=115) or assessment presence disease (n=275) included. At...
In patients with atrial fibrillation (AF), echocardiographic tissue velocity imaging (TVI) enables assessment of electrical and structural remodelling by measuring, respectively, the AF cycle length (AFCL-TVI) fibrillatory wall motion (AFV-TVI). We investigated clinical correlates assessed TVI. studied 215 presenting AF. all patients, we measured AFCL-TVI AFV-TVI in left atrium. Standard baseline characteristics were recorded. divided median value to evaluate determinants remodelling. A low...