A5074364271- Atrial Fibrillation Management and Outcomes
- Cardiac Arrhythmias and Treatments
- Cardiac electrophysiology and arrhythmias
- Cardiac pacing and defibrillation studies
- Cardiovascular Disease and Adiposity
- Cardiovascular Function and Risk Factors
- Cardiovascular Health and Disease Prevention
- Cardiac Valve Diseases and Treatments
- Genetic Associations and Epidemiology
- Cardiac Fibrosis and Remodeling
- Cardiac Imaging and Diagnostics
- Venous Thromboembolism Diagnosis and Management
- Healthcare Systems and Public Health
- Blood Coagulation and Thrombosis Mechanisms
- Bioinformatics and Genomic Networks
- Takotsubo Cardiomyopathy and Associated Phenomena
- Antiplatelet Therapy and Cardiovascular Diseases
- Heart Failure Treatment and Management
- Acute Myocardial Infarction Research
- Genomics and Rare Diseases
- Peptidase Inhibition and Analysis
- Coronary Interventions and Diagnostics
- Vitamin K Research Studies
- GDF15 and Related Biomarkers
- Hydrogen embrittlement and corrosion behaviors in metals
Maastricht University Medical Centre
2015-2025
Maastricht University
2014-2023
Cardiovascular Institute Hospital
2019
University of Birmingham
2018
Memorial Health University Medical Center
2016
Tokyo Metropolitan Hiroo Hospital
2015
Grodno State Medical University
2015
Clinique Pasteur
2015
University Medical Center
2015
Patients with recent-onset atrial fibrillation commonly undergo immediate restoration of sinus rhythm by pharmacologic or electrical cardioversion. However, whether is necessary not known, since often terminates spontaneously.
QRS duration and left bundle branch block (LBBB) morphology are used to select patients for cardiac resynchronization therapy (CRT). We investigated whether the area of complex (QRSAREA) on 3-dimensional vectorcardiogram (VCG) can improve patient selection. VCG (Frank orthogonal lead system) was recorded prior CRT device implantation in 81 consecutive patients. parameters, including QRSAREA, were assessed, compared morphology. Three LBBB definitions used, differing requirement mid-QRS...
Atrial fibrillation (AF) is a progressive disease, but identifying patients at risk for AF progression challenging. We aimed to identify factors associated with progression.Atrial was assessed in 392 recent-onset paroxysmal or persistent included the prospective, observational, multicentre identification of profile guide atrial (AF-RISK) study. Progression by Holter monitoring and 2-week event recorder baseline 1-year follow-up. defined as: (i) doubling burden 1 year compared minimum 10% AF;...
Abstract Atherothrombosis is a leading cause of cardiovascular mortality and long-term morbidity. Platelets coagulation proteases, interacting with circulating cells in different vascular beds, modify several complex pathologies including atherosclerosis. In the second Maastricht Consensus Conference on Thrombosis, this theme was addressed by diverse scientists from bench to bedside. All presentations were discussed audience members results these discussions incorporated final document that...
Progression of atrial fibrillation (AF) from paroxysmal to persistent forms is an active field research. The influence AF progression on health related quality life (HRQoL) currently unknown. We aimed assess the HRQoL, and whether this association mediated through symptoms, treatment, major adverse events.In Euro Heart Survey, 967 patients were included with who filled out EuroQoL-5D at baseline 1 year follow-up. Those progressed (n = 132, 13.6%) developed more problems during follow-up than...
Atrial fibrillation (AF) is associated with a wide range of clinical presentations. Whether and how AF symptoms can affect prognosis still unclear. Aims the present analysis were to investigate potential predictors symptomatic determine if are higher incidence cardiovascular (CV) events at 1-year follow-up.The Euro Heart Survey on Fibrillation included 3607 consecutive patients documented available follow-up regarding status. Patients found baseline classified into (SS group; n = 896)...
Abstract Early detection of atrial fibrillation (AF) enables initiation anticoagulation and early rhythm control therapy to reduce stroke, cardiovascular death, heart failure. In a cross-sectional, observational study, we aimed identify combination circulating biomolecules reflecting different biological processes detect prevalent AF in patients with conditions presenting hospital. Twelve biomarkers identified by reviewing literature patents were quantified on high-precision, high-throughput...
Background Vitamin K antagonists (VKAs) are associated with coronary artery calcification in low-risk populations, but their effect on of large arteries remains uncertain. The non-vitamin antagonist oral anticoagulants (NOACs) vascular is unknown. We investigated the influence use VKA and NOAC aorta aortic valve. Methods In patients atrial fibrillation without a history major adverse cardiac or cerebrovascular events who underwent computed tomographic angiography, presence ascending (AsAC),...
Cardiovascular I kit to identify markers associated with the presence of AF in otherwise healthy patients, enabling identification www.jafib.com
A standard coronary artery calcium scan includes part of the aorta. This additional information is often not included in routine analyses. We aimed to determine feasibility assessing Agatston score descending aorta calcification (DAC) on scans and association this with events a low-risk study population.Between January 2008 March 2011, 390 consecutive patients who were referred for cardiac CT as work-up pulmonary vein isolation (n=115) or assessment presence disease (n=275) included. At...
Hypertension is a risk factor for both progression of atrial fibrillation (AF) and development AF-related complications, that major adverse cardiac cerebrovascular events (MACCE). It unknown whether left ventricular hypertrophy (LVH) as consequence hypertension also these end points. We aimed to assess this in low-risk AF patients, assessing gender-related differences. included 799 patients from the Euro Heart Survey with nonvalvular baseline echocardiogram. Patients without were included....
Current standard of care for patients with recent-onset atrial fibrillation (AF) in the emergency department aims at urgent restoration sinus rhythm, although paroxysmal AF is a condition that resolves spontaneously within 24 hours more than 70% cases. A wait-and-see approach rate-control medication only and when needed cardioversion 48 onset symptoms hypothesized to be noninferior, safe, cost-effective as compared current lead higher quality life.The ACWAS trial (NCT02248753) an...
Abstract Background Atrial tachyarrhythmias are common in patients with cardiac implantable electronic devices (CIEDs). Restoration of sinus rhythm by external electrical cardioversion (eECV) is frequently used to alleviate symptoms and ensure optimal device function. Objectives To evaluate the safety eECV contemporary CIEDs assess need for immediate interrogation after eECV. Methods We conducted a retrospective observational study 229 (27.9% female, age 69 ± 10 years) CIED (104 pacemakers,...
Background: Atrial Fibrillation (AF) in patients without concomitant cardiovascular pathophysiological disease, is called idiopathic (iAF). Nonetheless, iAF have often times subclinical coronary (micro) vascular dysfunction and, particularly women, a higher prevalence of subsequent comorbidities. Previously, we identified plasma miRNA association with diabetes and microvascular injury Diabetic Nephropathy (DN) patients. Therefore, this study assessed whether levels these diabetic, associated...
Healthy atrial fibrillation (AF) patients will eventually outgrow their low thromboembolic risk. The purpose of this study is to compare the development cardiovascular disease in healthy AF as compared sinus rhythm and assess appropriate anticoagulation treatment.Forty-one idiopathic paroxysmal (56 ± 10 years, 66% male) were with 45 patients. Patients free hypertension, antihypertensive antiarrhythmic drugs, diabetes, congestive heart failure, coronary artery or peripheral vascular disease,...
Abstract Background The current standard of care for acute atrial fibrillation (AF) focuses primarily on immediate restoration sinus rhythm by cardioversion, although AF often terminates spontaneously. Objective To identify determinants early spontaneous conversion (SCV) in patients presenting at the emergency department (ED) because AF. Methods An observational study was performed who visited ED with documented between July 2014 and December 2016. clinical characteristics demographics...
Circulating biomarkers are useful in detection and monitoring of cardiovascular diseases. However, their role aortic valve disease is unclear. Mechanisms rapidly elucidated sex differences suggested to be involved. Therefore, we sought identify involved calcification (AVC) stratified by sex.Blood samples 34 patients with AVC (without further overt disease, including absence hemodynamic consequences valvular calcification) were compared 136 without AVC. was determined using computed...
Objective The Rate Control versus Electrical Cardioversion Trial 7–Acute Wait and See trial compared early to delayed cardioversion for patients with recent-onset symptomatic atrial fibrillation (AF). This study aims evaluate the adherence a 4-week mobile health (mHealth) prescription detect AF recurrences after an emergency department visit. Methods After visit, 437 included patients, irrespective of randomisation arm (early or cardioversion), were asked record heart rate rhythm 1 min three...
Atrial fibrillation (AF) is a progressive disease, and early recognition management may reflect an important strategy to reduce its disease burden. In this study, we evaluated plasma levels of three biomarkers - N-terminal pro-brain natriuretic peptide (NTproBNP), Troponin-T, growth differentiation factor-15 (GDF-15) in patients with paroxysmal AF (pAF) (≤7 days continuous AF, n = 323) persistent ((AF duration > 7 < 1 year, 84) using from RISK study (NCT01510210). AF-RISK sub-study,...
BackgroundPatients undergoing elective electrical cardioversion (ECV) for atrial fibrillation have a temporarily increased risk of thromboembolism. Current guidelines recommend adequate anticoagulation ≥3 consecutive weeks precardioversion, i.e. INR values 2.0–3.0 in patients with vitamin K antagonists (VKA). We aimed to evaluate the occurrence and impact subtherapeutic INRs precardioversion study factors associated these unwanted fluctuations.MethodsWe recruited 346 ECV Maastricht...
Patients with a history of myocardial infarction and coronary artery disease (CAD) have higher risk developing AF. Conversely, patients atrial fibrillation (AF) infarction, suggesting link in underlying pathophysiology. The aim this study was to assess whether angiographic parameters are associated substrate for AF without AF.During cardiac surgery 62 (coronary bypass grafting (CABG;n = 47), aortic valve replacement (AVR;n 9) or CABG + AVR (n 6)) clinical (age 65.4 ± 8.5 years, 26.2%...