A5075936484- Atrial Fibrillation Management and Outcomes
- Cardiac Arrhythmias and Treatments
- Cardiac electrophysiology and arrhythmias
- Genetic Associations and Epidemiology
- Cardiovascular Function and Risk Factors
- Blood Coagulation and Thrombosis Mechanisms
- Cardiovascular Disease and Adiposity
- Cardiomyopathy and Myosin Studies
- Cardiovascular Health and Disease Prevention
- Cardiovascular Health and Risk Factors
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Infective Endocarditis Diagnosis and Management
- Health Systems, Economic Evaluations, Quality of Life
- Parkinson's Disease Mechanisms and Treatments
- Urticaria and Related Conditions
- Venous Thromboembolism Diagnosis and Management
- Autoimmune Bullous Skin Diseases
- ECG Monitoring and Analysis
- RNA regulation and disease
- Cardiac Valve Diseases and Treatments
- Telomeres, Telomerase, and Senescence
- Heart rate and cardiovascular health
- Antiplatelet Therapy and Cardiovascular Diseases
- Viral Infections and Immunology Research
- Nutrition, Genetics, and Disease
University Medical Center Groningen
2015-2022
University of Groningen
2015-2022
Massachusetts General Hospital
2016-2017
Broad Institute
2016
Massachusetts Institute of Technology
2016
Zentralklinik Bad Berka
2015
Shizuoka City Hospital
2015
Perm State Medical Academy
2015
Atrial fibrillation (AF) has a substantial genetic basis. Identification of individuals at greatest AF risk could minimize the incidence cardioembolic stroke.To determine whether data can stratify for development AF, we examined associations between scores and incident in 5 prospective studies comprising 18 919 European ancestry. We ischemic stroke separate study 509 cases (202 [40%]) 3028 referents. Scores were based on 11 to 719 common variants (≥5%) associated with P values ranging from...
Abstract Atherothrombosis is a leading cause of cardiovascular mortality and long-term morbidity. Platelets coagulation proteases, interacting with circulating cells in different vascular beds, modify several complex pathologies including atherosclerosis. In the second Maastricht Consensus Conference on Thrombosis, this theme was addressed by diverse scientists from bench to bedside. All presentations were discussed audience members results these discussions incorporated final document that...
Ablation is a widely used therapy for atrial fibrillation (AF); however, arrhythmia recurrence and repeat procedures are common. Studies examining surrogate markers of genetic susceptibility to AF, such as family history individual AF alleles, suggest these may be associated with outcomes. Accordingly, the aim this study was test association between after ablation using comprehensive polygenic risk score AF. Ten centers from Genetics Consortium identified patients who had undergone de novo...
Abstract Atrial fibrillation (AF) patients have enlarged left atria (LA), but prior studies suggested as both cause and consequence of AF. The aim this study is to investigate the causal association between AF LA size function. In UK Biobank, all individuals with contoured cardiovascular magnetic resonance data were selected. maximal volume (LA max), minimal min), stroke ejection fraction measured indexed body surface area (BSA). Two-sample Mendelian randomization analyses performed using 84...
Background Our aim is to present average values and prevalence of electrocardiographic ( ECG ) abnormalities among the general Dutch population in LifeLines Cohort. Hypothesis The previously studied Caucasian smaller cohorts will be confirmed with data from . Methods 152 180 individuals age 18 93 years were available. Individuals cardiovascular risk factors excluded analyze healthy population. Average for presented as means 95% 99% confidence intervals medians first 99th percentiles. Results...
Atrial fibrillation (AF) may present variously in time, and AF progress from self-terminating to non-self-terminating AF, is associated with impaired prognosis. However, predictors of types are largely unexplored. We investigate the clinical, biomarker, genetic development specific a community-based cohort.We included 8042 individuals (319 incident AF) PREVEND study. Types were compared, multivariate multinomial regression analysis determined associations AF.Mean age was 48.5 ± 12.4 years...
The incidence of atrial fibrillation (AF) increases with age. Telomere length is considered a marker biological ageing. We investigated the association between leukocyte telomere and incident AF in Dutch Prevention Renal Vascular End-stage Disease (PREVEND) study.We included 7775 individuals without prevalent AF, measured. Mean was determined by monochrome multiplex quantitative polymerase chain reaction-based assay.Mean age our cohort 49±13 years, 50% were men. During mean follow-up...
Abstract Objective We sought to assess whether genetic risk factors for atrial fibrillation can explain cardioembolic stroke risk. Methods evaluated correlations between a prior study of AF and in the presence using genome-wide genotypes from Stroke Genetics Network (N = 3,190 cases, 3,000 28,026 referents). tested previously-validated polygenic score (PRS) associated with other subtypes after accounting clinical factors. Results observed strong correlation previously reported AF, stroke,...
Background Risk prediction of atrial fibrillation (AF) is importance to improve the early diagnosis and treatment AF. Latent class analysis takes into account possible existence classes individuals each with shared risk factors, maybe a better method incorporating phenotypic heterogeneity underlying Methods findings Two prospective community-based cohort studies from Netherlands United States were used. Prevention Renal Vascular End-stage Disease (PREVEND) study, started in 1997, Framingham...
• Incident AF was detected in 249 (0.3%) individuals of the Lifelines population. Age, sex, body mass index, heart failure and stroke were associated with incident AF. Physical activity, nutritional status sleep quality not
Atrial fibrillation (AF) management has significantly improved during the career of professor Crijns. Research was implemented into guidelines and clinical practice. However, despite advances in AF management, large differences between individual treatment responses still exist mechanisms underlying initiation perpetuation are not completely understood. International collaborations have revealed genetic contribution to steps towards improving being made. In this short review, most important...
Aims Limited causal evidence is available on the relationship between body mass index (BMI) and atrial fibrillation (AF) progression. Sex differences have been noted may be relevant for AF We investigated association BMI Genetic Risk Score (GRS) progression in men women of Groningen Atrial Fibrillation (GGAF) cohort. Methods results The GGAF cohort (n = 2207) a composite 5 prospective cohorts with individuals European ancestry. patients genetic information, at least 12 months follow-up data...
Introduction: The clinical and pathophysiological heterogeneity variety of risk factors predisposing to AF is large.Better understanding the phenotypic those at for may allow better prediction.Latent class clustering analyses identification clusters individuals that share similar (specific profile), instead traditional analysis specific AF.Methods: We determined using a hypothesis-free, latent approach, compared performance with risk-factor-based prediction model in community-based PREVEND...