A5082073684- Animal Genetics and Reproduction
- Reproductive Biology and Fertility
- Genetic and phenotypic traits in livestock
- Veterinary Oncology Research
- Genomics and Phylogenetic Studies
- Gut microbiota and health
- CRISPR and Genetic Engineering
- Ovarian function and disorders
- Cancer-related molecular mechanisms research
- Animal Nutrition and Physiology
- Pancreatitis Pathology and Treatment
- Animal Behavior and Welfare Studies
- Human-Animal Interaction Studies
- Reproductive System and Pregnancy
- Plant and fungal interactions
- Study of Mite Species
- Genomics and Chromatin Dynamics
- Nail Diseases and Treatments
- Bird parasitology and diseases
- Rabies epidemiology and control
- RNA Research and Splicing
- Ruminant Nutrition and Digestive Physiology
- Animal Disease Management and Epidemiology
- Virus-based gene therapy research
- Fungal Biology and Applications
Rural Development Administration
2018-2025
National Institute of Animal Science
2012-2025
Gyeongsang National University
2024
Chungnam National University Hospital
2023
Chungnam National University
2023
University of California, Los Angeles
1999-2016
Gyeongnam National University of Science and Technology
2009-2012
VA Greater Los Angeles Healthcare System
1999-2002
Abstract There is increasing evidence that food‐derived polyphenols have a beneficial effect for cancers. Our purpose was to determine the and mechanism of action these compounds on pancreatic cancer. We measured effects quercetin cancer in nude mouse model. also investigated quercetin, rutin, trans‐resveratrol genistein apoptosis underlying signaling carcinoma cells vitro . Quercetin decreased primary tumor growth, increased prevented metastasis model In trans‐resveratrol, but not markedly...
Pathogenesis studies of SIV infection have not been performed to date in wild monkeys due difficulty collecting and storing samples on site the lack analytical reagents covering extensive diversity. We a large scale study molecular epidemiology natural history SIVagm 225 free-ranging AGMs from multiple locations South Africa. prevalence (established by sequencing pol, env, gag) varied dramatically between infant/juvenile (7%) adult animals (68%) (p<0.0001), females (78%) males (57%)....
Apoptosis and necrosis are critical parameters of pancreatitis, the mechanisms which remain unknown. Many characteristics pancreatitis can be studied in vitro pancreatic acini treated with high doses cholecystokinin (CCK). We show here that CCK stimulates apoptosis death signaling pathways rat acinar cells, including caspase activation, cytochromec release, mitochondrial depolarization. The dysfunction is mediated by upstream caspases (possibly caspase-8) and, turn, leads to activation...
African green monkeys (AGMs) are naturally infected with simian immunodeficiency virus (SIV) at high prevalence levels and do not progress to AIDS. Sexual transmission is the main route in AGM, while mother-to-infant (MTIT) negligible. We investigated SIV wild AGMs assess whether or due differences mucosal permissivity (i.e., genetic bottleneck of viral reported humans macaques also observed wild). tested 121 sabaeus (Chlorocebus sabaeus) from Gambia found that 53 were (44%). By combining...
We report here the first genome-wide high-resolution polymorphism resource for non-human primate (NHP) association and linkage studies, constructed Caribbean-origin vervet monkey, or African green monkey (Chlorocebus aethiops sabaeus), one of most widely used NHPs in biomedical research. generated this by whole genome sequencing (WGS) monkeys from Vervet Research Colony (VRC), an NIH-supported research which extensive phenotypic data are available.We identified single nucleotide...
Non-human primates provide genetic model systems biologically intermediate between humans and other mammalian organisms. Populations of Caribbean vervet monkeys (Chlorocebus aethiops sabaeus) are genetically homogeneous large enough to permit well-powered mapping studies quantitative traits relevant human health, including expression trait loci (eQTL). Previous transcriptome-wide investigation in an extended pedigree identified 29 heritable transcripts for which levels peripheral blood...
Age and breed are considered the greatest risk factors for disease prevalence mortality in companion dogs. Understanding of diseases, relation to age breed, would support appropriate guidance future health care strategies provide useful information early diagnosis diseases. The purpose this study was investigate major medical causes dogs visiting primary-care veterinary clinics Republic Korea, stratified by breed.A total 15,531 records canine patients were analyzed from 11 who shared data...
Yeonsan Ogye (YO), an indigenous Korean chicken breed (Gallus gallus domesticus), has entirely black external features and internal organs. In this study, the draft genome of YO was assembled using a hybrid de novo assembly method that takes advantage high-depth Illumina short reads (376.6X) low-depth Pacific Biosciences (PacBio) long (9.7X).
Abstract Trichophyton verrucosum causes a highly contagious disease in bovines and is occasionally transmitted to humans. Azoles are widely used as antifungal drugs bovines, act by targeting the ergosterol biosynthesis pathway. However, cases of treatment failure recurrence dermatophyte infections have been associated with mutations at drug target site. Currently, information on T. variants lacking. This study aimed classify isolated from animals exhibiting clinical symptoms cattle...
This study aimed to evaluate the efficacy of Lactiplantibacillus argentoratensis AGMB00912 (LA) in reducing Salmonella Typhimurium infection weaned piglets. The investigation focused on influence LA gut microbiota composition, growth performance, and fecal shedding. results indicated that supplementation significantly improved average daily gain reduced prevalence severity diarrhea. Fecal analysis revealed shedding LA-supplemented group. Furthermore, notably altered composition microbiota,...
African swine fever (ASF), caused by virus (ASFV), is a fatal disease affecting wild and domestic pigs. Since China reported the first ASF outbreak in August 2018, ASFV has swept over neighbouring Asian countries. However, studies involving experimental pig-to-pig transmission Vietnam are lacking. The main objective of this study was to demonstrate pathobiological characteristics contact-exposed pigs estimate their basic reproduction number (R0) Vietnam. Fifteen were randomly divided into...
Rumen cannulation is a surgical technique used to collect rumen contents from ruminants. However, surgery may potentially impact the composition of microbiota. This study aimed examine longitudinal alterations in microbiota Hanwoo steers after surgery. In this study, eight were used; four underwent (cannulation group), while remaining left intact (control group). samples collected all using stomach tubing method on day before (day 0) and postoperative days 1, 4, 7, 10, 14, 17, 21, 24, 28,...
Exosomes have been extensively studied as disease biomarker in humans, given their role transporting bioactive molecules. However, despite the great potential of exosomes noninvasive diagnostic markers and therapeutic nanocarriers for bovine diseases, few studies conducted on exosome. Thus, this study aimed to quantitatively qualitatively compare three isolation methods identify a suitable method serum. were isolated using ultracentrifugation alone (UC), combination size exclusion...
Data collected by the National Livestock Research Institute of Rural Development Administration Korea were used to estimate genetic parameters for yearling (YWT, n = 5,848), 18-mo (W18, 4,585), and slaughter (SWT, 2,279) weights Korean Native cattle. Nine animal models obtain REML estimates parameters: DP-2 included genetic, uncorrelated dam, residual random effects; DQ-2 sire x region year-season interaction, DPQ-2 was based on but both interaction dam DMP-2 with effect partitioned include...
The objective of this study was to evaluate the effect spent mushroom substrate (SMS) derived from Pleurotus eryngii on hematological and biochemical blood properties elk. A total 18, two three-year-old elk were fed three different levels SMS (0, 15 20%) in a corn-wheat bran diet for 80 days. results indicated significantly high monocytes, hemoglobin (Hb), hematocrit (HCT) 15% or 20% (p<0.05) compared control animals. Serum urea nitrogen (BUN) glucose concentrations also elevated both SMS....
Careful cleaning and disinfection of pigpens is essential to prevent disease spread avoid the resultant economic losses. Hygiene in generally evaluated by visual monitoring supplemented with bacteriological monitoring, which includes counting total aerobic bacteria (TAB) and/or fecal indicator (FIB). However, these methods present drawbacks such as time labor requirements. As adenosine triphosphate (ATP) ubiquitous all living organisms including microorganisms, this study aimed directly...
Myxomatous mitral valve disease (MMVD) is the most common cardiovascular disorder in dogs with a high prevalence, accounting for approximately 75% of all canine heart cases. MMVD complex and shows variable progression from mild leakage to severe regurgitation, potentially leading failure. However, molecular mechanisms age-related changes that govern progression, especially at early stage (B1) before development discernable clinical signs, remain poorly understood. In this prospective study,...
Salmonella enterica serovar Typhimurium (ST) is one of the causative agents gastroenteritis in pigs. Pigs fed a diet supplemented with raw potato starch (RPS) have improved gut health by alteration microbiota composition and production short-chain fatty acids (SCFAs). This study aimed to evaluate effects RPS supplementation reducing infection severity fecal shedding ST-infected pigs.The weaned experimental pigs were divided into two groups: CON (n = 6) corn/soybean-based TRT 5% RPS. After 21...