A5100392461- Physiological and biochemical adaptations
- Aquaculture Nutrition and Growth
- Fish Ecology and Management Studies
- Water Treatment and Disinfection
- Mercury impact and mitigation studies
- CAR-T cell therapy research
- Renal and related cancers
- Marine animal studies overview
- Reproductive biology and impacts on aquatic species
- Radioactive contamination and transfer
- Oceanographic and Atmospheric Processes
- Radioactive element chemistry and processing
- Zebrafish Biomedical Research Applications
- Ocean Waves and Remote Sensing
- Sarcoma Diagnosis and Treatment
- Radioactivity and Radon Measurements
- Tropical and Extratropical Cyclones Research
- Constructed Wetlands for Wastewater Treatment
- Vascular Malformations and Hemangiomas
- Viral Infectious Diseases and Gene Expression in Insects
- Coagulation and Flocculation Studies
- Melanoma and MAPK Pathways
- Medical Research and Treatments
- Traditional Chinese Medicine Analysis
- Congenital heart defects research
University of Washington
2021-2024
Washington School of Psychiatry
2024
University of Miami
1991-2023
Xi'an University of Architecture and Technology
2023
Dalian University
2022
Guangzhou University of Chinese Medicine
2022
Capital University
2021
Capital Medical University
2021
Ocean University of China
2018-2021
Henan Provincial Center for Disease Control and Prevention
2020
We document the long-term evolution of an Agulhas ring detected from satellite altimetry using a technique nonlinear dynamical systems that enables objective (i.e., observer-independent) eddy framing. Such objectively eddies have Lagrangian (material) boundaries remain coherent (unfilamented) over detection period. The preserves quite compact material entity for period about 2 years even after most initial coherence is lost within 5 months detection. attribute this to successive development...
Abstract The four human glycoprotein hormones are heterodimers that contain a common alpha subunit and hormone-specific beta subunit. Within this hormone family, 23 amino acid sequences from 11 mammalian species available. There 19 invariant residues in the subunits, 12 of which Cys form six disulfide bonds. Of remaining seven conserved residues, we have investigated role an Asp occurs at position 99 choriogonadotropin (hCG beta). Site-directed mutagenesis was used to replace hCG Asp99 with...
Freshwater- and seawater-acclimated Fundulus heteroclitus were exposed to acute hypoxia (10% air saturation, 3h), followed by normoxic recovery (3h). In both salinities, ventilation increased heart rate fell in the classic manner, while MO2 initially declined ∼50%, with partial restoration 3h of hypoxia, no O2 debt repayment during recovery. Gill paracellular permeability (measured [14C] PEG-4000) was 1.4-fold higher seawater, 50% post-exposure overshoot 188%. A similar pattern smaller...
In light of growing concerns about the formation nitrogen-based disinfection byproducts (N-DBP) and possible contribution from use quaternary-ammonium-containing flocculants, there is interest in alternative quaternary phosphonium salts, which have been reported to a lower DBP potential, stronger cationic properties, cytotoxicity, greater stability. this study, performance N-free quaternary-phosphonium-modified starch flocculants (S-BTP), synthesized through facile one-step method using...
Radial spokes are structurally conserved, macromolecular complexes that essential for the motility of 9 + 2 motile cilia. In Chlamydomonas species, mutations in radial spoke proteins result ciliary defects. However, little is known about function during embryonic development. Here, we investigated role a novel protein, leucine-rich repeat containing protein 23 (Lrrc23), zebrafish Mutations lrrc23 resulted selective otolith formation defect early ear Similar defects were also present head 3...
Abstract Aquaporins are the predominant water‐transporting proteins in vertebrates, but only a handful of studies have investigated aquaporin function fish, particularly mediating water permeability during salinity challenges. Even less is known about hypoxia (low oxygen), which can profoundly affect gill function. Fish deprived oxygen typically enlarge surface area and shrink water‐to‐blood diffusion distance, to facilitate uptake into bloodstream. However, these alterations morphology...
Mahi-mahi (Coryphaena hippurus) is a commercially and ecologically important fish species that widely distributed in tropical subtropical waters. Biological attributes reproductive capacities of mahi-mahi make it tractable model for experimental studies. In this study, life development cultured from the zygote stage to adult has been described.A comprehensive developmental table created reporting as primarily detailed observations morphology. Additionally, physiological, behavioral,...
A thin-layer source for the counting of polonium isotopes by alpha spectrometry can be rapidly prepared using microprecipitation with tellurium. Polonium was first coprecipitated reduction tellurium stannous chloride, followed microfiltration onto a membrane filter counting. This method is faster, cheaper, and more convenient than traditional spontaneous deposition method, an excellent Po recovery (>90%) under optimal conditions. The influences several experimental parameters, including...
Cilia are microtubule-based structures projecting from the cell surface that perform diverse biological functions. Ciliary defects can cause a wide range of genetic disorders known collectively as ciliopathies. Intraflagellar transport (IFT) proteins essential for assembly and maintenance cilia by transporting along axoneme. Here, we report lack Ift74, core IFT-B protein, leading to ciliogenesis in multiple organs during early zebrafish development. Unlike rapid photoreceptor death other...
To investigate a novel diagnostic model for benign and malignant pulmonary nodule diagnosis based on radiomic clinical features, including urine energy metabolism index.A total of 107 nodules were prospectively recruited pathologically confirmed as in 86 cases 21 cases. A chest CT scan test performed all nomogram was established combination with levels. The compared the feature alone to its validity, receiver operating characteristic (ROC) curves plotted assess validity.The using logistic...
Rhabdomyosarcoma (RMS) is a pediatric soft tissue sarcoma that causes significant devastation, with no effective therapy for relapsed disease. The mechanisms behind treatment failures are poorly understood. Our study showed of RMS cells vincristine led to an increase in CD133-positive stem-like resistant cells. Single cell RNAseq analysis revealed MYC and YBX1 were among the top-scoring transcription factors CD133-high expressing Targeting using CRISPR/Cas9 reduced characteristics viability...
Estuarine crocodiles,
Abstract Rhabdomyosarcoma (RMS) is a devastating pediatric cancer. There has not been any significant change in the treatment options for last 4 decades, especially relapsed or advanced disease. an urgent need to identify alternative improve survival outcomes of RMS patients. comprised two major subtypes as defined by presence absence PAX3/PAX7-FOXO1 gene fusion. Fusion-negative (FN RMS) characterized alterations RAS-PI3K-MAPK pathway >90% cases. However, role PI3K-MAPK therapy...