Lei Xu

ORCID: 0000-0003-3213-2924
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About
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Research Areas
  • Lung Cancer Diagnosis and Treatment
  • Ruminant Nutrition and Digestive Physiology
  • Esophageal and GI Pathology
  • Soil Carbon and Nitrogen Dynamics
  • Esophageal Cancer Research and Treatment
  • Pleural and Pulmonary Diseases
  • Rice Cultivation and Yield Improvement
  • Gut microbiota and health
  • Lung Cancer Treatments and Mutations
  • Gastric Cancer Management and Outcomes
  • Medical Imaging and Pathology Studies
  • Reproductive Physiology in Livestock
  • Plant nutrient uptake and metabolism
  • Soil and Water Nutrient Dynamics
  • Probiotics and Fermented Foods
  • Legume Nitrogen Fixing Symbiosis
  • Nutrition and Health in Aging
  • Genetic and phenotypic traits in livestock
  • Climate change impacts on agriculture
  • Pelvic and Acetabular Injuries
  • Crop Yield and Soil Fertility
  • Frailty in Older Adults
  • Cardiac, Anesthesia and Surgical Outcomes
  • Animal health and immunology
  • Mycorrhizal Fungi and Plant Interactions

Chinese Academy of Medical Sciences & Peking Union Medical College
2020-2025

Chinese Academy of Agricultural Sciences
2022-2024

Institute of Animal Sciences
2024

Hubei University of Medicine
2024

Nanjing Agricultural University
2011-2024

State Key Laboratory of Food Science and Technology
2023-2024

Institute of Grassland Research
2024

Lanzhou University
2024

Ministry of Agriculture and Rural Affairs
2024

Chengdu Women's and Children's Central Hospital
2024

Straw incorporation is a global common practice to improve soil fertility and rice yield. However, the effect of straw on yield stability still unknown, especially under high fertilization level conditions. Here, we reported returning levels in rice–wheat system over nine years. The results showed that did not significantly affect average reduced coefficient variation by 25.8% increased sustainable index 8.2%. positively correlated with mean photosynthetically active radiation (PAR) growth...

10.1016/j.cj.2020.11.007 article EN cc-by-nc-nd The Crop Journal 2021-01-12

This study investigated the dynamic shifts in mucosa-associated microbiota composition and mucosal morphology colon of sheep fed a high grain (HG) diet. A total 20 male were randomly assigned to 4 groups (n = 5 for each). The first group received hay animals other 3 an HG diet 7 (HG7), 14(HG14) or 28 (HG28) days, respectively. Colonic digesta samples collected determine pH concentrations volatile fatty acid (VFA) lactate. colonic mucosa was sampled characterize bacterial communities using...

10.3389/fmicb.2017.02080 article EN cc-by Frontiers in Microbiology 2017-10-26

Abstract Background Fermented foods are considered to be beneficial for human health. Secondary metabolites determined by biosynthetic gene clusters (BGCs) precious bioactive compounds with various biological activities. However, the diversity and distribution of potential secondary in global food fermentations remain largely unknown. In this study, we performed a large-scale comprehensive investigation BGCs metagenomics analysis. Results We recovered 653 bacterial metagenome-assembled...

10.1186/s40168-023-01536-8 article EN cc-by Microbiome 2023-05-20

// Junfei Guo 1 , Guangjun Chang Kai Zhang Lei Xu Di Jin Muhammad Shahid Bilal and Xiangzhen Shen College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, P.R. China Correspondence to: Shen, email: Keywords : subacute ruminal acidosis, lipopolysaccharide, inflammatory injury, liver, dairy cows,  Immunology Microbiology Section, Immune response, Immunity Received January 09, 2017 Accepted May 11, Published 24, Abstract Rumen-derived lipopolysaccharide (LPS) is...

10.18632/oncotarget.18151 article EN Oncotarget 2017-05-24

Dairy cows are often fed a high-concentrate diet to meet lactating demands, yet long-term concentrate feeding induces subacute ruminal acidosis (SARA) and leads decrease in milk fat. Stearoyl-CoA desaturase1 (SCD1) participates fatty acid biosynthesis the liver of ruminants. Here, we conducted this study investigate impact lipopolysaccharide derived from rumen on SCD1 expression composition dairy diet. Eight multiparous mid-lactating Holstein (455 ± 28 kg) were randomly assigned into two...

10.1186/s12917-015-0360-6 article EN cc-by BMC Veterinary Research 2015-03-06

To meet the nutrition requirements of lactation, dairy cows are usually fed a high concentrate diet (HC). However, high-grain feeding causes subacute ruminal acidosis (SARA), metabolic disorder that milk protein depression. This study aimed to investigate effect lipopolysaccharide (LPS) released in rumen on inflammatory gene expression and casein synthesis mammary glands lactating HC diet. We found was significantly decreased group after 15 weeks feeding. Overall, LPS concentrations fluid,...

10.18632/oncotarget.7371 article EN Oncotarget 2016-02-13

Subacute ruminal acidosis (SARA) is a metabolic disorder in dairy cows that associated with dysbiosis of rumen and hindgut microbiomes, translocation immunogenic compounds from the gut lumen into blood circulation, systemic inflammatory response. In this study we hypothesized Saccharomyces cerevisiae fermentation products (SCFP) attenuate increases peripheral bacterial endotoxin concentrations inflammation resulting repeated induction SARA. Lactating Holstein (parity 2 3+, n = 32) were fed...

10.3168/jds.2021-20572 article EN cc-by Journal of Dairy Science 2022-01-05

Abstract Background Lipoxygenase (LOX) is a multifunctional enzyme that primarily related to plant organ growth and development, biotic abiotic stress responses, production of flavor-associated metabolites. In higher plants, the LOX family encompasses several isozymes with varying expression patterns between tissues developmental stages. These affect processes including seed germination, storage, seedling growth, fruit ripening, leaf senescence. genes have multiple functions in response...

10.1186/s12864-024-10071-1 article EN cc-by BMC Genomics 2024-02-19

ABSTRACT Objectives This study aimed to analyze lymph node metastasis (LNM) distribution in superficial esophageal squamous cell carcinoma (ESCC) and its impact factors on survival. Methods We reviewed 241 pT1N+ ESCC cases between February 2012 April 2022 from 10 Chinese hospitals with a high volume of cancer (EC). analyzed clinicopathological data identify overall survival (OS) risk LNM relation tumor invasion depth. Results Of the patients, 26 (10.8%) had pT1a 215 (89.2%) pT1b cancer....

10.1111/1759-7714.15504 article EN cc-by-nc-nd Thoracic Cancer 2025-01-01

Background Percutaneous kyphoplasty (PKP) is a common treatment modality for painful osteoporotic vertebral compression fractures (OVCFs). Pre- and postoperative identification of risk factors cement leakage follow-up complications would therefore be helpful but has not been systematically investigated. Purpose To evaluate pre- the occurrence short-term leakages long-term after PKP OVCFs. Material Methods A total 283 vertebrae with in 239 patients were Possible causing during periods...

10.1177/0284185117725368 article EN Acta Radiologica 2017-08-07

The cecum serves as an additional fermentation site for ruminants, but it lacks buffering capacity and has a relatively simple epithelial structure compared to the rumen. role of high-grain (HG) diets in manipulating rumen microbiome been well elucidated, yet microbial response such subsequent microbe-host interactions remain largely unexplored. Here, we describe modification cecal host gene expression based on data from 20 sheep grouped feed HG diet 7, 14, 28 days. Our indicate that...

10.1128/msystems.00915-21 article EN mSystems 2021-10-05

The rapid shift to high-grain (HG) diets in ruminants can affect the function of rumen epithelium, but dynamic changes composition epithelium-associated (epimural) bacterial community sheep still needs further investigation. Twenty male lambs were randomly allocated four groups (n = 5). Animals first group received hay diet and represented a control (CON). Simultaneously, animals other three (HG groups) rapidly shifted an HG (60% concentrate)which continued for 7 (HG7), 14 (HG14) 28 (HG28)...

10.1017/s1751731118003269 article EN cc-by-nc-nd animal 2018-12-18

The aim of this study was to evaluate the efficacy mindfulness-based stress reduction (MBSR) on health-related quality life (QoL), depression, and anxiety in patients with differentiated thyroid cancer (DTC) receiving radioactive iodine therapy (RIT).A randomized controlled trial MBSR 120 DTC performed. They were randomly assigned into intervention group usual care (UC) group. An 8-week program administered starting 8 weeks before RIT. Health-related QoL, measured immediately start (T1),...

10.2147/cmar.s183299 article EN cc-by-nc Cancer Management and Research 2019-01-01

Nitrogen (N) fertilization increases rice yield, but inappropriate N fertilizer application loss and the risk of environmental pollution. Short-term postponing (FP) generally reduces apparent surplus yields, effects long-term FP on yields remain unknown. Our study was first to investigate impacts (11 years) yields. in short term (≤6 did not affect whereas long (>6 increased by 13.9% compared with conventional (CF). panicles per unit area, 1000-kernel weight, filled-kernel rate, spikelets...

10.1016/j.cj.2022.01.001 article EN cc-by-nc-nd The Crop Journal 2022-03-01
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