A5050858841- Immune Cell Function and Interaction
- Immune cells in cancer
- Head and Neck Cancer Studies
- Salivary Gland Tumors Diagnosis and Treatment
- Single-cell and spatial transcriptomics
- Cancer Immunotherapy and Biomarkers
- Metabolomics and Mass Spectrometry Studies
- Ferroptosis and cancer prognosis
- Calcium signaling and nucleotide metabolism
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Pancreatic and Hepatic Oncology Research
- Cancer Genomics and Diagnostics
- Liver Disease Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Cancer, Lipids, and Metabolism
- IL-33, ST2, and ILC Pathways
- Arsenic contamination and mitigation
- Selenium in Biological Systems
- PARP inhibition in cancer therapy
- Adenosine and Purinergic Signaling
- High Altitude and Hypoxia
- Molecular Biology Techniques and Applications
- Fluoride Effects and Removal
- Gene expression and cancer classification
- Cancer-related molecular mechanisms research
Peking University
2021-2024
Peking University Shenzhen Hospital
2021-2024
Center for Life Sciences
2021
Beihang University
2020
Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers, characterized by rapid progression, metastasis, and difficulty in diagnosis. However, there are no effective liquid-based testing methods available for PDAC detection. Here we introduce a minimally invasive approach that uses machine learning (ML) lipidomics to detect PDAC. Through greedy algorithm mass spectrum feature selection, optimized 17 characteristic metabolites as detection features developed liquid...
Abstract Background Nonkeratinizing nasopharyngeal carcinoma (NK-NPC) has a strong association with Epstein-Barr virus (EBV) infection. The role of NK cells and the tumor cell evolutionary trajectory in NK-NPC remain unclear. In this study, we aim to investigate function by single-cell transcriptomic analysis, proteomics immunohistochemistry. Methods (n = 3) normal mucosa cases were collected for proteomic analysis. Single-cell data 10) lymphatic hyperplasia (NLH, n obtained from Gene...
Background: Chronic obstructive pulmonary disease (COPD) is a common characterized by persistent respiratory symptoms and airflow restriction. It usually manifested as airway and/or alveolar abnormalities caused significant exposure to harmful particulates or gases. Objective: We aim explore plasma metabolomic changes in the acute exacerbation stage of COPD (AECOPD) stable (Stable COPD) identify potential biomarkers for diagnosis prognosis clinical practice. Methods: Untargeted metabolomics...
Antimony (Sb) poses a significant threat to human health due sharp increases in its exploitation and application globally, but few studies have explored the pathophysiological mechanisms of acute hepatotoxicity induced by Sb exposure. We established an vivo model comprehensively explore endogenous underlying liver injury short-term Adult female male Sprague-Dawley rats were orally administrated various concentrations potassium antimony tartrate for 28 days. After exposure, serum...
Early identification and therapy can significantly improve the outcome for gastric cancer. However, there is still no perfect biomarker available detection of early This study aimed to investigate alterations in plasma metabolites cancer using metabolomics lipidomics based on high-performance liquid chromatography-mass spectrometry (HPLC-MS), which detected potential biomarkers that could be used clinical diagnosis.
Abstract Background Nonkeratinizing nasopharyngeal carcinoma (NK-NPC) has a strong association with Epstein-Barr virus (EBV) infection. The role of NK cells and the tumor cell evolutionary trajectory in NK-NPC remain unclear. In this study, we aim to investigate function by single-cell transcriptomic analysis, proteomics immunohistochemistry. Methods (n=3) normal mucosa cases were collected for proteomic analysis. Single-cell data obtained from Gene Expression Omnibus (GSE162025). Quality...
Abstract The depletion of NAD is intimately linked to neurodegenerative diseases and aging. Excessive activation + -consuming enzymes that hydrolyze ADP-ribose nicotinamide closely related diseases. However, supplementation or its precursors failed show any benefits for most patients. molecular mechanisms underlying this are largely undefined. Here we ADP-ribose, as an endogenous metabolite, triggers neuronal cell death by glutathione-independent ferroptosis. cells in both the hippocampus...