Abstract Background Curcumin has been demonstrated to exert anti-oxidant, anti-fibrotic, anti-inflammatory, and anti-cancer activities. This study was conducted observe the effect inner mechanism of curcumin in rats with radiation-induced liver damage (RILD). Methods Thirty SD were classified into Control, Radiation group (Cur) + ( n = 10 each group). The changes body weight observed on 3rd, 7th 14th days after treatment curcumin. On day post treatment, heart blood drawn for measurement...

Sirtuin 7 (SIRT7) is a NAD+-dependent deacetylase in the sirtuin family. In previous study, human bone marrow mesenchymal stem cells (hBMSCs) with reduced SIRT7 activity were developed to evaluate effect of on osteogenesis. knockdown significantly enhanced osteoblast-specific gene expression, alkaline phosphatase activity, and mineral deposition vitro. Additionally, upregulated β-catenin. The osteogenesis due was partially rescued by Wnt/β-catenin inhibitor. Furthermore, hBMSCs combined...

Treatment of the high-risk triple negative breast cancer (TNBC) is a critical clinical challenge. Here we aimed to explore novel strategy for TNBC treatment by blocking tumor-associated chemokine CXCL13 in MDA-MB-231 cells.MDA-MB-231 cells were treated with anti-CXCL13 antibodies (inhibition group), or phosphate-buffered saline (PBS) (control followed determining levels interleukin-1 (IL-1), tumor necrosis factor-alpha (TNF-α) and transforming growth factor beta-1 (TGF-β1) enzyme-linked...

Bone regeneration is a popular research focus around the world. Recent studies have suggested that formation of vascular network as well intrinsic osteogenic ability important for bone regeneration. Here, we show first time matrix metalloproteinase (MMP) 2 inhibitor 1 (MMP2-I1) has positive role in osteogenesis human marrow mesenchymal stem cells (hBMSCs) and angiogenesis endothelial (HUVECs). MMP2-I1 activated p38/mitogen-activated protein kinase signaling pathway to promote hBMSCs,...

Background. The combined occurrence of ACL rupture with a posterolateral tibial plateau fracture has not yet been reported. Two cases such injuries have treated in our department for the past three years. Findings. two patients both suffered from traffic accidents. radiological examinations showed ruptured plateau. Reconstruction was performed via standard anatomical single bundle reconstruction technique autologous tendon by arthroscopy. A tibia approach used to reduce and fix fractured...

Objective Polyvinylpyrrolidone (PVP) is a commonly used biomedical polymer material with good water solubility, biocompatibility, low immunogenicity, and toxicity. The aim of this study to investigate the antioxidant mechanism clinical potential PVP modified selenium nanoparticles (PVP-Se NPs) as new radioprotective agent. Methods A laser particle size analyzer transmission electron microscope were characterize PVP-Se prepared by chemical reduction. Human umbilical vein endothelial cells...

The aim of this study was to evaluate our treatment algorithm and results in revision surgery malunited tibial plateau fracture after failure initial treatment.Our strategy as follows: First, we determined the presence any infection. Second, whether patient required total knee arthroplasty (TKA). Third, based on characteristics malunion, patients underwent one following surgical methods achieve reduction: original line osteotomy, tubercle + fibula head metaphyseal open window reduction rod...

Our hospital has recently used the extended anterolateral approach in posterolateral tibial plateau fracture. We compared clinical effects of this method Schatzker type II or V/VI fractures with fracture based on our patients. The patients from January 2013 to December 2015 were summarized, and some them assisted arthroscopy. According classification, divided into group A; B. characteristics, operation statistics, postoperative functional evaluation each compared. A total 46 included study...

Background Augmentation plating has been used successfully to treat hypertrophic non-union after nail fixation. This study compared the efficacy of augmentation and exchange for treating femoral shaft fracture intramedullary Methods A total 12 patients received 15 as treatment non-union. The procedures were conducted at our medical centre between January 2005 2012. Clinical follow-up was 2 weeks, 1 month then monthly until union achieved compare time, operation bleeding complications two...

Abstract Background To explore the epidemiological characteristics, clinical treatment strategies, and results of non-dislocated hyperextension tibial plateau fracture. Method A total 25 cases fracture patients were collected (12 males 13 females), aged 27–79 years. Preoperative posterior slope angle was − 10~0° (average 5.2°). MRI showed 5 MCL injury, 3 PLC complex 2 + PCL injury. The change more than 10° in with ligament a less had no injury; 6 simple column bilateral three Results...

Objectives Three‐dimensional (3D) printing technology has shown potential advantages in accurate and efficient tibial plateau fracture (TPF) treatment. This can provide structural morphology to repair fragments. Here, we summarize our experience with the use of 3D during intraarticular osteotomy treatment malunion TPF. Methods The patients who were treated TPF hospital between January 2015 December 2018 retrospectively analyzed. These divided into two groups: conventional group without...

Abstract The IGF signaling pathway plays critical role in regulating skeletal myogenesis. We have demonstrated that KIF5B, the heavy chain of kinesin‐1 motor, promotes myoblast differentiation through IGF‐p38MAPK activation. However, roles kinesin light (Klc) and remain elusive. In this study, we found Klc1 was upregulated during muscle regeneration downregulated senescence mouse muscles dystrophic from mdx (X‐linked muscular dystrophic) mice. Gain‐ loss‐of‐function experiments further...

This study aims to investigate the biocompatibility and pharmacokinetic characteristics of polyvinyl pyrrolidone-modified selenium nanoparticles (PVP-Se NPs). Understanding biosafety PVP-Se NPs is crucial due their potential applications in mitigating oxidative stress-related diseases improving drug delivery systems. Selenium were prepared using a sodium selenite solution, followed by PVP modification. Particle size analysis was conducted dynamic light scattering (DLS), particle morphology...

Objective To investigate the injury mechanism, fracture characteristics, treatment strategy and prognosis of Pilon without fibula fracture. Methods 28 cases (29 fractures) treated in our hospital were adapted from January 2009 to December 2014. 22 male, 6 female, aged 46 years old (23-75). Cause injury: tumble 14 cases, fall high place 8 traffic accident 5 bruise 1 case. 10 had associated injuries, 2 open injuries. The OA/ATO type, Ruedi & Allgower characteristics fractures...

To verify the accuracy and effectiveness of Goldengate high-throughput deafness gene chip in detecting patients with enlarged vestibular aqueduct syndrome(EVAS), to provide a reference for genetic detection strategy EVAS.

The present study aimed to investigate the association of invasiveness colon cancer (CC) with expression CCAAT/enhancer binding protein α (C/EBPα). Immunohistochemistry was performed determine C/EBPα in and adjacent tissue samples from 48 patients CC. A pCDGFP-C/EBPα eukaryotic vector constructed, a wound-healing assay observe effect transfection on migration SW480 cells. In addition, levels tumor invasion-associated proteins, including Kruppel-like factor 5 (KLF5), matrix metallopeptidase...

Objective To study the clinical and electrophysiological features of patients with hereditary neuropathy liability to pressure palsy (HNPP) diagnosed by gene analysis. Methods Seven from two HNPP families were assessed on medical history, physical examination, electrophysiology findings analysis. Results A manifestation acute, painless, recurrent peripheral nerve palsies was typical for HNPP. Median, ulnar peroneal nerves usually affected. Electrophysiology revealed that...

Objective To investigate the therapeutic effects of early enteral nutrition by gastroscopeguided naso-jejunal feeding tube placement on intestinal endotoxemia patient with severe acute pancreatitis (SAP).Methods Fourty-three patients were randomized into two groups:patients receiving (EN) gastroscope-guided (24 cases) and those total parenteral (TPN) ( 19 cases).The serum endotoxin(ET),albumin (ALB) amylase (AMY) levels measured.Abdominal distension other complications observed in...

To compare the diagnostic value of high-resolution uhrasonography (HR-US) with nerve conduction study (NCS) in patients clinically defined carpal tunnel syndrome (CTS),a prospective was conducted on 37 consecutive investigated for sensory hand symptoms. With clinical diagnosis CTS as gold standard,NCS showed higher sensitivity (80％) than ultrasound (61％) (P =0.047 ).The positive predictive HR-US 100％.The results indicated that could be used a screening method majority suspected and only...