A5002051230- Veterinary Oncology Research
- Periodontal Regeneration and Treatments
- Mesenchymal stem cell research
- Oral and Maxillofacial Pathology
- dental development and anomalies
- Osteoarthritis Treatment and Mechanisms
- Wound Healing and Treatments
- Temporomandibular Joint Disorders
- Electrospun Nanofibers in Biomedical Applications
- Immunotherapy and Immune Responses
- T-cell and B-cell Immunology
- Salivary Gland Tumors Diagnosis and Treatment
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- HIV Research and Treatment
- Orthopedic Infections and Treatments
- Advanced biosensing and bioanalysis techniques
- Virus-based gene therapy research
- Hedgehog Signaling Pathway Studies
- Oral and gingival health research
- Veterinary Orthopedics and Neurology
- Cardiac Arrest and Resuscitation
- Traumatic Brain Injury and Neurovascular Disturbances
- Cell Adhesion Molecules Research
- RNA Interference and Gene Delivery
- Herpesvirus Infections and Treatments
University of California, Davis
2016-2025
Veterinary Medical Teaching Hospital
2020-2023
Mesenchymal stem cells (MSCs) are a promising therapy for immune-mediated and inflammatory disorders, because of their potent immunomodulatory properties. In this study, we investigated the use fresh, autologous, adipose-derived MSCs (ASCs) feline chronic gingivostomatitis (FCGS), chronic, debilitating, idiopathic, oral mucosal disease. Nine cats with refractory FCGS were enrolled in pilot study. Each cat received 2 intravenous injections 20 million autologous ASCs, 1 month apart. Oral...
Tissue-engineered implants integrate with native tissue, are capable of adaptive remodeling, and improve healing temporomandibular joint disc defects in minipigs.
Abstract Mesenchymal stem cells (MSCs) have potent immunomodulatory functions and are a promising therapy for immune-mediated inflammatory disorders. We previously demonstrated the efficacy of fresh, autologous, adipose-derived MSCs (ASCs) to treat feline chronic gingivostomatitis (FCGS), oral mucosal disease similar human lichen planus. Here, we investigate use fresh allogeneic ASCs treatment FCGS in seven cats. Radiolabeled were also tracked systemically. Each cat received two intravenous...
Abstract Background The ability of mesenchymal stem cells (MSCs) to modulate immune responses inspired a series clinical trials addressing oral mucosal inflammation. We previously reported on the safety and efficacy fresh, allogeneic autologous, adipose-derived (ASCs) treat feline gingivostomatitis (FCGS), an inflammatory disease that shares similarities with human lichen planus. Methods To meet demand goals for future commercialization, we determined feasibility shipping fresh ASCs distant...
Objectives This study aimed to characterize the clinical, radiographic and histopathologic features of early-onset gingivitis (EOG) periodontitis in cats. Methods The medical records database was searched for cats diagnosed with histologically confirmed EOG or from 1997 2022. Information such as history, lifestyle factors, clinical presentation, were included 27 client-owned Response treatment long-term follow-up also recorded. Results Moderate-to-severe periodontal disease radiographically...
A multiorgan infection with a Coxiella-like organism was determined to be the cause of death female eclectus parrot( Eclectus roratus). The diagnosis based on gross lesions, histopathology, Gimenez and Gram special stains, immunohistochemistry, electron microscopy, polymerase chain reaction amplification sequencing bacterial 16s rRNA gene fragment isolated from hepatic cardiac tissue. Gross postmortem examination revealed multifocal coalescing foci necrosis. most significant histologic...
Frequent involvement of the disc in temporomandibular joint (TMJ) disorders warrants attempts to tissue engineer TMJ replacements. Physiologically, a great degree similarity is seen between humans and farm pigs (FPs), but pig's rapid growth confers significant challenge for vivo experiments. Minipigs have slower rate are smaller than FPs, minipig discs yet be fully characterized. The objective this study was determine suitability studies by extensive structural functional characterization....
Abstract ischemia-reperfusion injury (IRI) after hemorrhage is potentiated by aortic occlusion or resuscitative endovascular balloon of the aorta (REBOA). Given central role mitochondrial in shock, we hypothesized that Elamipretide, a peptide protects mitochondria, would mitigate IRI hemorrhagic shock and REBOA. Twelve pigs were subjected to 45 min After 25 REBOA, animals received either saline Elamipretide. Animals transfused with autologous blood during deflation, resuscitated isotonic...
Mesenchymal stromal cells (MSC) therapy has emerged as a potential treatment option for refractory FCGS. However, there is lack of long-term data on the use MSC in cats. This study aimed to evaluate safety and efficacy FCGS investigate factors associated with outcomes.This was retrospective evaluation 38 client-owned cats who received therapy. Medical records, histopathology, Stomatitis Activity Disease Index (SDAI) were reviewed. Correlations follow-up success rates SDAI cell line type used...
Feline chronic gingivostomatitis (FCGS) is an immune-mediated inflammatory condition affecting the oral mucosa that results in substantial pain and suffering. The goal of this study was to complete in-depth immunohistochemistry analysis affected FCGS mucosa, perform compare immune cell phenotypes blood healthy controls cats, determine a transcriptomic profile normal cats. We hypothesized cats with would have circulating activated CD8+ T cells tissues be infiltrated B highly proinflammatory...
The objective of this study is to describe the clinical features and computed tomography (CT) findings dogs with retrobulbar disease. There are two facets study: a retrospective case series in which primary versus secondary disease described, cross-sectional neoplasia infection/inflammation described compared. medical records 66 client-owned diagnosed between 2006 2016 were reviewed. Clinical information including signalment, specialty service dog was presented, signs, physical examination...
This study explored the feasibility of using fish skin bandages as a therapeutic option for third-degree burns. Following California wildfires, clinical observations animals with burns demonstrated increased comfort levels and reduced pain when treated tilapia skin. Despite promises this therapy, there are few studies explaining healing mechanisms behind application In study, mice were either hydrocolloid adhesive bandage (control) (n = 16) or 7 days post-burn. Mice subjected to histologic,...
Canine acanthomatous ameloblastomas (CAA), analogs of human ameloblastoma, are oral tumors odontogenic origin for which the genetic drivers have remained undefined. By whole-exome sequencing, we now discovered recurrent HRAS and BRAF activating mutations, respectively, in 63% 8% CAA. Notably, cell lines derived from CAA with mutation exhibit marked sensitivity to MAP kinase (MAPK) pathway inhibitors, constrain proliferation drive ameloblast differentiation. Our findings newly identify a...
Definitive ante mortem diagnosis of pancreatitis in horses is difficult. Reports summarising the most common clinical signs, clinicopathological features and concurrent disorders with a definitive that may aid recognition disease are lacking.To describe case details, data necropsy findings pancreatitis.This was retrospective study (1986-2011) inclusion criteria consisted pancreatitis. A medical records database search performed extracted included laboratory post findings. Pancreatitis...
Migration of cells from both local and systemic sources is essential for the inflammatory regenerative processes that occur during normal wound healing. CXCL12 considered a critical regulator CXCR4-positive cell migration tissue regeneration. In this study, we investigated expression Cxcl12 Cxcr4 healing murine full thickness ear wound. We also angiopoietin-like 4, which has been shown to participate in angiogenesis reepithelialization. At time points up 48hrs, complete blood counts were...