A5074659015- Veterinary Oncology Research
- Advanced Radiotherapy Techniques
- Head and Neck Surgical Oncology
- Medical Imaging Techniques and Applications
- Virus-based gene therapy research
- Bone Tumor Diagnosis and Treatments
- Glioma Diagnosis and Treatment
- Veterinary Medicine and Surgery
- Infectious Diseases and Mycology
- Cancer Diagnosis and Treatment
- Advanced MRI Techniques and Applications
- Sarcoma Diagnosis and Treatment
- Oral and Maxillofacial Pathology
- Microbial infections and disease research
- Cancer Cells and Metastasis
- Renal Transplantation Outcomes and Treatments
- Geochemistry and Geologic Mapping
- Magnetic Field Sensors Techniques
- Growth Hormone and Insulin-like Growth Factors
- Hematopoietic Stem Cell Transplantation
- Lung Cancer Diagnosis and Treatment
- Advanced X-ray and CT Imaging
- Veterinary Pharmacology and Anesthesia
- Nasal Surgery and Airway Studies
- Particle accelerators and beam dynamics
University of Wisconsin–Madison
2014-2024
Royal Rehabilitation Centre
2010
Background Cytotoxic chemotherapy can be very effective for the treatment of cancer but toxicity on normal tissues often limits patient tolerance and causes long-term adverse effects. The objective this study was to assist in preclinical development using modified, non-living bacterially-derived minicells deliver potent chemotherapeutic doxorubicin via epidermal growth factor receptor (EGFR) targeting. Specifically, sought evaluate safety efficacy EGFR targeted, loaded (designated...
To determine (1) the common types of canine splenic disorders, and breeds affected, that are diagnosed by cytopathological histopathological examination in Sydney, Australia (2) accuracy compared with for diagnosis disorders.69 51 diagnoses disorders presented to Veterinary Pathology Diagnostic Services, The University Sydney during 2006 2007 were tabulated analysed; 17 cases examined both cytopathologically histopathologically 2001-07 also analysed.The most benign growth, vascular...
Abstract Radiotherapy is the treatment of choice for non‐resectable canine thyroid carcinoma. High tumor response rates and median survival times 2 years or longer have been previously reported with conventionally fractionated hypofractionated protocols, even in dogs distant metastasis. The objective this retrospective, descriptive, case series study was to evaluate clinical outcomes carcinoma irradiated palliative intent using radiotherapy at our institution. Medical records 20 treated...
Contouring variability is a significant barrier to the accurate delivery and reporting of radiation therapy. The aim this descriptive study was determine variation in contouring targets organs at risk by participants within our institution. Further, we also aimed if all individuals contoured same normal tissues. Two canine nasal tumor datasets were selected two ACVR-certified oncologists oncology residents from Eight structures consistently including right left eye, lens, brain, gross volume...
With the improving energy resolution of transitionedge sensor (TES) based microcalorimeters, performance verification and calibration these detectors has become increasingly challenging, especially in range below 1 keV where fluorescent atomic X-ray lines have linewidths that are wider than detector require impractically high statistics to determine gain deconvolve instrumental profile. Better behaved sources such as grating monochromators too cumbersome for space missions difficult use lab....
The clinical features and interventional therapy in the case of a female cat with urinary tract obstruction secondary to neoplasia are presented. This form cats is rare therapeutic intervention relieve caused by malignancy has been described only once. first report self‐expandable metallic stent placed feline urethra use unique composite (Platinol™) cat. In conclusion, palliative stenting may be valid for malignancies. Further studies required determine optimal size type that will provide...
ViewRay is a novel MR-guided radiotherapy system capable of imaging in near real-time at four frames per second during treatment using 0.35T field strength. It allows for improved gating techniques and adaptive radiotherapy. Three cobalt-60 sources (~ 15,000 Curies) permit multiple-beam, intensity-modulated radiation therapy. The primary aim this study to assess the stability, accuracy, automatic segmentation algorithm capability track motion simulated vivo targets. Magnetic resonance (MRI)...
Abstract Dogs with sinonasal tumors cribriform plate lysis (modified Adams’ stage 4) treated non‐conformal definitive radiotherapy (RT) have short median survivals of 6‐7 months. Intensity‐modulated its greater conformality and tumor dose homogeneity may result in more favorable outcomes. epithelial or mesenchymal CT evidence that received 10 daily fractions 4.2 Gray using IMRT by helical tomotherapy were included this single‐institution retrospective case series study. distant metastasis,...
Abstract Radiotherapy plays an important role in curative and palliative cancer treatment. As a novel radiation delivery technique, stereotactic radiotherapy utilizes three‐dimensional‐conformal treatment planning, high‐precision beam technology, patient specific position verification to target tumors, often one five high‐dose fractions. Currently, there is no consensus about best practices veterinary radiotherapy. The objective of this study was document the breadth perspectives,...
Radiotherapy with or without surgery is a common choice for brain tumors in dogs. Although numerous studies have evaluated use of three-dimensional conformal radiotherapy, reports definitive-intent, IMRT canine intracranial are lacking. Intensity-modulated radiation therapy has the benefit decreasing dose to nearby organs at risk and may aid reducing toxicity. However, increasing conformity calls accurate target delineation daily patient positioning, order decrease geographic miss. To...
A terrella developed for the undergraduate Advanced Laboratory course in University of Wisconsin-Madison Physics Department is described. Our consists a permanent magnet, mounted on pedestal vacuum chamber, surrounded by electrodes that may be biased various ways. The system can confine plasma, which may, some ways, considered as toy model plasma confined Earth's magnetosphere. axisymmetric forms region where magnitude magnetic field B 14 G ≤B≤ 550 G; typical operation, neutral gas pressure...
Abstract OBJECTIVE To evaluate the in vivo spread of iodinated contrast following injections transversus abdominis plane (TAP) and rectus sheath anesthetized dogs via computed tomography. Secondarily, time performing each block was compared. ANIMALS 6 adult, purpose-bred Beagles. METHODS In a prospective crossover study, were administered either or fascial same manner as (RSB) TAP using dilute contrast. Computed tomography scans performed immediately injection (time [T]-0) at 3, 9, 18, 30...
This pilot study presents initial experience obtained with a real-time predictive motion tracking platform called Synchrony mounted on the Radixact radiotherapy device. treatments were offered as an alternative to surgical excision for primary pulmonary carcinomas well in dogs suspected oligometastatic disease state. All treated three fractions of 8 Gy. Six targets successfully treated, while we unable treat abdominal implanted fiducials. Cranial showed minimal movement, located adjacent...
Abstract A 10‐year‐old female spayed boxer was treated with stereotactic radiotherapy (SRT) for a suspected glioma in the left piriform lobe. The intra‐axial lesion T2 hyperintense, FLAIR T1 hypointense, and did not uptake contrast. Imaging performed an MRI every 3 months, at 6‐month recheck, new lesions hippocampus right lobe were evident without clinically apparent neurological progression. second course of SRT prescribed lesions. Euthanasia elected 14 months after first SRT, necropsy...
ABSTRACT The standard of care treatment for localised feline nasal lymphoma (FeNL) is radiation therapy (RT). Early local or systemic failure occurs in 17%–45% cats treated with RT without chemotherapy. aim this study was to determine if pre‐treatment biopsy characteristics could predict early tumour progression FeNL. Inclusion criteria consisted histologically confirmed FeNL, available paraffin blocks diagnostic quality, the sinonasal cavity on staging pre‐RT, IMRT/IGRT (10 × 4.2 Gy)...
Background An 11‐year‐old female spayed L abrador R etriever was presented with clinical signs of oestrus and vaginal bleeding. Historically, the dog had not cycled been at less than 6 months age. Results Extensive investigation culminated in diagnosis an ovarian granulosa cell tumour. The patient a history localised grade III mast tumour 5 years prior hepatic haemangiosarcoma 8 to diagnosis. Conclusions Both conditions were successfully treated combination surgery chemotherapy there no...
Development of a post-transplant kidney transplant tolerance induction protocol involving novel total lymphoid irradiation (TLI) conditioning method in rhesus macaque model is described. We examined the feasibility acheiving to MHC 1-haplotype matched transplants by establishing mixed chimeric state with infusion donor hematopoietic cells (HC) using TomoTherapy TLI. The was hypothesized permit elimination all immunosuppressive (IS) medications while preserving allograft function long-term...
Abstract As advanced delivery techniques such as intensity‐modulated radiation therapy (IMRT) become conventional in veterinary radiotherapy, highly modulated helps to decrease dose normal tissues. However, IMRT is only effective if patient setup and anatomy are accurately replicated for each treatment. Numerous have been implemented error, however tumor shrinkage, variations the patient's contour weight loss continue be hard control can result clinically relevant deviation radiotherapy...
Purpose: To test the sub‐second imaging achieved with ViewRay for accuracy and ability to track real‐time target motion during treatment delivery. Methods: A phantom incorporating MR compatibility was designed using QUASAR Respiratory Motion Phantom. silicon di‐electric gel poured into a cylindrical shape used as target, connected motor via rod. The driven sinusoidal trajectory of 20 mm amplitude. cycle length varied from 3 9 seconds per cycle. Images were acquired in sagittal plane every...