A5000694375- Veterinary Oncology Research
- Virus-based gene therapy research
- Head and Neck Surgical Oncology
- Infectious Diseases and Mycology
- Advanced Radiotherapy Techniques
- Oral and Maxillofacial Pathology
- Cancer Research and Treatments
- Sarcoma Diagnosis and Treatment
- Microbial infections and disease research
- Immunotherapy and Immune Responses
- Glioma Diagnosis and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Veterinary Orthopedics and Neurology
- Cancer Treatment and Pharmacology
- Cutaneous lymphoproliferative disorders research
- Cancer, Hypoxia, and Metabolism
- Effects of Radiation Exposure
- HER2/EGFR in Cancer Research
- Colorectal Cancer Treatments and Studies
- Salivary Gland Tumors Diagnosis and Treatment
- Skin Diseases and Diabetes
- Myasthenia Gravis and Thymoma
- Veterinary Medicine and Surgery
- Genetic and rare skin diseases.
- Management of metastatic bone disease
University of Wisconsin–Madison
2007-2024
John Wiley & Sons (United States)
2016-2023
University of Georgia
2011-2021
Hudson Institute
2016-2020
American College of Veterinary Radiology
2016
Clemson University
2016
Yonsei University
2012
Korea Institute of Science & Technology Information
2012
MSPCA-Angell
2006
Radboud University Nijmegen
1975
Abstract AtPUB18 and AtPUB19 are homologous U-box E3 ubiquitin ligases in Arabidopsis (Arabidopsis thaliana). is a negative regulator of abscisic acid (ABA)-mediated drought responses, whereas the role responses unknown. Here, loss-of-function overexpression tests identified as ABA-mediated stomatal closure water stress responses. The atpub18-2atpub19-3 double mutant line displayed more sensitivity to ABA enhanced tolerance than each single plant; therefore, agonistic. Stomatal was...
The medical records of 61 dogs with MCT at high risk for metastasis that were treated prednisone and VBL following excision +/- radiation therapy reviewed, median disease-free interval (DFI), overall survival time (OS) prognostic factors assessed. Adverse effects, mostly mild, noted in 26% patients, usually after the first dose. 6.5% experienced severe neutropenia. DFI was 1305 days, OS not reached, 65% alive 3 years. 100% "high-risk" grade II III 1374 days. Histologic grade, location...
The toxicity criteria of the veterinary radiation therapy oncology group (VRTOG) version 2 guidelines are a substantial update to reflect significant advances in over last three decades. Radiation techniques provide precise and spatially accurate delivery, which facilitates treating tumors more anatomic locations incorporating hypofractionated protocols. purpose this is aid teams capturing grading clinically relevant data that impacts decision-making process everyday practice assessment...
The purpose of this study was to evaluate response rates, 1st remission duration (FRD), and toxicity in dogs with previously untreated lymphoma receiving an identical CHOP-based combination chemotherapy protocol or without l-asparaginase (l-ASP). One hundred fifteen were scheduled receive that included l-ASP However, because manufacturer-imposed random rationing, 31 did not as scheduled. 2 treatment groups statistically similar respect signalment presence historical negative prognostic...
To evaluate factors associated with survival in dogs nasal carcinomas that did not receive treatment or received only palliative treatment.Retrospective case series.139 histologically confirmed carcinomas.Medical records, computed tomography images, and biopsy specimens of were reviewed. Only treated radiation, surgery, chemotherapy, immunotherapy survived > = 7 days from the date diagnosis included. The Kaplan-Meier method was used to estimate time. Factors potentially compared by use...
Intensity modulated radiation therapy (IMRT) allows optimization of dose delivery to complex tumor volumes with rapid drop-off surrounding normal tissues.A prospective study was performed evaluate the concept conformal avoidance using IMRT in canine sinonasal cancer.The potential improve clinical outcome respect acute and late ocular toxicity evaluated.Thirty-one dogs cancer were treated definitively helical tomotherapy and/or dynamic multileaf collimator (DMLC) delivery.Ocular evaluated...
Paclitaxel (Taxol ®) was administered to 25 dogs with histologically confirmed malignant tumors at a dosage of 165 mg/m 2 IV over 3–6 hours every 3 weeks. Dogs received premedication antihistimines and corticosteroids reduce hypersensitivity reactions. However, 64% the still experienced allergic Six (24%) had grade or 4 neutropenia, 6 required hospitalization (12%) died sepsis. Five (20%) partial response (osteosarcoma [2 dogs] mammary carcinoma histiocytosis [1 dog]) for median duration 53...
Background:Epitheliotropic lymphoma (ELSA) is an uncommon cutaneous canine malignancy of T lymphocytes. A consensus regarding the therapeutic standard care lacking, warranting evaluation chemotherapeutic agents traditionally employed against nodal in treatment ELSA. Hypothesis:The purpose this retrospective, multi‐institutional study was to evaluate efficacy 1‐(2‐chloroethyl)‐3‐cyclohexyl‐1‐nitrosourea (CCNU) Animals:Forty‐six dogs with adequate follow‐up and response information....
Canine oral melanoma (OM) is an aggressive cancer with a high rate of metastasis. Surgery and/or radiotherapy (RT) are effective local treatments, yet many dogs succumb to distant Immunotherapy represents attractive strategy for this potentially immunogenic tumor. The objective multi-institutional retrospective study was examine the clinical outcome OM treated ONCEPT vaccine. Most also underwent surgery RT (8 Gy × four weekly fractions). Dogs metastasis at diagnosis and those receiving...
Abstract The medical records of 15 dogs with anal sac adenocarcinoma (ASAC) treated concurrent curative‐intent radiotherapy and mitoxantrone (MX) after surgical removal the primary tumour were reviewed retrospectively. Radiation was prescribed at daily fractions 3.2 Gy for a total dose 48 Gy. MX given intravenously dosage 5 mg m −2 every 3 weeks five treatment sessions. Twelve received pelvic irradiation to include regional lymph nodes (LNs) three radiation only perineum. At time diagnosis,...
Paclitaxel (Taxol ®) was administered to 25 dogs with histologically confirmed malignant tumors at a dosage of 165 mg/m2 IV over 3–6 hours every 3 weeks. Dogs received premedication antihistimines and corticosteroids reduce hypersensitivity reactions. However, 64% the still experienced allergic Six (24%) had grade or 4 neutropenia, 6 required hospitalization (12%) died sepsis. Five (20%) partial response (osteosarcoma [2 dogs] mammary carcinoma histiocytosis [1 dog]) for median duration 53...
Epitheliotropic lymphoma (ELSA) is an uncommon cutaneous canine malignancy of T lymphocytes. A consensus regarding the therapeutic standard care lacking, warranting evaluation chemotherapeutic agents traditionally employed against nodal in treatment ELSA.The purpose this retrospective, multi-institutional study was to evaluate efficacy 1-(2-chloroethyl)-3-cyclohexyl-l-nitrosourea (CCNU) ELSA.Forty-six dogs with adequate follow-up and response information.All cases were diagnosed...
Canine malignant melanoma provides a clinically relevant, large animal parallel patient population to study the GD2-reactive hu14.18-IL-2 immunocytokine as it is similar human and expresses GD2. The objectives of this were evaluate safety, radiation fractionation, identify informative biomarkers an in-situ tumor vaccine involving local therapy plus intratumoral–immunocytokine in tumor-bearing dogs. Twelve dogs (six dogs/arm) with locally advanced or metastatic randomized receive single 8 Gy...
Dysregulation of platelet‐derived growth factor receptor (PDGFR) may play a role in feline injection‐site sarcoma (ISS) cell and viability. Masitinib, tyrosine kinase inhibitor approved for treatment canine mast tumours, is highly selective the PDGFR signalling pathway offer new therapeutic approach this disease. The vitro effects masitinib on growth, apoptosis two novel ISS lines were investigated. expression was confirmed by Western blot derived from primary tumour (JB) corresponding,...
Abstract Failure rate and site are not well defined in localized sinonasal lymphoma cats treated with radiotherapy. In this study, we describe (a) failure pattern, (b) outcome, (c) influence of previously reported prognostic variables on the outcome suspected lymphoma. multi‐institutional retrospective included 51 single‐modality Cats were irradiated using 10x4.2Gy (n = 32), 12x3Gy 11) or 5x6Gy 8). Regional lymph nodes prophylactically 24/51 (47.1%). Twenty‐five (49.0%) developed progressive...
Rationale Murine syngeneic tumor models have revealed efficacious systemic antitumor responses following primary in situ vaccination combined with targeted radionuclide therapy to secondary or metastatic tumors. Here we present studies on the safety and feasibility of this approach a relevant translational companion dog model (n = 17 dogs) advanced cancer. Methods The three component combination immuno-radiotherapy were employed either separately dogs stage In was achieved through...
This study describes the development of an human granulocyte–macrophage colony-stimulating factor DNA cationic-lipid complexed autologous tumour cell vaccine (hGM-CSF CLDC ATCV) and its implementation, following a chemotherapy treatment protocol, in randomized, placebo-controlled, double-blinded clinical trial pet dogs with naturally occurring lymphoma. We hypothesized that use this would result antitumour immune response leading to improved first remission duration overall survival B-cell...
Abstract Radiotherapy is the treatment of choice for non‐resectable canine thyroid carcinoma. High tumor response rates and median survival times 2 years or longer have been previously reported with conventionally fractionated hypofractionated protocols, even in dogs distant metastasis. The objective this retrospective, descriptive, case series study was to evaluate clinical outcomes carcinoma irradiated palliative intent using radiotherapy at our institution. Medical records 20 treated...
Contouring variability is a significant barrier to the accurate delivery and reporting of radiation therapy. The aim this descriptive study was determine variation in contouring targets organs at risk by participants within our institution. Further, we also aimed if all individuals contoured same normal tissues. Two canine nasal tumor datasets were selected two ACVR-certified oncologists oncology residents from Eight structures consistently including right left eye, lens, brain, gross volume...
Objectives The aim of this study was to evaluate the outcome cats with intracranial tumours presenting neurological signs treated radiation therapy. Methods This comprised a retrospective multicentre case series. Medical records total 22 space-occupying lesions, and/or epileptic seizures and external beam therapy, were reviewed. In cats, patient-, tumour- treatment-related variables investigated, including age, sex, tumour location, volume, dose, equivalent dose in 2 Gy fractions (EQD ),...
Abstract Dogs with sinonasal tumors cribriform plate lysis (modified Adams’ stage 4) treated non‐conformal definitive radiotherapy (RT) have short median survivals of 6‐7 months. Intensity‐modulated its greater conformality and tumor dose homogeneity may result in more favorable outcomes. epithelial or mesenchymal CT evidence that received 10 daily fractions 4.2 Gray using IMRT by helical tomotherapy were included this single‐institution retrospective case series study. distant metastasis,...
Abstract Since 2010, there has been little published data on the state of equipment and infrastructure in veterinary radiation oncology clinical practice. These are important not only to identify status use technology within community but also help extent medical physics support. The purpose our study is report findings from a survey oncologists USA, Canada, select centers outside North America 2022. A 40‐question covering topics such as type radiotherapy equipment, techniques offered,...