A5040499790- Chronic Myeloid Leukemia Treatments
- Chronic Lymphocytic Leukemia Research
- Genomics and Phylogenetic Studies
- Plant Molecular Biology Research
- Monoclonal and Polyclonal Antibodies Research
- Plant-Microbe Interactions and Immunity
- Plant Disease Resistance and Genetics
- Immunotherapy and Immune Responses
- Photosynthetic Processes and Mechanisms
- Acute Myeloid Leukemia Research
- Plant tissue culture and regeneration
- Hematopoietic Stem Cell Transplantation
- Cellular transport and secretion
- Economic Growth and Productivity
- Genomic variations and chromosomal abnormalities
- DNA Repair Mechanisms
- Endoplasmic Reticulum Stress and Disease
- Plant Reproductive Biology
- Plant Pathogens and Resistance
- Microbial Community Ecology and Physiology
- Glycosylation and Glycoproteins Research
- Legume Nitrogen Fixing Symbiosis
- Multiple Myeloma Research and Treatments
- Calcium signaling and nucleotide metabolism
- Prenatal Screening and Diagnostics
University of Wyoming
2024
Korea Polar Research Institute
2022-2024
Chinese PLA General Hospital
2009-2022
Ryukoku University
2021
Seoul National University
2014-2018
Plant immunity depends on massive expression of pathogenesis-related genes (PRs) whose transcription is de-repressed by pathogen-induced signals. Salicylic acid (SA) acts as a major signaling molecule in plant and systemic acquired resistance triggered bacterial or viral pathogens. SA signal results the activation master immune regulator, Nonexpressor 1 (NPR1), which thought to be recruited factors such TGAs numerous downstream PRs. Despite its key role SA-triggered immunity, biochemical...
Summary Posttranslational acetylation of histones is reversibly regulated by histone deacetylases ( HDAC s). Despite the evident significance s in Arabidopsis development, biological roles and underlying molecular mechanisms many are yet to be elucidated. By a reverse‐genetic approach, we isolated an hda9 mutant performed phenotypic analyses on it. In order address role HDA 9 flowering, genetic, molecular, biochemical approaches were employed. flowered early under noninductive short‐day SD )...
Abstract Mosses are vital components of ecosystems, exhibiting remarkable adaptability across diverse habitats from deserts to polar ice caps. Sanionia uncinata (Hedw.) Loeske, a dominant Antarctic moss survives extreme environmental condition through perennial lifecycles involving growth and dormancy alternation. This study explores genetic controls molecular mechanisms enabling S. cope with seasonality the environment. We analysed seasonal transcriptome dynamics collected monthly February...
Double minute chromosomes (DMs) are rare in hematologic malignancies. We presented the cytogenetic characteristics and clinical features of largest single-center cohort acute myeloid leukemia (AML) myelodysplastic syndrome (MDS) patients with DMs. A total 2576 AML 1642 MDS were investigated, 30 (AML = 19; 11) who had DMs followed up. more common primary (94.7%) (90.9%). Monosomal karyotypes (MK) also main characteristics, like complex (CK). myelodysplasia-related changes (AML-MRC)...
Phytophthora species, an oomycetes plant pathogen, secrete effectors into cell throughout their life cycle for manipulating host immunity to achieve successful colonization. However, the molecular mechanisms underlying effector-triggered necrotic death remain elusive. In this study, we identified RXLR effector (Pc12) from capsici which contributes virulence and induces necrosis by triggering a distinct endoplasmic reticulum (ER) stress response through its interaction with Rab13-2. The...
Abstract To achieve successful colonization, the pathogen secretes hundreds of effectors into host cells to manipulate host’s immune response. Despite numerous studies, molecular mechanisms underlying effector-induced necrotic cell death remain elusive. In this study, we identified a novel virulent RXLR effector named Pc12 from P. capsici. induces necrosis by triggering distinct ER stress response through its interaction with Rab13-2. Unlike conventional hypersensitive associated...
Single-stranded DNA-binding proteins (SSBs) are essential for DNA metabolism, including repair and replication, in all organisms. SSBs have potential applications molecular biology analytical methods. In this study, the first time, we purified, structurally characterized, analyzed psychrophilic SSB (LjSSB) from Lacinutrix jangbogonensis PAMC 27137 isolated Antarctic region. LjSSB has a relatively short amino acid sequence, consisting of 111 residues, with mass 12.6 kDa. protein was...
This study was aimed to investigate and analyze the HLA antigen compatibility between patients with hematologic diseases their parents so as provide basis for selecting suitable donors in haploidentical hematopoietic stem cell transplantation. The low resolution 174 families typed analyzed by using PCR-SSP. results showed that 52.30% of possessed father and/or mother matching over haploidentity, 10.92% were 8/10 matched mother. 11.49% semi-matched both rate 6/10 pairs (28.16%), 7/10 (16.1%)...
Objective To investigate the value of multiple short tandem repeat (STR)amplification by fluorescence labeling polymerase chain reaction (PCR) combined with fusion gene bcr-abl mRNA expression for quantitative determination chimerism and qualitative detection transcripts,and to evaluate status engraftment predict outcome allogeneic hematopoietic stem cell transplantation (allo-HSCT). Methods 5 relapse patients CML after alIo-HSCT were dynamically investigated. Quantitative analysis donor was...
To investigate an improved culturing method for karyotyping analysis, and increase the detection rate of cytogenetic abnormalities in patients with multiple myeloma (MM), so as to provide more powerful information clinical diagnosis, prognosis stratification, individualized treatment MM patients.Eighty newly-diagnosed were enrolled divided into two groups. In observation group, IL-6 (10 ng/ml) GM-CSF (30 supplemented culture medium, while no stimulating factor was added control group. The...