A5033215159- Advanced biosensing and bioanalysis techniques
- Biosensors and Analytical Detection
- Electrochemical Analysis and Applications
- Electrochemical sensors and biosensors
- Advanced Nanomaterials in Catalysis
- RNA Interference and Gene Delivery
- Molecular Sensors and Ion Detection
- Glycosylation and Glycoproteins Research
- 2D Materials and Applications
- Monoclonal and Polyclonal Antibodies Research
- Analytical Chemistry and Sensors
- Metal-Organic Frameworks: Synthesis and Applications
- Advanced Biosensing Techniques and Applications
- Luminescence and Fluorescent Materials
- Gold and Silver Nanoparticles Synthesis and Applications
- Radiopharmaceutical Chemistry and Applications
- Carbon and Quantum Dots Applications
- MXene and MAX Phase Materials
- Chalcogenide Semiconductor Thin Films
- Nanoplatforms for cancer theranostics
- Conducting polymers and applications
- Chemical Reactions and Isotopes
- HER2/EGFR in Cancer Research
- Toxin Mechanisms and Immunotoxins
- Peptidase Inhibition and Analysis
Hubei University
2019-2025
Ministry of Education of the People's Republic of China
2025
Southwest University
2014-2020
Chongqing University
2016-2020
University of California, Davis
2006-2012
Oregon Health & Science University
2012
California Northstate University
2012
University of California Davis Medical Center
2001
In this work, a novel mesoporous luminescence-functionalized metal-organic framework (Ru-PCN-777) with high stability and excellent electrochemiluminescence (ECL) performance was synthesized by immobilizing Ru(bpy)2(mcpbpy)2+ on the Zr6 cluster of PCN-777 via strong coordination bond between Zr4+ -COO-. Consequently, could not only cover surface but also graft into interior PCN-777, which greatly increased loading amount effectively prevented leaching resulting in stable ECL response....
Here, an ultrasensitive "off-on" electrochemiluminescence (ECL) biosensor was proposed for the determination of telomerase activity by using a self-enhanced ruthenium polyethylenimine (Ru-PEI) complex doped zeolitic imidazolate framework-8 (Ru-PEI@ZIF-8) with high ECL efficiency as indicator and enzyme-assisted DNA cycle amplification strategy. The Ru-PEI@ZIF-8 nanocomposites were synthesized Ru-PEI doping during growth (ZIF-8), which presented excellent stability. Furthermore, owing to...
Despite the widespread utilization of gold nanoparticles and graphene for in vivo applications, complex steps preparation functionalization these nanomaterials are commonly required. In addition, cytotoxicity such materials is currently still under debate. this work, by taking significant advantages DNA terms biocompatibility, nontoxicity, controllability as building blocks nanostructures, we describe construction a reconfigurable, multicolor-encoded nanostructure multiplexed monitoring...
Since aggregation-induced electrochemiluminescence (AIECL) combined the merits of emission (AIE) and (ECL), it has become a research hotspot recently. Herein, novel kinds functional metal-organic frameworks (MOFs) with strong AIECL were reported through doping tetraphenylethylene (TPE) into UiO-66. Due to porosity highly ordered topological structure that caused confinement effect MOFs, molecular motion TPE was effectively limited within UiO-66, resulting in AIE. Meanwhile, large specific...
A universal ratiometric photoelectrochemical (PEC) bioassay, which could be readily expanded for ultrasensitive determination of various targets in complex biological matrixes, was established by coupling a target-nucleotide transduction-amplification with DNA nanomachine mediated electron-transfer tunneling distance regulation strategies. With the help strategy, one input target signal transducted to corresponding multiple output signals nucleotide specific recognition technology,...
Here, a sensitive electrochemiluminescence (ECL) biosensor using N doped carbon dots (N-CDs) as luminophores, and Pd–Au hexoctahedrons (Pd@Au HOHs) enhancers, was developed for the detection of intracellular Pb<sup>2+</sup>.
Novel luminescence-functionalized metal-organic frameworks (MOFs) with superior electrogenerated chemiluminescence (ECL) properties were synthesized based on zinc ions as the central and tris(4,4'-dicarboxylicacid-2,2'-bipyridyl)ruthenium(II) dichloride ([Ru(dcbpy)3](2+)) ligands. For potential applications, MOFs used to fabricate a "signal-on" ECL immunosensor for detection of N-terminal pro-B-type natriuretic peptide (NT-proBNP). As expected, enhanced signals obtained through simple...
The self-enhanced electrochemiluminescence (ECL) with high sensitivity could be an effective method for anticancer drug screening cell apoptosis monitoring. Here we reported ultrasensitive ECL cytosensor monitoring by using electrochemiluminescent ruthenium–silica composite nanoparticles (Ru–N–SiNPs) labeled annexin V as signal probes. Ru–N–SiNPs were first synthesized through simple hydrolysis of a novel precursor containing luminescent and intracoreactant groups in one molecule, which...
In this work, a self-enhanced ultrasensitive photoelectrochemical (PEC) biosensor was established based on functionalized nanocapsule packaging both donor–acceptor-type photoactive material and its sensitizer. The with PEC responses achieved first by the (poly{4,8-bis[5-(2-ethylhexyl)thiophen-2-yl]benzo[1,2-b:4,5-b′]dithiophene-2,6-diyl-alt-3-fluoro-2-[(2-ethylhexyl)carbonyl]thieno[3,4-b]thiophene-4,6-diyl}, PTB7-Th) sensitizer (nano-C60, fullerene) in poly(ethylene glycol) (PEG) to form...
MicroRNAs (miRNAs) as a well-known kind of cancer marker are closely associated with the formation and metastasis tumors. Here, novel tetraphenylethylene (TPE)-doped covalent organic frameworks (TPE-COFs) strong aggregation-induced electrochemiluminescence (AIECL) response was synthesized introduced to construct an ultrasensitive biosensor for detection miRNA-21. The emission (AIE) obtained because molecular motion TPE restricted by COFs which had porosity highly ordered topological...
Heavy metal ions are persistent environmental contaminants and pose a great threat to human health, which has prompted demand for new methods selectively identify detect these ions. Herein, novel fluorescent assay based on rolling-circle-amplification (RCA)-assisted multisite-strand-displacement-reaction (SDR) signal-amplification strategy was proposed the ultrasensitive detection of heavy with lead (Pb2+) as model. The not only achieved target recycling but also introduced RCA induced by...
Electrochemiluminescent (ECL) assay with high sensitivity has been considered as one of the potential strategies to simultaneously detect multiple biomarker proteins. However, it was essential, but full challenges, overcome limitation caused by cross reactions among different ECL indicators. Herein, multiparameter analysis ECL-potential signals demonstrated multivariate linear algebraic equations first employed in simultaneous realize detection proteins on a single interface. Additionally,...