A5061140962- Infant Nutrition and Health
- Probiotics and Fermented Foods
- Gut microbiota and health
- Digestive system and related health
- Oral microbiology and periodontitis research
- Dental Health and Care Utilization
- Sarcoidosis and Beryllium Toxicity Research
- Endodontics and Root Canal Treatments
- Pediatric Hepatobiliary Diseases and Treatments
- Neonatal Respiratory Health Research
- Hormonal Regulation and Hypertension
- Vitamin K Research Studies
- Genetic factors in colorectal cancer
- Eosinophilic Disorders and Syndromes
- Biochemical Analysis and Sensing Techniques
- Nutritional Studies and Diet
- Vitamin C and Antioxidants Research
- Protein Structure and Dynamics
- ATP Synthase and ATPases Research
- Eating Disorders and Behaviors
- Inflammatory Myopathies and Dermatomyositis
- Salivary Gland Disorders and Functions
- Bacterial biofilms and quorum sensing
- Colorectal Cancer Screening and Detection
- Breastfeeding Practices and Influences
DuPont (Finland)
2014-2020
University of Turku
2002-2020
DuPont (United States)
2015-2019
University of Helsinki
2013
Prebiotic human milk oligosaccharides (HMOs) are found in milk, which not digested by infants but metabolized beneficial gut bacteria. We determined the ability of 57 bacterial strains within Family Lactobacillaceae and genera Bifidobacterium Bacteroides potentially pathogenic bacteria to ferment HMOs 2′-fucosyllactose, 3-fucosyllactose, difucosyllactose. In addition, prebiotic galacto-oligosaccharides (GOS), lactose, fucose, glucose were evaluated as carbon sources for these strains....
Abstract Human milk oligosaccharides (HMOs) shape gut microbiota during infancy by acting as fermentable energy source. Using a semi-continuous colon simulator, effect of an HMO, 2′-fucosyllactose (2′-FL), on composition the infant and microbial metabolites was evaluated in comparison to galacto-oligosaccharide (GOS) lactose control without additional carbon Data analysed according faecal sample donor feeding type: breast-fed (BF) or formula-fed (FF), rate 2′-FL fermentation: fast slow....
Human milk oligosaccharides (HMOs) function as prebiotics for beneficial bacteria in the developing gut, often dominated by Bifidobacterium spp. To understand relationship between bifidobacteria utilizing HMOs and how metabolites that are produced could affect host, we analyzed metabolism of HMO 2'-fucosyllactose (2'-FL) longum subsp. infantis Bi-26. RNA-seq metabolite analysis (NMR/GCMS) was performed on samples at early (A600 = 0.25), mid-log (0.5-0.7) late-log phases (1.0-2.0) growth....
Dietary fibers are associated with enhanced satiety. However, the mechanism of different dietary contributing to satiety-related gastrointestinal (GI) peptide release, especially in an obese population, is still poorly understood. Polydextrose (PDX), a water-soluble glucose polymer, has demonstrated its ability reduce energy intake at subsequent meal, but action requires further research. Also, there limited evidence on capacity regulate subjective feelings appetite. This study examines...
Human milk oligosaccharides (HMOs) shape the developing infant gut microbiota. In this study, a semi-continuous colon simulator was used to evaluate effect of 2 HMOs-2'-fucosyllactose (2'-FL) and 3-fucosyllactose (3-FL)-on composition faecal microbiota microbial metabolites. The simulations were performed with without probiotic Bifidobacterium longum subspecies infantis Bi-26 (Bi-26) compared control that lacked an additional carbon source. treatments HMOs decreased α-diversity increased...
The interplay between probiotic metabolites, host health, and inhibition of pathogens has increasingly attracted interest but remains unresolved due to the complex molecular interactions among these factors. We investigated action cell-free supernatants (CFSs) from two bacteria, Bifidobacterium animalis spp. lactis (B. lactis) HN019 Lacticaseibacillus rhamnosus (L. rhamnosus) HN001 their effect against bacterial pathogen Shigella flexneri 2457T (S. flexneri). CFSs B. exhibited a higher...
Abstract Human milk oligosaccharides, such as 2′-fucosyllactose (2′-FL), and galacto-oligosaccharides (GOS), a prebiotic carbohydrate mixture, are being increasingly added to infant formulas, necessitating the understanding of their impact on oral microbiota. Here, for first time, effects 2′-FL GOS planktonic growth adhesion characteristics caries-associated pathogen Streptococcus mutans were assessed, results compared against xylitol, lactose glucose. There differences in S. between GOS....
Human milk oligosaccharides (HMOs), the third largest solid fraction in human milk, can modulate inflammation through Toll-like receptor signaling, but little is known about their immunomodulatory potential oral cavity. In this study, we determined whether HMOs 2′-fucosyllactose (2′-FL) and 3-fucosyllactose (3-FL) regulate human-beta defensin (hBD)-2 -3, cathelicidin (hCAP18/LL-37), cytokine responses gingival cells using a three-dimensional mucosal culture model. The model was incubated...
Background— The HLA-DRB1*01 allele of the human leukocyte antigen has been associated with acute coronary syndrome. Genome-wide association studies have revealed associations and non–human genes 3 major histocompatibility complex gene classes but not at allelic level. Methods Results— We conducted a large-scale genetic analysis on case–control cohort comprising 5376 syndrome cases 4852 unrelated controls from 4 populations 2 European countries. analyzed risk candidate by genomic real-time...
Human breast milk contains a high quantity of oligosaccharides (HMOs) which are not digested by infants but selectively utilized beneficial gut microbes such as Bifidobacterium species. The microbiome in breast-fed is dominated species, whereas formula-fed have higher representation Bacteroides and Enterobacteria aim this study was to evaluate the ability various potentially pathogenic bacteria commercially available probiotic strains grow using HMOs 2'-fucosyllactose (2'-FL)...
Given that vascular calcification is inversely correlated with the clinical intake of menaquinone, a rat model warfarin-induced may be useful for testing menaquinone and vitamin K-1 potential effects on function. The aim present study was to investigate menaquinone-7 treatments blood pressure function in during five-week intervention normotensive Wistar-Kyoto rats. Blood measured weekly, at end vitro reactivity measurements were done. Alizarin Red S von Kossa stainings used record possible...