A5057932145- Pesticide Exposure and Toxicity
- Chemotherapy-induced organ toxicity mitigation
- Insect and Pesticide Research
- Pharmacological Effects of Medicinal Plants
- Biochemical effects in animals
- Drug-Induced Hepatotoxicity and Protection
- Insect Pest Control Strategies
- Heavy Metal Exposure and Toxicity
- Nigella sativa pharmacological applications
- Moringa oleifera research and applications
- Forensic Entomology and Diptera Studies
- Potato Plant Research
- Acute Lymphoblastic Leukemia research
- Pesticide and Herbicide Environmental Studies
- Protein Hydrolysis and Bioactive Peptides
- Heme Oxygenase-1 and Carbon Monoxide
- Cell death mechanisms and regulation
- Nanoparticles: synthesis and applications
- Paraoxonase enzyme and polymorphisms
- Echinoderm biology and ecology
- Environmental Toxicology and Ecotoxicology
- Seaweed-derived Bioactive Compounds
- Parasitic infections in humans and animals
- Cancer Research and Treatment
- Sesame and Sesamin Research
Benha University
2017-2024
Cairo University
2023
October 6 University
2023
Cisplatin (CP) is one of the most frequently used chemotherapy agents. The objective this design was to determine ameliorative effect lycopene (LP) and/or N-acetylcysteine (NAC) in rats with hepatic and renal toxicity induced by CP. Rats were divided randomly into 7 groups (7 rats/group): control vehicle group (saline only), LP (10 mg/kg, orally), NAC (150 CP (7.5 IP on day 27), LP-CP group, NAC-CP LP-NAC-CP group. activities alanine aminotransferase (ALT), aspartate (AST), alkaline...
Deltamethrin (DLM) is a synthetic pyrethroid with anti-acaricide and insecticidal properties. It commonly used in agriculture veterinary medicine. Humans animals are exposed to DLM through the ingestion of polluted food water, resulting severe health issues. N-acetylcysteine (NAC) prodrug L-cysteine, precursor glutathione. can restore oxidant-antioxidant balance. Therefore, this research aimed examine whether NAC may protect broiler chickens against oxidative stress, at level biochemical...
Salsola imbricata is a herbal plant native to Saudi Arabia, known for its antioxidative and anti-inflammatory properties. This study explored the protective effects of an ethanolic leaf extract against oxidative stress hepatic injury caused by acrylamide. Rats received intragastric administrations 20 mg/kg body weight acrylamide induce injury, or 300 orally 7 days before administration. The treatments were continued 3 weeks. Blood liver samples collected from all groups, following...
The current study was aimed to evaluate the protective effect of Holothurian atra (HA) extract; naturally occurring marine resource, against methotrexate (MTX) induced testicular dysfunction. Mature rats received either MTX (20 mg/kg, intraperitoneally) or saline on 7th day experiment al design. Seven days prior and after MTX-injection, HA at dose 300 mg/kg intragastrically (HA + group; group alone). Serum extracted tissues were examined for changes in serum biochemistry (liver & kidney...
Abstract Because of their beneficial properties, natural products, especially medicinal plants, are becoming increasingly popular worldwide and play a significant role in research. This study was aimed to evaluate the nephroprotective effect sinapic acid against mercuric chloride-induced renal toxicity mice. The mice were allocated four groups named normal group (G1), model (G2; received HgCl2, 1 mg/kg bw), treatments (G3 G4: 50 100 bw together with HgCl2). Mice HgCl2 remarkably showed...
Glycyrrhiza glabra root (licorice) is a widely used herb for its beneficial effects on health. This study explored the protective of licorice extract against oxidative stress and testicular dysfunction caused by methotrexate (MTX). Mice were allocated into (i) negative control group that received saline; (ii) group, orally administered with 200 mg/kg body weight (bw) 12 days; (iii) positive MTX-intoxicated injected single intraperitoneal dose MTX (20 bw) day 7; (iv) days then 7 as in groups...
GA3 is widely used as a growth stimulant in agricultural regions. The long-term use of can cause organs damage. Chrysin flavonoid found nature that commonly to treat organ toxicity. In this study, we examined the effect chrysin on testes function GA3-affected rats. A total 24 male Wistar rats were divided into 4 groups. Saline was given control group. group orally 50 mg/kg/BW saline. received daily oral gavage (55 mg/kg/BW). protective (chrysin + GA3) and those described There an increase...
This research investigated the antioxidant activities and quality characteristics of functional yogurt supplemented with naturally derived protein, specifically lysozyme (LZ), as well its thermally modified variants PLZ treated at 63°C for 30 minutes (hold type pasteurization method) BLZ 100°C 10 (using boiling temperature). Among these variants, best capacity was reported PLZ, followed by LZ. Subsequently, different samples (YCtrl, YLZ, YPLZ, YBLZ) were prepared. Through weekly assessments,...
This study was done on 4 groups of mice to evaluate the cytogenotoxicity cobalt oxide nanoparticles by comet assay from liver tissue and bone marrow detect DNA damage histopathological changes in hepatic tissues.Significant elevation %DNA, tail length, moment while showed 5% decline 10% 20% nanoparticles.The tissues nanoparticle group had areas hepatocellular necrosis, focal aggregations mononuclear inflammatory cells, portal congestion, whereas marked cell infiltration, vascular small...
High altitude (HA) poses various dangers to living organisms, the most serious of which are oxidative stress and its accompanying metabolic problems, as well hypoxia associated abnormalities. Acrylamide is a poisonous chemical produced under result intracellular reactive oxygen species formation toxicity. Heating carbohydrates-rich meals give acrylamide that widely used in industry. The precise mechanism toxicity unknown. current study aimed examine impacts Taify pomegranate juice (TPJ) from...
Background: Heavy metals that normally cause problems are mercury (HgCl2) and lead acetate (LA). Chelating
 inhibitor agents the target to treat overcome metal toxicity. The current study has been carried out to
 evaluate protective effects of N-acetyl cysteine (NAC) meso 2,3 dimercaptosuccinic acid (DMSA) against
 HgCl2 LA toxicity.
 Materials Methods: Ninety male Wistar rats were divided into nine equal groups. groups administered
 NAC and/or DMSA in presence or...
The current work was done on four groups of rats (10 for each) to detect the hepato-protective characters curcumin toxicity induced by lithium carbonate. oral administration Li2 Co3 one-month lead noticeable decrease in SOD, CAT and GSH while increase GPx some histological changes portal tissues including hydropic degeneration thickening wall veins with numerous vacuolar degenerations were detected most liver cells. Haemorrghic, edematous blood vessels noticed tissues. Focal areas...
This study was done on 81 rats to evaluate the post mortem interval PMI depending expression of Gapdh mRNA and protein response immunostaining.
This study was done on 5 groups of poultry chicks from one day up to 45 days age. We usedblue green algae as source feed additives added the water and ration in addition peppermintto evaluate protective effect peppermint against toxicity induced by blue algae.The administration chicken food caused hepato- cardio toxicityindicated significant increase liver (ALT AST) heart enzymes (CK LDH) decreasein MDA CAT. The showed histopathological alterations form congestion inthe central vein,...
Abstract Deltamethrin (DM) is a synthetic pyrethroid insecticide commonly used in veterinary and agriculture. However, both animal human exposure associated with hepatorenal toxicity. Our experimental goal was to assess the protective effects of Spirulina plantesis (SP ) against DM-induced hepato-renal injury, growth performance, meat chemical composition its residues meat, liver skin broiler chickens. Sixty one-day-old Cobb chicks were assigned 4 groups, each divided into 3 replicates five...