A5010646150- Hepatocellular Carcinoma Treatment and Prognosis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Liver Disease and Transplantation
- Liver Disease Diagnosis and Treatment
- Vascular Procedures and Complications
- Aortic Disease and Treatment Approaches
- Gallbladder and Bile Duct Disorders
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac Valve Diseases and Treatments
- Aortic aneurysm repair treatments
- Renal cell carcinoma treatment
- Peptidase Inhibition and Analysis
- Chromatin Remodeling and Cancer
- Cancer, Lipids, and Metabolism
- Peripheral Artery Disease Management
- Central Venous Catheters and Hemodialysis
- Organ Transplantation Techniques and Outcomes
- Maternal and fetal healthcare
- Nutrition and Health in Aging
- Folate and B Vitamins Research
- Abdominal vascular conditions and treatments
- Chemotherapy-related skin toxicity
- Viral-associated cancers and disorders
- Mycobacterium research and diagnosis
- Organ Donation and Transplantation
Helios Dr. Horst Schmidt Kliniken Wiesbaden
2022
University Medical Center of the Johannes Gutenberg University Mainz
2017-2021
Johannes Gutenberg University Mainz
2011-2021
Klinik und Poliklinik für Psychosomatische Medizin und Psychotherapie
2011-2019
University of Applied Sciences Mainz
2015
To evaluate the incidence, management, and outcome of visceral artery aneurysms (VAA) over one decade.233 patients with 253 VAA were analyzed according to location, diameter, aneurysm type, aetiology, rupture, outcome.VAA localized at splenic artery, coeliac trunk, renal hepatic superior mesenteric other locations. The aetiology was degenerative, iatrogenic after medical procedures, connective tissue disease, others. rate rupture much higher in pseudoaneurysms than true (76.3% vs.3.1%)....
Abstract Background & Aims Portal vein tumour thrombosis (PVTT) has a significant impact on the prognosis of patients with hepatocellular carcinoma (HCC). The degree PVTT varies from sub‐/segmental invasion to complete occlusion main trunk. Aim this study was evaluate whether correlates prognosis. Methods A total 1317 HCC treated at our tertiary referral centre between January 2005 and December 2016 were included. diagnosed by contrast‐enhanced computed tomography or magnetic resonance...
Abstract Background and aims Deciding when to repeat stop transarterial chemoembolization (TACE) in patients with hepatocellular carcinoma (HCC) can be difficult even for experienced investigators. Our aim was develop a survival prediction model such undergoing TACE using novel machine learning algorithms compare it conventional scores, ART, ABCR SNACOR. Methods For this retrospective analysis, 282 who underwent HCC at our tertiary referral centre between January 2005 December 2017 were...
Sarcopenia has emerged as a prognostic parameter in numerous cancer entities. Current research favours its role determining factor for overall survival (OS) patients with intrahepatic cholangiocarcinoma (ICC); however, it is unclear whether sarcopenia truly independent predictor if combined established factors.Between 1997-2018, 417 histopathologically confirmed ICC were referred to our centre, of whom 293 included this study. Cross-sectional imaging, laboratory examinations and...
Background Portal vein tumor thrombosis (PVTT) is a frequent complication of hepatocellular carcinoma (HCC), which leads to classification as advanced stage disease (regardless the degree PVTT) according Barcelona Clinic Liver Cancer Classification. For such patients, systemic therapy standard care. However, in clinical reality, many patients with PVTT undergo different treatments, resection, transarterial chemoembolization (TACE), selective internal radiation (SIRT), or best supportive care...
Abstract Background There is strong evidence that portal vein tumor thrombosis (PVTT) associated with poor survival in patients hepatocellular carcinoma (HCC). However, data regarding the clinical significance of hepatic (HVTT) rare, particularly Western patients. Objective To determine HVTT prevalence a patient population and its impact on survival. Methods We included 1310 HCC treated our tertiary referral center between January 2005 December 2016. PVTT were diagnosed contrast‐enhanced...
Transarterial chemoembolisation is the standard of care for intermediate stage (BCLC B) hepatocellular carcinoma, but it challenging to decide when repeat or stop treatment. Here we performed first external validation SNACOR (tumour Size and Number, baseline Alpha-fetoprotein, Child-Pugh Objective radiological Response) risk prediction model. A total 1030 patients with carcinoma underwent transarterial at our tertiary referral centre from January 2000 December 2016. We determined following...
In hepatocellular carcinoma (HCC), the third leading cause of cancer-related mortality worldwide, Child-Turcotte-Pugh score (CTP) is one most established tools to assess hepatic reserve and determine survival. Serum levels insulin-like growth factor-1 (IGF-1) are decreased in patients with chronic liver disease or HCC. A modified combining circulating IGF-1 CTP (IGF-CTP) was recently proposed.IGF-CTP scoring evaluated 216 diagnosed HCC between 2007 2017 predictive value serum for patient...
External validation of prognostic risk models is essential before they are implemented in clinical practice. This study evaluated the recently developed MEGNA score for survival prediction after resection intrahepatic cholangiocarcinoma (ICC), with a focus on direct comparison its value to that current International Union Against Cancer (UICC)/American Joint Committee (AJCC) staging system.Between 1997 and 2018, 417 consecutive patients ICC were referred our tertiary care centre...
Portal vein infiltration (PVI) is a typical complication of HCC. Once diagnosed, it leads to classification as BCLC C with an enormous impact on patient management, systemic therapies are henceforth recommended. Our aim was investigate whether radiomics analysis using imaging at initial diagnosis can predict the occurrence PVI in course disease. Between 2008 and 2018, we retrospectively identified 44 patients HCC in-house, multiphase CT scan who presented without CT-detectable but developed...
Zusammenfassung Mutationen des hepatocyte nuclear factor 1 α-(HNF1α) Gens lösen einen MODY3-Diabetes aus und sind mit einer hepatozellulären Adenomatose assoziiert. Eine maligne Transformation von HNF1α-mutierten Adenomen ist selten. Wir beschreiben hier den Fall eines 28-jährigen Mannes heterozygoter HNF1α-Keimbahnmutation multiplen, HNF1α-inaktivierten Adenomen, der ein inflammatorisches Adenom β-Catenin-Mutation maligner in gut differenziertes hepatozelluläres Karzinom (HCC) entwickelte.
Bei einer 34J. IIG0P traten rezidivierende überperiodenstarke vaginale Blutungen über 10 Tage auf. der Patientin war sieben Wochen zuvor eine Abortcurettage nach Interruptio bei fetaler Trisomie 21erfolgt.
Objectives: To analyze the value of ECG-gated MD-CT for diagnosis subtle or discrete dissection ascending aorta, defined as an intimal tear without intimomedial flap evident intramural haematoma and to correlate these results with intraoperative findings histopathology.
Zusammenfassung Akute Erkrankungen der thorakalen Aorta sind zwar eher selten, aber lebensbedrohlich. Sie erfordern daher eine rasche Diagnostik und Therapie. Diagnostisch spielt dabei die CT-Angiografie zentrale Rolle, therapeutisch stehen offene Ersatz bei ascendens endovaskulären Therapieverfahren descendens an erster Stelle.
Portal vein tumor thrombosis (PVTT) significantly impairs the prognosis of patients with hepatocellular carcinoma (HCC) and classifies them as advanced stage (BCLC-C). However, relevance liver infiltration (LVI) remains unclear. Aim this study is to compare different forms macrovascular might influence choice treatment.