A5034700440- Renal and related cancers
- Microtubule and mitosis dynamics
- COVID-19 and healthcare impacts
- Genetic and Kidney Cyst Diseases
- Neuroendocrine Tumor Research Advances
- Neuroblastoma Research and Treatments
- Epigenetics and DNA Methylation
- COVID-19 Clinical Research Studies
- Endoplasmic Reticulum Stress and Disease
- Healthcare cost, quality, practices
- Ethics and Legal Issues in Pediatric Healthcare
- Glioma Diagnosis and Treatment
- Tumors and Oncological Cases
- Lung Cancer Research Studies
- Renal cell carcinoma treatment
- Schizophrenia research and treatment
- Venous Thromboembolism Diagnosis and Management
- Ferroptosis and cancer prognosis
- Counseling, Therapy, and Family Dynamics
- Child Abuse and Trauma
- Autoimmune Bullous Skin Diseases
- Child Welfare and Adoption
- Economic and Financial Impacts of Cancer
- Drug-Induced Adverse Reactions
- Attachment and Relationship Dynamics
Fox Chase Cancer Center
2018-2024
AdventHealth Tampa
2024
Montclair State University
2020-2021
Erie County Medical Center
2021
Nationwide Children's Hospital
2016-2019
Baylor College of Medicine
2015
The Ohio State University
2015
University of Minnesota
2001
Twin Cities Orthopedics
2001
Abstract Purpose: To investigate the role and significance of TP53 mutation in diffusely anaplastic Wilms tumors (DAWTs). Experimental Design: All DAWTs registered on National Tumor Study-5 (n = 118) with available samples were analyzed for mutations copy loss. Integrative genomic analysis was performed 39 selected DAWTs. Results: Following a single random sample, 57 (48%) demonstrated mutations, 13 (11%) loss without mutation, 48 (41%) lacked both [defined as TP53-wild-type (wt)]. Patients...
Abstract Background Metastatic high-grade neuroendocrine neoplasms (G3NENs) have limited treatment options after progression on platinum-based therapy. We addressed the role of Pembrolizumab in patients with previously treated metastatic G3NENs. Methods Two open-label, phase 2 studies enrolled G3NEN (Ki-67 > 20%) to receive at 200 mg I.V. every 3 weeks. Radiographic evaluation was conducted 9 weeks overall response rate as primary endpoint. Results Between November 2016 and May 2018, 29...
Abstract Wilms tumour is an embryonal of childhood that closely resembles the developing kidney. Genomic changes responsible for development majority tumours remain largely unknown. Here we identify recurrent mutations within involve highly conserved YEATS domain MLLT1 (ENL), a gene known to be involved in transcriptional elongation during early development. The mutant protein shows altered binding acetylated histone tails. Moreover, -mutant show increase MYC expression and HOX...
// Saskia L. Gooskens 1,2 , Samantha Gadd 3 Jaime M. Guidry Auvil 4 Daniela S. Gerhard Javed Khan 5 Rajesh Patidar Daoud Meerzaman 6 Qing-Rong Chen Chih Hao Hsu Chunhua Yan Cu Nguyen Ying Hu Charles G. Mullighan 7 Jing Ma Lawrence J. Jennings Ronald R. de Krijger 8,9 Marry van den Heuvel-Eibrink 2 Malcolm A. Smith 10 Nicole Ross 11 Julie Gastier-Foster and Elizabeth Perlman 1 Department of Pediatric Hematology Oncology, Erasmus MC - Sophia Children's Hospital, Rotterdam, The Netherlands...
Ciliary microtubules are subject to post-translational modifications that act as a "Tubulin Code" regulate motor traffic, binding proteins and stability. In humans, loss of CCP1, cytosolic carboxypeptidase tubulin deglutamylating enzyme, causes infantile-onset neurodegeneration. C. elegans, mutations in ccpp-1, the homolog result progressive degeneration neuronal cilia function. To identify genes microtubule glutamylation ciliary integrity, we performed forward genetic screen for suppressors...
This study examines potential links between early risk and problematic developmental outcomes in a sample of adopted children during middle childhood (mean age = 7. 8 years). No direct relation was found prenatal, perinatal, or preplacement factors socioemotional adjustment. When 12 high-risk their families were studied more intensively, collaboration relationships within the adoptive kinship network did account for variations these children. Collaboration refers to proactive cooperation...
4104 Background: There is currently no standard therapy for metastatic HG-NENs after progression on platinum based and available chemotherapy of limited benefit. Given the promising activity checkpoint inhibitors in small cell lung cancer, we initiated a phase II trial P (PD-1 inhibitor) pts with previously treated HG-NENs. Methods: A prospective, open-label, 2 trial, which metastatic, histologically confirmed (Ki67 > 20%), excluding lung/thymus origin, were eligible prior therapy. Other...
Gangliogliomas (WHO grade I) are rare tumors affecting the central nervous system and most frequently observed in children. Next-generation sequencing of is being utilized at an increasing rate both research clinical settings to characterize genetic factors that drive tumorigenesis. Here, we report a BRAF somatic mutation (NM_004333.4:c.1794_1796dupTAC; p.Thr599dup) tumor genome from pediatric patient her late teens, who was initially diagnosed with low-grade ganglioglioma age 13. This...
Construct validity of the Global Assessment Relational Functioning (GARF) was assessed using a health services research approach, mode study that captures naturalistic practice service providers. A sample 395 couple/family cases with GARF scores assigned pre- and post-therapy by 222 community-based marriage family therapists yielded these results: 1) pretreatment were negatively correlated severity client problems; 2) change positively reported changes in functioning; 3) therapist-reported...
Abstract Microtubules (MTs) are cytoskeletal elements that provide structural support and act as roadways for intracellular transport in cells. MTs also needed neurons to extend maintain long axons dendrites establish connectivity transmit information through the nervous system. Therefore, neurons, ability independently regulate stability MT-based different cellular compartments is essential. Posttranslational modification of one mechanism by which cytoskeleton. The carboxypeptidase CCP1...
Carcinoid heart disease (CHD) is a rare but potentially life-threatening sequela of advanced neuroendocrine neoplasm with carcinoid syndrome. These tumors can secrete vasoactive substances which serotonin the most prevalent. typically involves right-sided valves and eventually leads to right failure. Monitoring N-terminal pro-B-type natriuretic peptide 5-hydroxyindoleacetic acid at diagnosis during treatment, as well cardiac echocardiogram, helps screen for CHD. Many patients are not...
Abstract Ciliary microtubules are subject to post-translational modifications that act as a “Tubulin Code” regulate motor traffic, binding proteins and stability. In humans, loss of CCP1, c ytosolic arboxy p eptidase tubulin deglutamylating enzyme, causes infantile-onset neurodegeneration. C. elegans, mutations in ccpp-1 , the homolog result progressive degeneration neuronal cilia function. To identify genes microtubule glutamylation ciliary integrity, we performed forward genetic screen for...
66 Background: Poor dietary patterns are clearly implicated in the pathogenesis of CRC and increasingly associated with worsened outcomes, including a higher risk cancer recurrence mortality. We evaluated use novel computerized FFQ technology to assess patients who were undergoing surveillance. Methods: recruited stage I-III had completed curative intent therapy at least 1 year but no more than 5 years prior enrollment. Dietary assessment was conducted using (VioScreen) either clinic or...
Introduction: Coronavirus disease 2019 is a global health threat often accompanied with coagulopathy. Despite use of thromboprophylaxis in this population, thrombotic event rates are high. Materials and methods: This was multicenter, retrospective cohort study comparing the safety effectiveness strategies at 2 institutions hospitalized patients coronavirus 2019. Regimen A utilized higher-than-standard dosage B received full-dose anticoagulation for any D-dimer 3 mcg/mL or greater...
Abstract Introduction: The National Cancer Institute's Therapeutically Applicable Research to Generate Effective Treatments (TARGET) initiative seeks characterize the genomes of high-risk pediatric tumors identify therapeutic targets. High-Risk Renal Tumor TARGET includes analysis pre-therapy favorable histology Wilms Tumors (FHWT) that relapsed and with diffuse anaplasia (unfavorable histology; DAWT). These two tumor subsets have survival rates approximately 50% 60%, respectively....
Abstract Cancer treatment strategies targeting the tumor microenvironment and corresponding immune cell infiltrate (i.e., immunotherapy) have recently proven effective against many solid tumors. In pediatric brain cancers, there is little known about microenvironment. We aim to characterize populations of tumors, which will better inform us infiltration in different cancer subtypes may indicate potential for patient response immunotherapy. The Institute Genomic Medicine at Nationwide...
Abstract Microtubules (MTs) are cytoskeletal elements that provide structural support, establish morphology, and act as roadways for intracellular transport in cells. Neurons extend must maintain long axons dendrites to transmit information through the nervous system. Therefore, neurons, ability independently regulate stability MT-based different cellular compartments is essential. Post-translational modification of MTs one mechanism by which neurons can cytoskeleton. The carboxypeptidase...
Purpose The coronavirus disease 2019 (COVID-19) pandemic is posing unprecedented challenges for patient care, especially cancer patients. This study looks at asymptomatic (AS) COVID-19 positivity in patients and its effects on their care. Methods We conducted a retrospective chart review of AS testing positive upon screening Fox Chase Cancer Center between January 2020 September 2020. Relationships tests demographics, clinical characteristics, treatment delays were investigated using...