A5085018653- Acute Lymphoblastic Leukemia research
- Acute Myeloid Leukemia Research
- Chronic Myeloid Leukemia Treatments
- Chronic Lymphocytic Leukemia Research
- Advanced biosensing and bioanalysis techniques
- Lymphoma Diagnosis and Treatment
- Immune Cell Function and Interaction
- Childhood Cancer Survivors' Quality of Life
- Immunotherapy and Immune Responses
- interferon and immune responses
- RNA Interference and Gene Delivery
- Immune cells in cancer
- Hematopoietic Stem Cell Transplantation
- Molecular Biology Techniques and Applications
- Algal biology and biofuel production
- Inflammasome and immune disorders
- Glycosylation and Glycoproteins Research
- Phagocytosis and Immune Regulation
- Eosinophilic Disorders and Syndromes
- Marine and coastal plant biology
- Protein Degradation and Inhibitors
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Genomics, phytochemicals, and oxidative stress
- Blood disorders and treatments
- Sinusitis and nasal conditions
University of Bonn
2017-2022
Institute of Molecular Medicine
2022
University Hospital Bonn
2020
RELX Group (United States)
2018-2019
Justus-Liebig-Universität Gießen
1996-2008
University Hospital Schleswig-Holstein
2007
University of Lübeck
2007
Friedrich-Alexander-Universität Erlangen-Nürnberg
2006
Universitätsklinikum Gießen und Marburg
1999-2005
Zentrum für Kinderheilkunde
2004
Dendritic cells (DCs) are thought to form a dendritic network across barrier surfaces and throughout organs, including the kidney, perform an important sentinel function. However, previous studies of DC function used markers, such as CD11c or CX3CR1, that not unique DCs. Here, we evaluated role DCs in renal inflammation using reporter mouse line two lines with DC-specific reporters,
We have isolated the human GRAF gene (for GTPase regulator associated with focal adhesion kinase pp125 FAK ). This was fused MLL in a unique t(5;11)(q31;q23) that occurred an infant juvenile myelomonocytic leukemia. encodes member of Rho family GTPase-activating protein (GAP) family. On level, it is 90% homologous to recently described chicken functions as GAP RhoA vivo and thus critical component integrin signaling transduction pathway. The particular position at 5q31 proposed...
Abstract The translocation t(9;11)(p22;q23) is a recurring chromosomal abnormality in acute myeloid leukemia (AML) fusing two genes designated as MLL and AF9. Within MLL, almost all rearrangements cluster an 8.3‐kb restricted region fuse 5′ portions of to variety heterologous various 11q23 translocations. AF9 one the most common fusion partners MLL. It spans more than 100 kb, breakpoint regions (BCRs) have been identified telomeric intron 4 (BCR1) within introns 7 8 (BCR2). We investigated...
Autoimmune vasculitis is a group of life-threatening diseases, whose underlying pathogenic mechanisms are incompletely understood, hampering development targeted therapies. Here, we demonstrate that patients suffering from anti-neutrophil cytoplasmic antibodies (ANCA)-associated (AAV) showed increased levels cGAMP and enhanced IFN-I signature. To identify disease potential therapeutic targets, developed mouse model for pulmonary AAV mimics severe in patients. Immunogenic DNA accumulated...
TEL/AML1 gene fusion is the most frequent genetic lesion in pediatric acute lymphoblastic leukemia (ALL). It occurs as a consequence of cryptic chromosomal translocation t(12;21)(p13;q22). In cohort 50 RT-PCR-positive patients, karyotype examination by GTG banding and fluorescence situ hybridization (FISH) allowed us to identify chromosome anomalies addition already existing t(12;21). Secondary aberrations were found 29 out 41 patients (71%) at initial diagnosis all 9 with relapse....
The characteristic chromosomal translocation t(9;22)(q34;q11) in chronic myeloid leukaemia (CML) mainly results the two different BCR/ABL fusion transcripts b2a2 or b3a2. Both transcript variants can occur simultaneously due to alternative splicing of b3a2 transcript. Conflicting have been reported on influence haematological findings at diagnosis and course disease adults while data concerning these topics childhood CML are still missing. This paper reports a correlation with patients'...
The translocation t(8;21)(q22;q22), which results in the fusion of AML1 (RUNX1) and ETO (CBFA2T1) genes, is a recurrent aberration acute myeloid leukemia (AML), preferentially correlated with FAB M2, has highest incidence childhood AML. Because favorable prognosis, evidence t(8;21) or AML1/ETO gene mandatory most therapy trials, allowing stratification patients to correct risk group terms treatment. Here we present six out 59 children AML who were positive for by RT-PCR, but showed no...