A5101720838- Alzheimer's disease research and treatments
- Nerve injury and regeneration
- Neurological Disease Mechanisms and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurogenesis and neuroplasticity mechanisms
- Natural Antidiabetic Agents Studies
- Medicinal Plants and Neuroprotection
- Axon Guidance and Neuronal Signaling
- Supramolecular Self-Assembly in Materials
- Fibroblast Growth Factor Research
- Advanced Glycation End Products research
- RNA modifications and cancer
- Curcumin's Biomedical Applications
- Tryptophan and brain disorders
- Cancer-related molecular mechanisms research
- Mitochondrial Function and Pathology
- Nuclear Receptors and Signaling
- Pharmacological Effects of Natural Compounds
- Ginseng Biological Effects and Applications
- Cholinesterase and Neurodegenerative Diseases
- Protein Tyrosine Phosphatases
- Advancements in Transdermal Drug Delivery
- Chromatin Remodeling and Cancer
- Allelopathy and phytotoxic interactions
- Heavy metals in environment
First Hospital of Jiaxing
2025
Wenzhou Medical University
2025
Jinan University
2012-2024
China Geological Survey
2024
China-Japan Friendship Hospital
2022
Beijing Chaoyang Emergency Medical Center
2022
Shanghai Institute of Nutrition and Health
2021
University of Chinese Academy of Sciences
2021
Shanghai Institutes for Biological Sciences
2021
Jinan University
2021
The PC12 cell line is a classical neuronal model due to its ability acquire the sympathetic neurons features when deal with nerve growth factor (NGF). In present study, authors used variety of different methods induce cells, such as Opti-MEM medium containing concentrations fetal bovine serum (FBS) and horse compared RPMI-1640 medium, then observed neurite length, differentiation, adhesion, proliferation action potential, well protein levels axonal growth-associated 43 (GAP-43) synaptic...
Although lipopolysaccharides (LPS) have been used to induce an Alzheimer’s disease like animal model, the exact mechanisms involved not studied. This study was designed confirm model of learning and memory impairment induced by LPS, explore which biological processes pathways taken part in it. Mice were continuously intraperitoneally injected with LPS for 7 days. Learning related behavioral pathological performances tested Morris water maze immunostaining respectively. The expressions C1q,...
Curcumin (CUR), a nontoxic polyphenol derived from the rhizome of turmeric (Curcuma longa), has been recognized as an anti-cancer and chemo-preventative agent. However, its clinical application for cancer treatment greatly limited due to poor water-solubility low bioavailability. To tackle this problem, Pluronic F68-CUR (F68-CUR) conjugate micelles, which are amphiphilic copolymers, were designed synthesized in study. These highly stable micelles with CUR concentrated core formulated using...
Abstract The identification and quantification of the ecological risks, sources distribution heavy metals in purple soils are essential for regional pollution control management. In this study, geo-accumulation index (I geo ), enrichment factor (EF), (PI), potential risk (RI), principal component analysis (PCA) model geographical detector (GD) were combined to evaluate status, risk, (HMs) from a typical soil areas Sichuan province. results showed that average contents As, Cd, Cr, Cu, Hg, Ni,...
Methyl 3,4-dihydroxybenzoate (MDHB), a kind of phenolic acid compounds, has been reported to have antioxidant effects. Moreover, our previous study found that it could promote neurite outgrowth and brain-derived neurotrophic factor expression in cortical neurons neonatal rats. In the present study, we focused on mechanism its effect; results showed MDHB-induced upregulation neuronal survival cultured primary be blocked by adenosine A2a receptor inhibitor (ZM241385) phosphoinositide 3-kinase...
Neural stem cell (NSC) differentiation and proliferation are important biological processes in the cerebral neural network. However, these two abilities of NSCs limited. Thus, induction and/or through administration plant-derived small-molecule compounds could be used to repair damaged networks. The present study reported that gallic acid (GA), an phenolic found tea, selectively caused differentiate into immature neurons promoted NSC by activating mitogen-activated protein...
Precise building of multifunctional nano/microarchitectures holds exciting prospects in various biomedical applications such as drug delivery, biosensing, and disease diagnosis. However, the reported architectures still face great challenges when implemented vivo due to insufficient biocompatibility, inevitable invasiveness, low stability, difficulty for reconfiguration. Here, we report an optically reconfigurable platelet architecture through organic integration programmable optical...
Ferulic acid (FA) is a natural compound that expresses antioxidant and anti-inflammatory activities. Microglial cells are innate immune reside within the central nervous system (CNS). Activated microglia mediated neuronal immunity contributes to neurodegeneration associated with Alzheimer's disease. In this study, we investigated inhibitory effect of FA on neuroinflammation in BV-2 microglial induced by lipopolysaccharides (LPS). Our study showed significantly suppressed production nitric...
Disabilities triggered by neurodegeneration mainly result in mortality the elderly, and patients with neurodegenerative disease also display deficits olfactory function. Therefore drug distribution to brain through intranasal administration has become one of most difficult challenges treatment central nervous system (CNS) diseases. TAT-human acidic fibroblast growth factor (HaFGF) is a new fused protein retaining neuroprotective activities HaFGF, promising prospect TAT (a cell-penetrating...
In this study, we evaluated the neurotrophic effects of magnesium fructose 1, 6-diphosphate (FDP-Mg) on cortical neurons. The results demonstrated that FDP-Mg promoted dendrite outgrowth and neuronal survival in a dose-dependent manner. order to investigate associated mechanisms, determined adenosine triphosphate (ATP) levels brain-derived factor (BDNF) mRNA expression Treatment with significantly increased ATP BDNF These data suggest can exert increases cellular are involved produced by FDP-Mg.
Neurotoxic amyloid-β (Aβ) peptide causing cognitive function disabilities is one of the most characteristic pathological features in Alzheimer's disease (AD). A novel fusion protein, TAT-haFGF, was administrated to AβPP/PS1 transgenic mice by intravenous (IV) injection and intranasal (IN) delivery, respectively, for 5 weeks compare pharmacodynamics between two routes administration. Our results showed that IN administration TAT-haFGF improved cognition reduced Aβ plaques more significantly...
Hepatocellular carcinoma (HCC) is an aggressive malignancy and the second leading cause of cancer death worldwide. Most current therapeutic agents lack tumor-targeting efficiency result in a nonselective biodistribution body. In our previous study, we identified peptide Ala-Pro-Asp-Thr-Lys-Thr-Gln (APDTKTQ) that can selectively bind to receptor advanced glycation end-products (RAGE), immunoglobulin superfamily cell surface molecule overexpressed during HCC malignant progression. Here, report...