A5087389065- Respiratory viral infections research
- Immune Cell Function and Interaction
- Respiratory Support and Mechanisms
- CAR-T cell therapy research
- Neonatal Respiratory Health Research
- Influenza Virus Research Studies
- Cytomegalovirus and herpesvirus research
- HIV/AIDS Research and Interventions
- Biotin and Related Studies
- Silicon Carbide Semiconductor Technologies
- Reproductive System and Pregnancy
- Sperm and Testicular Function
- Reproductive tract infections research
- Viral Infectious Diseases and Gene Expression in Insects
- HIV Research and Treatment
RMIT University
2022-2024
The Royal Melbourne Hospital
2022
The University of Melbourne
2022
John Wiley & Sons (United States)
2022
Queensland University of Technology
2020
Human immunodeficiency virus (HIV) persistence in blood and tissue reservoirs, including the brain, is a major barrier to HIV cure possible cause of comorbid disease. However, size replication competent nature central nervous system (CNS) reservoir unclear. Here, we used intact proviral DNA assay (IPDA) provide first quantitative assessment defective brain people with (PWH).Total, intact, proviruses were measured autopsy frontal lobe from viremic (n = 18) or virologically suppressed 12) PWH....
Respiratory syncytial virus (RSV) commonly infects the upper respiratory tract (URT) of humans, manifesting with mild cold or flu-like symptoms. However, in infants and elderly, severe disease lower (LRT) often occurs can develop into chronic airway disease. A better understanding how an acute RSV infection transitions to a LRT inflammatory is critically important improve patient care long-term health outcomes. To model phases disease, we infected wild-type C57BL/6 toll-like receptor 7...
Abstract With approximately 131 million new genital tract infections occurring each year, Chlamydia is the most common sexually transmitted bacterial pathogen worldwide. Male and female occur at similar rates both cause serious pathological sequelae. Despite this, impact of chlamydial infection on male fertility has long been debated, effects paternal offspring development are unknown. Using a mouse chronic model, we show that persists in testes, adversely affecting testicular environment....
Severe lower respiratory tract disease following influenza A virus (IAV) infection is characterized by excessive inflammation and lung tissue damage, this can impair function. The effect of toll-like receptor 7 (TLR7), which detects viral RNA to initiate antiviral proinflammatory responses IAV, on function during peak in the resolution phase not fully understood. Using wild-type (WT) C57BL/6 TLR7 knockout (TLR7 KO) mice, we found that IAV induced airway dysfunction both genotypes, although...
Abstract Objectives In clinical chimeric antigen receptor (CAR) T cell therapy, one of the strongest correlates favorable patient responses is lower levels differentiation in cells from peripheral blood mononuclear (PBMC) starting material or CAR product. older patients are inherently more differentiated, but we hypothesised that specific activation protocols could be used to limit during manufacturing, particularly patients. Methods We PBMCs young (20–30 years old) and (60+ healthy donors...