Epidemiological and experimental evidence suggests that high levels of vitamin D, a potent immunomodulator, may decrease the risk multiple sclerosis. There are no prospective studies addressing this hypothesis.To examine whether 25-hydroxyvitamin D associated with sclerosis.Prospective, nested case-control study among more than 7 million US military personnel who have serum samples stored in Department Defense Serum Repository. Multiple sclerosis cases were identified through Army Navy...

Infection with Epstein-Barr virus (EBV) has been associated an increased risk of multiple sclerosis (MS), but the temporal relationship remains unclear.

Abstract A case‐control stud/involving interviews with 672 female lung cancer patients and 735 population‐based controls was conducted to investigate the high rates of cancer, notably adenocarcinoma, among women in Shanghai. Cigarette smok‐ ing a strong risk factor, but accounted for only about one‐ fourth all newly diagnosed cases cancer. Most patients, particularly were life‐long non‐smokers. The risks higher reporting tuberculosis other pre‐existing diseases. Hormonal factors suggested by...

Abstract To determine whether multiple sclerosis (MS) risk increases following primary infection with the Epstein‐Barr virus (EBV), we conducted a nested case‐control study including 305 individuals who developed MS and 610 matched controls selected among >8 million active‐duty military personnel whose serum has been stored in Department of Defense Serum Repository. Time EBV was determined by measuring antibody titers serial samples collected before onset cases, on dates controls. Ten...

Infection with Epstein-Barr virus (EBV) has been associated an increased risk of multiple sclerosis (MS), but the temporal relationship remains unclear.

To determine whether serum levels of 25-hydroxyvitamin D (25(OH)D) in young adults are associated with risk type 1 diabetes mellitus (T1D), we conducted a prospective, nested case-control study among US active-duty military personnel the Department Defense Serum Repository, identifying 310 T1D cases diagnosed between 1997 and 2009 at least 2 samples collected before disease onset 613 controls matched to on age, sex, race/ethnicity, branch service, dates collection. Conditional logistic...

It remains uncertain whether the presence of serum anti-myelin oligodendrocyte glycoprotein (MOG) antibodies in healthy individuals contributes to predict their risk developing multiple sclerosis (MS).Prospective, nested case-control study more than 7 million US military personnel who have samples stored Department Defense Serum Repository. A total 126 MS cases and 252 controls matched by age, sex, race/ethnicity, dates blood collection were included analysis. An ELISA was used detect IgM...

The relation between occupation and bladder cancer in women was examined based on data collected during the National Bladder Cancer Study, a population-based, case-control study conducted 10 areas of United States. Occupational hazards among have received little attention previous studies, part because most studies included too few females to accurately estimate risks. In this large study, 652 white female patients 1,266 controls were interviewed obtain lifetime occupational histories....

Occupation was evaluated as a potential risk factor for lung cancer part of large population based case-control study conducted in the ten urban districts Shanghai. A total 733 newly diagnosed cases male and 760 controls selected from general interviewed to obtain lifetime occupational histories information on smoking other factors. Of approximately 25 major industrial titles examined, significantly raised risks, adjusted smoking, were found employment agricultural production (odds ratio...

There is a paucity of human data on exposure to blast traumatic brain injury (bTBI) and the corresponding systemic cytokine immune response at later time points (i.e., months, years) post-injury.We conducted repeated measures, case-control study, examining associations serum levels pro- anti-inflammatory cytokines, measured both pre- post-deployment with having mild moderate/severe bTBI. Utilizing from Department Defense Serum Repository cytokines were via an ELISA-based array for 15...

Objective: From 2001 to 2006, the Army deployed over 717,000 personnel Iraq and Afghanistan, with 15,000 troops wounded. Little is known about impact of military demographic factors, particularly deployment, occupation, pre-existing medical status, on disability retirement. Methods: A nested case–control study first time, active duty entering from 1997 2004. Cases, individuals granted a retirement were identified by Physical Disability Agency. Five controls matched year entrance each case....

Tumor cells in classic Hodgkin lymphoma produce high quantities of the thymus- and activation-related chemokine (TARC). We measured TARC levels prediagnostic serum samples found strikingly increased values vast majority patients, as early 6 years before diagnosis.

Abstract Background: We investigated whether an immune system environment characterized by elevated serum levels of B-cell activation molecules was associated with the subsequent development classical Hodgkin lymphoma (cHL). Methods: measured B-cell–stimulatory cytokines, IL6 and IL10, soluble CD30 (sCD30), total IgE prior to cHL diagnosis in 103 cases 206 matched controls archived specimens DoD Serum Repository. Results: Prediagnosis sCD30 had strong positive associations risk a 0 1 year...

Chlamydia pneumoniae (Cpn) has been proposed as a possible etiologic agent in multiple sclerosis (MS). However, previous studies were cross-sectional and could not assess whether Cpn infection preceded the onset of MS.The authors conducted prospective nested case-control study among 3 million US Army personnel 121,466 members Kaiser Permanente Medical Care Program (KPMCP) cohort. Serum samples collected prior to MS symptoms available for 83 cases 46 KPMCP Two controls matched each case on...

To evaluate the hypothesis of increased kidney cancer risk after exposure to hydrocarbons, especially those present in gasoline, we conducted a case-control study cohort approximately 100,000 male refinery workers from five petroleum companies. A review 18,323 death certificates identified 102 cases, each whom four controls were matched by location and decade birth. Work histories, containing an average 15.7 job assignments per subject, found for 98% cases 94% controls. job, industrial...

Abstract Lifetime patterns of smoking and occupation based on personal interviews were examined among 3,627 white men 1,200 women who randomly selected from ten areas in the United States during period 1977–1978. These individuals participated control series National Bladder Cancer Study. We estimated, Axelson's method, extent to which habits for given occupational groups would confound estimated relative risk lung cancer 62 occupations 18 women. Among men, confounding by resulted a 30% or...

In Brief Background: While population-based seroprevalence studies of herpes simplex virus type 1 (HSV-1) and 2 (HSV-2) are widespread, seroincidence largely limited to select or high-risk populations. The US military offers a potential population derive national rate estimates for young adults (ages 18–29). Methods: We used banked, longitudinal serum specimens collected in cohort 1094 personnel aged 18 30 years who served between 1989 2005 estimate HSV-1 HSV-2 the young, adult population,...

Journal Article SELECTED EPIDEMIOLOGIC OBSERVATIONS OF CELL-SPECIFIC LEUKEMIA MORTALITY IN THE UNITED STATES, 1969–1977 Get access STEVE SELVIN, SELVIN 1Department of Biomedical and Environmental Health Sciences, University CaliforniaBerkeley, CA 94720. (Reprint requests to Dr. Selvin) Search for other works by this author on: Oxford Academic PubMed Google Scholar LYNN I. LEVIN, LEVIN DEANE W. MERRILL, MERRILL 2Lawrence Berkeley LaboratoryBerkeley, CA. WARREN WINKELSTEIN, JR. American...

OBJECTIVES. This study sought to examine risk factors associated with human immunodeficiency virus type 1 (HIV-1) seroconversion among active-duty men in the US Army. METHODS. One hundred twenty-eight documented HIV-1 between 1988 and 1991 were matched control subjects on demographic variables. Risk factor information was collected for period. RESULTS. Forty-nine case no reported same-gender sex; this includes 34 who also sex women. Seventy 118 other than heterosexual intercourse. Among...

Mycoplasma fermentans is suspected in the development of ‘Gulf War illness’ veterans Operation Desert Storm. We conducted a matched case-control study for prevalence M. -specific antibodies before and after operation, as well seroconversion rates with without complaints illness’. Cases consisted Gulf veterans, who complained various illnesses were enrolled second phase health evaluation by Army Comprehensive Clinical Examination Program (CCEP). Controls selected from did not participate...