A5089468485- Pancreatic and Hepatic Oncology Research
- Hepatocellular Carcinoma Treatment and Prognosis
- Virus-based gene therapy research
- Cancer Research and Treatments
- CAR-T cell therapy research
- Gallbladder and Bile Duct Disorders
- Renal cell carcinoma treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Colorectal Cancer Surgical Treatments
- Liver Disease and Transplantation
- Intestinal Malrotation and Obstruction Disorders
- Surgical Simulation and Training
- Pediatric Hepatobiliary Diseases and Treatments
- Organ Transplantation Techniques and Outcomes
- Immunotherapy and Immune Responses
- Abdominal vascular conditions and treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Neuroendocrine Tumor Research Advances
- Histiocytic Disorders and Treatments
- Gastrointestinal Tumor Research and Treatment
- Neonatal and Maternal Infections
- Oral and Maxillofacial Pathology
- Enhanced Recovery After Surgery
- Minimally Invasive Surgical Techniques
- Antimicrobial Peptides and Activities
Okayama University
2005-2025
Although the current trend in pancreatoduodenectomy (PD) has shifted from open surgery to minimally invasive (MIS), evidence on role of MIS as an element Enhanced Recovery After Surgery (ERAS) PD is limited. This study aimed investigate effect robotic using ERAS protocol outcomes patients undergoing PD. retrospective included 252 who underwent (OPD) or (RPD) managed between January 2017 and March 2023. Outcomes stratified by surgical approach were compared. Multivariable analyses performed...
Cherubism is caused by mutations in SH3BP2. Studies of cherubism mice showed that tumor necrosis factor α (TNF-α)-dependent autoinflammation a major cause the disorder but failed to explain why human lesions are restricted jaws and regress after puberty. We demonstrate inflammation MYD88 dependent rescued absence TLR2 TLR4. However, germ-free also develop inflammation. Mutant macrophages hyperresponsive PAMPs (pathogen-associated molecular patterns) DAMPs (damage-associated activate...
Background: The safety and feasibility of robotic pancreatoduodenectomy (RPD) in high-risk patients with postoperative pancreatic fistula (POPF) have rarely been investigated, although the rate POPF is lower than open (OPD). This study aimed to examine impact surgery on after (PD). Methods: retrospective analysis included 204 who underwent RPD between January 2018 June 2023. Of patients, 126 were included. outcomes OPD compared. Multivariate analyses conducted identify risk factors...
Difficulty scoring systems (DSS) have been developed to quantify the surgical complexity of laparoscopic distal pancreatectomy (LDP). However, few studies validated these in context robotic (RDP). Moreover, impact body composition on RDP outcomes remains unexplored. This study aimed investigate risk factors difficulty RDP, including composition. retrospective included 72 consecutive patients who underwent at our institution between April 2021 and October 2024. Using a modified DSS for LDP,...
Internationally, evidence supporting robotic liver resection (RLR) has gradually increased in recent years. However, a standardized protocol for RLR remains lacking. This study describes surgical and the initial outcomes of high-volume center hepatopancreatobiliary surgery Japan. Patients were placed reverse Trendelenburg position, with supine position anterolateral tumors left lateral posterosuperior tumors. Our standard involved two-surgeon technique. Liver parenchymal transection was...
ABSTRACT Pancreatic metastasis of myxoid liposarcoma (MLS) after primary resection is extremely rare. Herein, we present a case metachronous pancreatic MLS that was successfully treated with robotic spleen‐preserving distal pancreatectomy (SPDP) using the Warshaw technique. A 60‐year‐old woman underwent radical 25‐cm in right thigh receiving neoadjuvant radiotherapy. The patient developed 6‐cm solitary 2 years later. Because no other distant metastases were detected, SPDP (Warshaw technique)...
Abstract Background: Dendritic cell (DC) vaccine therapy represents a promising immunotherapeutic approach by inducing tumor antigen (TA)-specific immune responses. The suppressor gene p53 is one of the most frequently mutated genes, and mutant or wild-type epitopes function as TAs. Previous studies have demonstrated that DCs transduced with non-replicative adenovirus expressing (Ad-p53) (Ad-p53-DCs) induces p53-specific cytotoxic T lymphocytes (CTLs), leading to antitumor immunity. We...
Abstract Background Pancreatectomies combined with arterial resection can be indicated for pancreatic cancer. In a pancreatectomy resection, intraoperative confirmation of blood flow through reconstructed vessels is crucial. This study highlights the usefulness SPY laser fluorescence imaging during pancreatoduodenectomy common hepatic artery (PD-CHAR). Patient and Methods A 55-year-old man borderline resectable head cancer underwent PD-CHAR. After confirming tumor resectability,...
Background: A difficulty scoring system was developed to estimate the surgical outcomes of laparoscopic liver surgery (LLS); however, effect transection area (LTA) on LLS have not been previously examined. Therefore, this study investigated predictive significance LTA for LLS. Methods: This retrospective included 106 patients who underwent in our hospital between January 2012 and December 2023. The association with level operative time investigated. Multivariate analyses were performed...
Abstract Aim Although hepatectomy is a complex surgical procedure, its incidence among older patients has increased due to global aging. However, few studies have focused on the association between age and failure rescue (FTR) posthepatectomy. This study aimed investigate FTR develop risk model for following hepatectomy. Methods We analyzed total of 1371 consecutive who underwent primary July 2003 September 2022. The were divided into three groups according their age: young‐old (<65...
Colorectal cancer (CRC) cells harboring KRAS or BRAF mutations show a more-malignant phenotype than with wild-type and BRAF. KRAS/BRAF–wild-type CRCs are sensitive to epidermal growth factor receptor (EGFR)-targeting agents, whereas KRAS/BRAF–mutant resistant due constitutive activation of the EGFR-downstream KRAS/BRAF signaling pathway. Novel therapeutic strategies treat mutant CRC thus needed. We recently demonstrated that telomerase-specific replication-competent oncolytic adenoviruses...